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#MSCOVID19. Is an MS treatment of value in getting rid of SARS-CoV-2?

ProfG has suggested that teriflunomide may be anti-viral. So what does it do against COVID-19?.. I don’t know? But studies from arthritis can give us a clue. Why because, when you take leflunomide in arthritis…it breaks down to be teriflunomide. So what happens with leflunomide in COVID-19?. Maybe ProfG is on to something…interesting..it needs a proper study Efficacy and Safety...

#MSCOVID19…What started me off

Some weeks ago I was asked to review this paper and at first I said yes, thinking that it was important to turn papers around quickly, I did the review within a coule of hours and sent it back to the Editor. However, I said I didn’t want to take any further part in the review process. So my review was thrown away and never got sent to the authors…..and they got other reviewers to play...

Q&A June 2020

Want to Ask a Question this is the place for You

Springwatch….There was some strange holes in the grass….so we got a night camera guess what we found?

More evidence that MS-DMT are a damp squibb as far as #MSCOVID19 is concerned

COVID-19 in Multiple Sclerosis Patients and Risk Factors for Severe InfectionChaudhry, F., Bulka, H., Rathnam, A. S., Said, O. M., Lin, J., Lorigan, H., Bernitsas, E., Rube, J., Korzeniewski, S. J., Memon, A. B., Levy, P. D., Javed, A., Lisak, R., Cerghet, M.10.1101/2020.05.27.20114827 — Posted: 2020-05-29 Wow this figure is a bit vivid, but this follows the same pattern we are seeing over...

#MSCOVID19. Trial results of interferon Beta

You can read….best wishes Efficacy and safety of interferon beta-1a in treatment of severe COVID-19: A randomized clinical trialDavoudi-Monfared, E., Rahmani, H., Khalili, H., Hajiabdolbaghi, M., Salehi, M., Abbasian, L., Kazemzadeh, H., Yekaninejad, M. S.10.1101/2020.05.28.20116467 — Posted: 2020-05-30 Objectives: To the best of our knowledge, there is no published study regarding use of...

Why are many people doing OK in the #MSCOVID19 era

To get a vaccine response for COVID-19 we need antibodies but we also need T cells. CD4 T cells help macrophages and B cells and others to do their stuff. CD8 T cells are the main anti-viral cells. So studies in people infected with COVID show a clear anti-COVID response and people treated with novel COVID-19 vaccines show antibody and T cell responses (Zhu et al. Lancet. 2020 May 22:S0140...

Why have MS-DMT not impacted on #MSCOVID19 and vice versa…Simples it may not be an immune issue

Since the COVID-19 story broke we have been focusing on the immune system, because after all the immune system will ultimately get rid of the virus. We have made the point that many MS-DMT may not grossly inhibit the cells responsible for the anti-viral response and so MS-DMT may not stop you responding sufficiently to the SARS-CoV-2 virus. More recently we have been suggesting that a central...

Get you Nice Shiney (Butchered) #MSCOVID19 Review Here

The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.David Baker, Sandra Amor, Angray S. Kang, Klaus Schmierer, Gavin GiovannoniMult Scler Relat Disord. 2020 May 12 : 102174. doi: 10.1016/j.msard.2020.102174 [Epub ahead of print]. This review has been type set and still not on pubmed. Here is the...

Has NDG cured PML?

So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML. If you can remember from yesterday immune check point inhibitors. One...

COVID Breafast. What’s has space travel, COVID19 and the Science self-publicity machine got in common to help MS?….Maybe Too Late! has NDG cured PML?

The Space programme gave us a man on the moon , but in the process of that a lot of innovation was developed…like the Space Pen that I carry that writes upside down and underwater. Others include Artificial limbs. …Insulin pump. …DustBusters. …Shock absorbers for buildings. …Solar cells……Cold-Weather Wearables. …Foil Blankets. …Scratch...

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