AuthorMouseDoctor

Tea Time, HSCT inhibits brain infiltrating T cells

Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis. Harris KM, Lim N, Lindau P, Robins H, Griffith LM, Nash RA, Turka LA, Muraro PA. JCI Insight. 2020;5(2). pii: 127655. A recent study of autologous hematopoietic stem cell transplantation (AHSCT) for active relapsing-remitting multiple sclerosis (RRMS) showed efficacy in preventing disease...

DrAngry makes QM (Students) Happy

Irony of Humanization part VI and a half DrAngry not only gave you a valentine present last week, that as MD2 says “Is better than chocolate and flowers” but in the process also gave Queen Mary students a big smile, as they saw their hard effort become a paper and a new tool to help neuros give better treatment to you. Last week we saw the first publication of a new technology to...

I’m a vegan can I have antibody treatment?

This is up to you. it’s your choice. The important question is how do you make an antibody? I have to say all of them have their historical and technological origins in a furry beasty, notable mice and rats. You said “ I read that ocrelizumab was made from Chinese hamster ovary cells…. Is my ocrelizumab harvested inside a hamster?” Is the Hamster straining to push-out...

Science Fiction: Vitamin D

Failed vitamin D trial..Failed to infrom:-( ProfG has done a post on medical fiction. It is perhaps approriate to do a post on science fiction. As you know scientists are like sheep and they herd together and follow one and other. They stick close to the “dogma machine” and follow trends because, this is where money gets put. I have gone on the record of discussing a few. Some I have...

Astrocyte targets

The expression of MAFG in mice is high compared to human (Data from public data bases MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ.Nature. 2020 Feb 12...

Alemtuzumab.The irony of Humanisation. Part V

What have we been doing. So over the past week has been building up the story of alemtuzumab, the Worlds first Humanized antibody. However, it is the worst when it comes to anti-drug antibody responses. The paper today argues perhaps why. So if you are taking alemtuzumab it is a must-read. So you can sit down in you arm chair and have a good read. The paper is now online so click here , download...

shoes for foot drop

Pilot Study of Cadence, a Novel Shoe for Patients with Foot Drop.Evora A, Sloan E, Castellino S, Hawkes EW, Susko T. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:5291-5296 Foot Drop is a mobility disorder that limits ankle dorsiflexion, complicating the swing phase of gait and balance. It is a common result of a neurological injury or disease such as stroke, cerebral palsy or multiple sclerosis...

Why is DrAngry angry? Cos some people are getting futile antibody treatments. Today it’s Rituxumab and futile is not the only issue..Danger is another!

I know that you hate mysteries and some people have been asking “Who is DrAngry?”. In short our antibody guru and go to guy for technological ideas. To help you guess, here is a clue from Basil Brush. Never seen Basil? Click here. Helps if you are over 45 Boom Boom Antibodies can stop working because they cause anti-drug antibody (ADA) responses. Alemtuzumab is particularly adept at...

Lovey moment. The Science microcosm

Don’t you just love it when you hear critics arguing over the meaning of a painting. Does this picture say something about the state of science. Two little mice (Basic scientists) fighting over scraps (cash) when the mouse food (grants) store is elsewhere in another station. A fight over this cell or that cell (idea) in the hope they win and eat. Will it then give them the right microbiome...

Inflammation in CNS is associated with activity

Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS. Engel S, Friedrich M, Muthuraman M, Steffen F, Poplawski A, Groppa S, Bittner S, Zipp F, Luessi F. Neurol Neuroimmunol Neuroinflamm. 2019;6(5). OBJECTIVE: We explored the incremental value of adding multiple disease activity biomarkers in CSF and serum for distinguishing MRI-based benign...

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