AuthorMouseDoctor

ACTRIMS 2021 Guess what ocrelizumab depletes memory B cells and in doing so gets rid of EBV infected cells

This is a bit of a No-S-Sherlock moment. If you take anti-CD20 antibodies it depleted peripheral blood B cells out of sight. So in this study they look at the CD19 B cell subsets and conclude it depletes naive and memory B cells which express CD20. There is no suggestion that it may work because of this, but if there is no body because it has been blasted with a shot-gun you would not expect to...

BartsMS to the Excel for the Jab Please read

Heads up! To all with MS, on immunotherapies, heading to the Excel Centre in London for your 2nd jab… As soon as you arrive tell a staff member so you will get taken to the front of the line… and not have to wait for ages (like yours truly). It’s very busy there…

Thanks for the Info and advice from Rachel Horne

ACTRIMS2021. Vaccination responses after cladribine

This week is ACTRIMS2021 week and I could wait until the end of the week to give you the news but public domain, is public domain and for some people a few days will be of value, especially if you have been taking oral cladribine and you are being offered a COVID-19 vaccine, this may help you sleep abit easier. The manufacturers of CLAD “let the baton slip” in 2010/2011 when...

Has pharma made a mistake with BTK inhibitors? Are microglia the good guys that shouldn’t be inhibited? Don’t worry. It’s all about Balance.

I’m a fan of “you can’t have it both ways” and it means that if you say this is good for that you can’t say the opposite is good for that too. So if you have a good guy you want to augment it for it to be good, but if you get rid of the good guy you would think it is going to be be bad. When you are a mechanistic science you sometimes don’t think about the...

Whilst CD20 antibody will probably blunt your anti-COVID19 antibody response. Probably fear not as remember T cells are the important ones. #MSCOVID19

In a rush go to the bottom to read T cells are the important ones. What? Am I having a bit of psychosis? I have been on a B cell crusade and have been saying that B cells are important for MS. ut now its T cells are important. Well yes and Yes. Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K...

Rebound after treatment withdrawal says the important cells for relapse are…yep you got it!

ProfG always said the rebound that occurs after natalizumab was going to be one of the best ways to work out what are the important disease drivers in MS. Natalizumab is a brake for pathogenic cells entering the brain, Remove the brake and cells go in and trigger disease activation. Sadly by the time of thinking about this, strategies to stop rebound were developed and as we would switch...

HSCT vs. Alemtuzumab

So this is not a head to head efficacy study but says what we know alemtuzumab is associated with thyroid disease, HSCT is associated with more infections Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Non-induction Therapies for Multiple SclerosisPeter Alping, Joachim Burman, Jan Lycke, Thomas Frisell, Fredrik PiehlNeurology Jan 2021, 10.1212/WNL...

COVID 19 in Scotland

Our friends from Scotland have reported on the the occurance of Scottish COVID-19 in people in the MS register. You don’t need me to explain this as it is clear in its message but have a read of the paper as you can read the reports of the three referees report on the merits of the post. Fernandes PM, O’Neill M, Kearns PKA, Pizzo S, Watters C, Baird S, MacDougall NJJ, Hunt DPJ. Impact...

Is there a #MSCOVID-19 Surge? How about the Zombie apocalypse? What about pregnancy?

You never know what the media may pick up and this is one that the “doom and gloomer”s may like. The authors suggest that as it has been suggested that MS may be caused by virus Therefore SARS-CoV-2 may cause a surge in MS and as JC virus in the brain is a problem with natalizumab, because SARS-CoV2 causes neurological problems, then you have to be concerned. Although never say...

Meta Analysis #MSCOVID19

Sharifian-Dorche M, Sahraian MA, Fadda G, Osherov M, Sharifian-Dorche A, Karaminia M, Saveriano AW, La Piana R, Antel JP, Giacomini PS. COVID-19 and disease-modifying therapies in patients with demyelinating diseases of the central nervous system: A systematic review. Mult Scler Relat Disord. 2021 Jan 29;50:102800 If you want to see a more recent review of the influence of COVID-19 you can see...

Translate

Categories

Recent Posts

Recent Comments

Archives