Do men with MS deserve to be offered higher efficacy DMTs earlier than women? When you do a baseline prognostic profile of someone with MS, being female is a good prognostic factor compared to being a male. Men have a worse outcome. This study below shows men do worse when it comes to poor cognition compared to women (#ThinkCognition). The question of why women do better cognitively may relate to...
Can studying the pathology of MS and animal models of MS teach us about the cell types driving MS? Professor Lassmann is the doyen of multiple sclerosis pathology. He makes two very important points in this review. EAE the experimental model of MS is not MS. Interestingly, most EAE models are driven by CD4+ T-cells, which is very relevant to the second point he makes. Does this mean we should not...
Can we prevent alemtuzumab-associated listeriosis? The following is a published case report of someone with MS developing listeriosis congruent with their second course of alemtuzumab treatment. It is clear this patient was not taking her diatary advice very seriously. We have a potential solution for this problem. Holmøy et al. Listeria monocytogenes infection associated with alemtuzumab – a...
This the first of our Barts-MS non-personalised, more factual, blog posts. We, Barts-MS, hope you will find this format more agreeable. Happiness is associated with better health outcomes, which may apply to people living with MS and their families. More research needs to be done in this area before any definitive statements can be made in relation to applying happiness therapy as part of the...
This is a summary of my talk at the ACTRIMS 2019 Forum, describing the current state of research using a technique called “metabolomics” in MS patients. The term refers to the measurement of levels of small molecules (for example glucose) in blood or spinal fluid (could be any body fluid). Most metabolomics studies utilize one of two platforms to measure metabolites: nuclear magnetic resonance...
This afternoon Mouse Doctor and Neuro Doc Gnanapavan broadcast live from the MS Paris ECTRIMS ACTRIMS conference for a one hour Google Hangout. This was your opportunity to listen to the summary of what they’ve seen but also respond to questions posted by readers of this blog. You can watch a recorded video of the event here: Image above of the broadcast team, supported by Dr M&M...
Kalincik T, Jokubaitis V, Spelman T, Horakova D, Havrdova E, Trojano M, Lechner-Scott J, Lugaresi A, Prat A, Girard M, Duquette P, Grammond P, Solaro C, Grand’Maison F, Hupperts R, Prevost J, Sola P, Ferraro D, Terzi M, Butler E, Slee M, Kermode A, Fabis-Pedrini M, McCombe P, Barnett M, Shaw C, Hodgkinson S, Butzkueven H; MSBase Study Group. Cladribine versus fingolimod, natalizumab...
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Today is World MS day A message from BartsMS P.S. It’s really only 4 minutes long….Have a look You can view ProfG and DrK through his Rose-tinted Glasses. To get any new initiative off the ground you often need pilot data and this takes resource. We have launched BartsMS Charity as vehicle that may allow that to happen in a more timely manner. It may allow us to tackle...
On Saturday we were at Great Ormond Street to take part in their educational day for families affected by demyelinating conditions. Although the Digesting Science activities were originally designed to teach children aged 6 – 12 about their parents MS, they can also teach children about their own condition. The morning was really inspiring and we met some amazing young people with a good...