AuthorDrRuth

Your chance to influence preventive research!

Avid readers of the blog will have heard us talk about MS prevention, and the new(ish) Preventive Neurology Unit that Prof G has helped to set up to study this. We are really keen that people affected by MS are able to tell us the kind of questions that they would like us to work towards answering. I have been tasked with looking at the causes and  exploring the possibilities for preventing...

Utility of Disease-Specific Measures and Clinical Balance Tests in Prediction of Falls in Persons With Multiple Sclerosis.Dibble LE, Lopez-Lennon C, Lake W, Hoffmeister C, Gappmaier E.J Neurol Phys Ther. 2013 Jul 18. [Epub ahead of print] BACKGROUND AND PURPOSE: The sensory and motor deficits associated with multiple sclerosis (MS) contribute to falls with the majority of persons with MS...

New secondary progressive MS trial is launched

.#MSreserarch Progressive Trial Launched For anyone that hasn’t seen this in the news today, the MS-SMART trial has had its initial press release. This trial, which we are involved in, is being co-ordinated by Dr Jeremy Chataway from UCL. The aim is to compare 3 existing drugs (amiloride, ibudilast and riluzole), which have the potential to be useful in secondary progressive MS. The BBC...

Smoking..Still time to Stop!

What can we do to get MSers to stop smoking? #MSBlog #MSResearch Epub: Manouchehrinia A, Tench CR, Maxted J, Bibani RH, Britton J, Constantinescu CS. Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study. Brain. 2013 Jun 11. Tobacco smoking has been linked to an increased risk of multiple sclerosis. However, to date, results from the few studies on the...

Can we predict disease progression?

Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome. Kalincik T, Guttmann CR, Krasensky J, Vaneckova M, Lelkova P, Tyblova M, Seidl Z, De JagerPL, Havrdova E, Horakova D.Genes Immun. 2013 Apr 11. doi: 10.1038/gene.2013.17. [Epub ahead of print]AbstractIt has not yet been established whether genetic predictors of multiple sclerosis (MS)...

How do we define progression in clinical trials?

Epub: Healy et al. Assessment of definitions of sustained disease progression in relapsing-remitting multiple sclerosis. Mult Scler Int. 2013;2013:189624. doi: 10.1155/2013/189624. Epub 2013 Mar Sustained progression on the expanded disability status scale (EDSS) is a common outcome measure of disease progression in clinical studies of MS. Unfortunately, this outcome may not accurately...

Cognitive slowing and falls

Epub: Sosnoff et al. Cognitive Processing Speed is Related to Fall Frequency in Older Adults with Multiple Sclerosis. Arch Phys Med Rehabil. 2013 Feb 16. doi:pii: S0003-9993(13)00134-2. 10.1016/j.apmr.2013.02.009.  OBJECTIVE: To examine mobility, balance, fall risk and cognition in older adults with multiple sclerosis (MS) as a function of fall frequency...

Should we all be getting more sun?

Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis. Zivadinov R, Treu CN, Weinstock-Guttman B, Turner C, Bergsland N, O’Connor K, Dwyer MG, Carl E, Ramasamy DP, Qu J, Ramanathan M. J Neurol Neurosurg Psychiatry. 2013 Feb 5. [Epub ahead of print] PURPOSE: To assess the relationships of sun exposure history, supplementation and...

Do MSers have an increased risk of heart disease?

Epub: Jadidi E, Mohammadi M, Moradi T. High risk of cardiovascular diseases after diagnosis of multiple sclerosis. Mult Scler. 2013 Jan 30. BACKGROUND: Studies of the risk of cardiovascular diseases (CVDs) in patients with multiple sclerosis (MS) have the potential to improve our understanding of the etiology of and the heterogeneity of prognosis and outcomes. OBJECTIVES: To...

Research: is obesity related to childhood MS?

Langer Gould A, Brara SM, Beaber BE, Koebnick C: (epub) Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome Neurology 2013 OBJECTIVE:To determine whether childhood obesity is a risk factor for developing pediatric multiple sclerosis (MS) or clinically isolated syndrome (CIS). METHODS:Cases were identified through the Kaiser Permanente Southern California...

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