AuthorMouseDoctor

A week too late to be the first, but more info on metformin and the remyelination story

Last week we had the suggestion that metforin can act as an anti-aging agent to make oligogendrocyte precursor cells to promote remyelination. This wasn’t the first time it had been suggested and it clearly was not the last. So this new study claims to be the first study to show metformin-induced AMPK ,could potentially accelerate regeneration . What a difference a week makes, becuase first...

Can you change your lifestyle?

I don’t know much about diet and multiple sclerosis, so we got ProfB to blag his way into the Houses of Parliment for a multiple sclerosis meeting on lifestyle and diet Chatting to the stars of the film can you guess who. It was the last time you will see that shirt The building reeks of history and it was pleasure to attend says ProfB. It was rather funny watching the Extinction Rebellion...

Inhibition of B cell survival factors does not inhibit MS

You know me, I love to write papers, pharma seem to hate it, so I say to them just give me the data and save yourself a few grand paying medical writers. OK, they can’t dictatate what I am going to write, but the data generally speaks for itself. They just don’t want to let the data out:-(. After the excitement of HSCT- thursday…. and friday, its back to reality. This post...

Are B cells important?

This week we have had people telling us that T cells are changed in early MS (Click here) and that there were no changes in the B cells. Now we have a suggestion that B cells were active in early MS. I got excited when I saw the title about B cells in early MS. However, then I see the data, this is when I think the figures do not fit the descriptions. They fail the smack you in the eye test (The...

Guidelines for Managing Thyroid dysfunction

This post is for any health-professions who read the blog. This gives guidelines for managing thyroid problems notably after alemtuzumab 2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy. Muller I, Moran C, Lecumberri B, Decallonne B, Robertson N, Jones J, Dayan CM. Eur Thyroid J. 2019 Jul;8(4):173-185. Thyroid...

The microbiome gets stronger

Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis. Duc D, Vigne S, Bernier-Latmani J, Yersin Y, Ruiz F, Gaïa N, Leo S, Lazarevic V, Schrenzel J, Petrova TV, Pot C. Cell Rep. 2019; 29:378-390. Multiple sclerosis (MS) is a common autoimmune disease of the CNS. Although an association between MS and inflammatory bowel...

Is this the next treatment for MS…If you have psychosis?

We all have heard about BioRXiV (Bioarchive), where people can deposit their preprints before publication on a journal. Now there is not MedRXiv (Medarchive). All that needs to be done is link this up to Pubmed and we can cut out the middle man (publisher). A free archive that is open access and you get rid of the impact factor and the publishing mess in one easy swoop. What’s not to like...

No sooner have we had a Worms trial, but a vitamin D trial is reported. My time capsules are coming home. Maybe my type writter got stuck.

This study reports the trial of vitamin D + beta interferon verses vitamin D and the vitamin D trial fails. In my time capsule, I had this one as a fail too, just as the WORMS study failed to meet its endpoint too. You say I am saying this, after the event, which is true…but my time capsule for microbiome trials were planted about three years ago and they say the same thing. Academics are...

WORMS for MS

This study has been sometime coming and was I think probably originally based on the idea that a worm infection can drive a TH2 (anti-inflammatory) from a TH1 (pro-inflammatory) response. I think there were a number of studies planned, but this study from Nottingham passed the finish line. In this study people were infected with the hookworm parasite and I guess became biobombs as the worms would...

Human MS becomes EAE again, as its T cells that springs out in twin studies

In the new era of preprint papers you can put your stuff online, even before it is reviewed. Todays offering looks at twins, one with MS and one without an MS diagnosis. However when they look at the twin without a diagnosis, they find MRI features that they think could be early MS. These people are in what we call the prodromal phase. In this study they look at the immune component and conclude...

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