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How Do you Want Your Information?

Hopefully you consider the Blog as a source of information, but how do you want that information delivered? Do you want it in a Faberge Egg or a paper bag? The paper bag costs $10 and the egg costs $5,000. Sure I know if it was a real Faberge egg it would be more, and $10 for a paper bag, you say I’m having a laugh, but the question I pose is a real question. I do work and I report it...

Interogating MS with new technology, it’s a T & B cell co-operation thang.

With new technology is was not a question of if, but a question of when the protein production array of individual cells will be done, You can now look for the antigen-specific receptors of each cell to find out what they target is you can look at the proteins they make to say what cell types are there and this latter aspect was the focus of this study. They got the protein signatures...

Newsflash: Avoid the Links from TRIMS.Online today

When is an International MS meeting a Shop front for Replacement Windows?

When it’s TRIMS.ONLINE

Don’t click on the links that are active if you view with a phone

You won’t get information for the meeting

Stay away from the trims.online links (above in italics) on your phone

Dear Oh Dear

Siponimod controls progressive MS by enhancing regulatory cells….It’s behind you!

As we are in pantomine season when the baddy (ghost) is behind you about to pounch, and when you ask I wonder where the baddy is? The audience shouts out “he’s behind you” and you don’t turn your head, you slowly turn your body as the baddy turns to stay behind your back, so when you turn round, there is nothing there. So you say “Oh no he isn’t” and the...

Anti-TNF therapy says MS is one disease

Since their introduction in 1999, anti-tumour necrosis factor-α (anti-TNF-α) therapies have been suspected repeatedly to be associated with the occurrence of central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS). However, recent publications were restricted to descriptions of monophasic demyelinating events or cases of relapsing-remitting MS (RRMS). We here...

Cellular targets

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P. Science. 2019; 366(6472). pii: eaax9198. doi: 10...

Brain Demyelination Ribbons..Unique to MS

Extensive subpial cortical demyelination is specific to multiple sclerosis. Junker A, Wozniak J, Voigt D, Scheidt U, Antel J, Wegner C, Brück W, Stadelmann C. Brain Pathol. 2020. doi: 10.1111/bpa.12813. [Epub ahead of print] Cortical demyelinated lesions are frequent and widespread in chronic multiple sclerosis (MS) patients, and may contribute to disease progression. Inflammation and...

B cell depleting Milk

Pregnacy is an important issue. At present few MS treatments are available for use in pregnacy. If you are taking ocrelizumab you have to wait for 6 months in the USA and 12months in the EU before you try to concieve. Why?. This is because the antibody hangs around for a long time. An So if you get an infusion of 600mg of ocrelizumab, which equates to about 600mg in 5 litres of blood so...

Risk factors for reactivation of clinical disease activity in multiple sclerosis after stopping natalizumab

You can all read the text, natalizumab seems to hold everything in check Risk factors for reactivation of clinical disease activity in multiple sclerosis after natalizumab cessation. Mustonen T BM, Rauma I MD, Hartikainen P MD, PhD, Krüger J MD, PhD, Niiranen M MD, Selander T M.Sc, Simula S MD, PhD, Anne M R MD, PhD, Kuusisto H MD, PhD. Mult Scler Relat Disord. 2019 Nov 5;38:101498...

Another mechanism of damage involving microglia

If a nerve cannot talk to another nerve, problems may occur. Loss of myelin will slow nerve transmission but if there is no synapse (the point where one nerve contacts another nerve) there is no nerve signal transmission. In this study they look at the visual system and they find that synapses are lost, even if there is seemingly no demyelination, They showed that microglia are removing the...

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