ArchiveSeptember 2022

Paedeatric MS and DMF.

Young people develop MS and they need treatment options too. This study examines dimethyl fumarate and compared it to beta interferon and guess what? Dimethyl fumarate has a greater efficacy . I hear some of you say “NSS”. I must admit it is rather sad that 72 individuals get put on a treatment that we essentially not as efficacious. Now we have to see that it is safe, but surely we...

Rituxi, ocri, ofatu and now Ubli

Prof Steinman has been heard calling this new agent “Ubli”….but this is yet another CD20 antibody on the way, but perhaps it is a bit surprising. Not surprisingly this inhibts relapsing MS Initially we had rituximab that was part mouse part human and then we got humanized and then a fully human antibody, but ubli is back to part mouse part human, but with augmented cell-mediated...

Sphingosine Kinase and S1P

Many moons ago it was suggested that fingolimod could be used against COVID-19. A trial was planned but it never got off the ground. Fingolimod mimics the action of sphingosine-1-phopsphate (S1P) and similarly needs to be activated before it works. This then downmodulates the S1P receptors and so blocks their function. Fingolimod is activated by sphingosine kinases. There are two of them...

No NDG tuesday…Check point inhibitors for PML

NDG has gone off grid with no computer and so no posts for the next few weeks…..Maybe she would have posted on this paper. The scurge of natalizumab and a few other agents is progressive multifocal encephalopathy caused by infection of the brain with JC virus, meaning that strategies have been developed to limit this potentially fatal disease. This has included switching fromm natalizumab...

#MSCOVID19. Get Boosted if you have had CD20-depleting antibody

I have had my booster. Have you had yours.? This study indicates that if you have had immune-depletion there may be merit in boosters Otto C, Schwarz T, Jeworowski LM, Schmidt ML, Walper F, Pache F, Schindler P, Niederschweiberer M, Krumbholz A, Rose R, Drosten C, Ruprecht K, Corman VM. Humoral immune responses remain quantitatively...

Headaches

Mavridis T, Papagiannakis N, Breza M, Vavougios GD, Patas K, Daponte A, Laskaratos A, Archontakis-Barakakis P, Pantazopoulos I, Mitsikostas DDB-Cell Targeted Therapies in Patients with Multiple Sclerosis and Incidence of Headache: A Systematic Review and Meta-Analysis. .J Pers Med. 2022 Sep 8;12(9):1474. doi: 10.3390/jpm12091474. Background: Multiple Sclerosis treatment with B...

Continuous CD20-depletion or Not

Should anti-CD20 be used as an immune reconstitution therapy? The debate Rolfes L, Meuth SG. Stable multiple sclerosis patients on anti-CD20 therapy should go on extended interval dosing-“YES”. Mult Scler. 2022; 28:691-693 Anti-CD20 antibodies such as rituximab proved powerful yet remained as an off-label treatment in multiple sclerosis (MS) until the approval of ocrelizumab in 2018...

Ofatumumab and COVID

Faissner S, Heitmann N, Plaza-Sirvent C, Trendelenburg P, Ceylan U, Motte J, Bessen C, Urlaub D, Watzl C, Overheu O, Reinacher-Schick A, Hellwig K, Pfaender S, Schmitz I, Gold R. Immune response in ofatumumab treated multiple sclerosis patients after SARS-CoV-2 vaccination. Front Immunol. 2022 Aug 31;13:980526.  Objective: The pandemic induced by SARS-CoV-2 has huge implications for...

Human Zebras and Mice

Zebra fish have stripes and is a model species used to understand biology Zebrafish are a model animal species and are used as they are transparent in early life and there genes can be manipulated to express colours associated with expression of proteins such as the green and red above. You can also make fish that express fluorescent myelin In this study, they remove a fish gene (GPR17) and...

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