AuthorMouseDoctor

Let it Glow. UK Vaccination responses with AZ and Pfizer.

Today the COVID-19 story surfaces and DrRuth (BartsMS) and Emma T (Cardiff) share the limelight for what havs been a joint effort The rest are alphabetical and DrAngray should have been called Wang not Kang as he would be near the end. This is the result of UK collaboration and looks at the vaccination response. I won’t post on the content yet but let Dr. Ruth or others do this but it shows...

Q&A August

This month it is the Summer Olympics so today we have Discus fish

Sculpture from the East End of London

Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.

Good news for fingolimod vaccine failures perhaps?

The problem child for covid-19 vaccine responses is fingolimod maybe the solution is to have another vaccine dose with RNA vaccine as people with transplante responded after three vaccine cycle Comparison of infected and vaccinated transplant recipients highlights the role of Tfh and neutralizing IgG in COVID-19 protectionCharmetant, X., ESPI, M., Benotmane, I., Heibel, F., Buron, F., Gautier...

The writing was on the wall for fingolimod…But it was written in invisible ink:-( The destiny of vaccination responses.

When I was an scientific amoeba  beta interferon came along and worked in MS then we had a sea of papers in EAE telling us that beta interferon was immunomodulatory in mice. I thought who cares at that point as you know the answer in humans, why waste animals? Also you could see it was rather rubbish in animals except in the study that used human beta interferons in mice….They should have...

#MSCOVID19

COVID-19 vaccines and multiple sclerosis disease-modifying therapies Gavin Giovannoni,Christopher H. Hawkes,Jeannette Lechner-Scott,Michael Levy,E. Ann Yeh,David Baker MSARDS DOI: Much more evidence has emerged since our first editorial in April 2020 on the use of multiple sclerosis (MS) disease-modifying therapies (DMTs) during the pandemic (Giovannoni et al., 2020) and a further publication in...

Splosh, Splosh Splosh, the drips are increasing Vaccination and fingolimod and anti CD20 are like oil and water…Not mixing

Today we have the first interim analysis of vaccination data from Italy they have looked at over 700 people on their way to studying 2000 people. So I think we can safely say in terms of anti-CD20 and fingolimod, that they are problem children in terms of the antibody response Effect of SARS-CoV-2 mRNA Vaccination in MS Patients Treated With Disease Modifying Therapies. Sormani et al. Background:...

Having Two Pricks. You are not alone!

No nothing to do with Lizards:-) but the Jabs…..Well done MS-Britain you want the Jab…but let’s finish the job/jab Highlights •94.4% of people with multiple sclerosis (MS) would accept a COVID-19 vaccine•People of increasing age and influenza vaccinations were more likely to accept•Safety concerns and lack of information were top reasons for not getting a vaccine•51.7% of people...

COVID19..Drip, Drip Drip….B cell repopulation determines the ability to give antibody response after COVID-19 vaccination

Learning from other conditions is useful. As there are more people with rheumatoid arthritis than MS we will see alot of anti-CD20 papers with rituximab. There will be subtle differences compared to ocrelizumab. So when you read the paper that says the vaccine response to anti-CD20 is unknown….it’s not its getting less unknown by the day. If you are taking ocrelizumab you should...

Off-Label Use of Drugs

I give you something that is not MS COVID (p.s. thats below). Laurson-Doube J, Rijke N, Helme A, Baneke P, Banwell B, Viswanathan S, Hemmer B, Yamout B. Ethical use of off-label disease-modifying therapies for multiple sclerosis. Mult Scler. 2021 Jul 26:13524585211030207. doi: 10.1177/13524585211030207. Epub ahead of print. PMID: 34304636 Background: Off-label disease-modifying therapies...

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