Many of todays medicines have their origins in nature and today’s post is about medical mushrooms. Mushrooms or fungi have given us a number of treatments and where would people with transplants be without cyclosporin A, which is an immunosuppressive agent derived from fungi.
As any of the long-term readers will know, I introduced the concept of “mushroom food” rather than say this is BS (pooh from a male cow). But today there really is a story of mushroom food and our furry friends.
It rained last week so we should be seeing the first crop of 2022 mushrooms and I will be out an about, but which ones should you pick to get rid of your MS?
Here is what was used in the current study
This paper looks at the effect of these mushrooms in an animal model of demyelination and reports positive effects. Will it be in a news?
Yamashina K, Yamamoto S, Matsumoto M, Iwasa K, Takeda N, Haruta C, Maruyama K, Shimizu K, Yoshikawa K. Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model. Int J Med Mushrooms. 2022;24(9):15-24.
Epidemiologic studies have shown a high prevalence of multiple sclerosis (MS) in Europe and North America, and a low prevalence in East Asia. Mushrooms contain various biological response modifiers (BRMs) and are widely used in traditional Chinese medicine in East Asian countries. To investigate whether mushrooms have potential beneficial effects on MS, we administered mushrooms to cuprizone (bis-cyclohexanone-oxalyldihydrazone, CPZ)-induced MS model mice. This model is used to study the processes of demyelination in the CNS. The CPZ-induced demyelination is involved in the apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. Mice were fed a powdered diet containing 5% each mushroom and CPZ diet for 5 weeks, which coincides with peak demyelination. We measured the body weight of the mice, evaluated their motor function using a rotarod, and quantified the myelin levels using Black-Gold II staining. Ganoderma lucidum and Hericium erinaceus treatments showed recovery from weight loss. Pleurotus eryngii, G. lucidum, and Flammulina velutipes treatments significantly improved CPZ-induced motor dysfunction. P. eryngii, G. lucidum, F. velutipes, and H. erinaceus treatments effectively suppressed CPZ-induced demyelination. The four medicinal mushrooms may be promising BRMs for prevention and alleviation of the symptoms of MS.
I am sure many of you have eaten the occasional king oyster mushroom but did you feel better for it?
I must say this needs would need to be shown to be of value in humans before it could be recommended, so do not go down to the health food shop.
If a mouse eats about 3-5 grammes a day (in about 15-20 meals), which is about a quarter (forth) of its body weight a day. If the mushoom is 5% in the food, it is a 20th of 3-5grammes a day so about 0.25g of mushrooms for a 25g mouse so dose equivalent dose 100th of 70kg (average human) = 0.7kg of mushrooms a day. So for the four mushrooms, it is about 3kg of mushrooms a day for 5 weeks