AuthorDr Wafa

50+ shades of grey matter

One of the commonest myths about the brain is that we use only 10% of it. The origin of this probably goes back to the unsung hero of neuroscience, William James, when he was jokingly commenting on the fact that the functioning neurons sum up to only 10% of the brain cells and the 90% are supportive cells. Grey matter looks darker because it contains more dense aggregation of cells The grey...

Brain footprints tell us which way did it go

Sometimes for us to know the future, we need to look back into the past. We can predect how an MS brain will be if we looked back to how it was. Human beings have large heads compared to other animals. This is one of the reasons human babies need to be born well before reaching brain maturity or otherwise they will get stuck and never come out! In anthropology, when you get a skull of a human and...

The 1st anti-plasma cell drug in MS. What should you ask?

SIZOMUS is a short name for “Safety of IxaZOmib targeting plasma cells in MUltiple Sclerosis” I first became the study Clinical Research Fellow on the “SIZOMUS” clinical trail last year. Instantly my brain filled up with questions. I thought I’d go straight to the horse’s mouth for the answers and sought out the two lead study investigators – Prof...

RUN SIZOMUS RUN!

Mama Always Said, Life Was a Box of Chocolates. You Never Know What You’re Gonna Get – Forrest Gump, 1994  A few years back Prof G, whilst talking about MS at a conference was approached by Takeda Pharmaceuticals on whether we would be interested in targeting plasma cells; probably one of the last frontiers in MS. The ideas started spinning from there. Roll forward...

The Plasma cell story – how MS begins and ends

In 1875, a famous German scientist; Wilhelm Gottfried Waldeyer Hertz, described an immune cell with a large cytoplasm (the space within the cell aside from the nucleus), he was the first to name it the “plasma cell”. We now know that this large cytoplasm hosts a production line that is solely dedicated to antibody formation (up to 10,000 molecules per second per cell). They account for less than...

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