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Cladribine 2 Ocrelizumab 1/2

Prof G did a post cladribine 2, fingolimod 0 and there was one for ocrelizumab…this small study supports that result. Anti-CD20 clearly inhibits the antibody response towards the COVID-19 vaccine and and cladribine treated people responding well. All explained by Biology 101, I think. You give vaccine to people after the drug is long gone and what is there to response…responds. Treat...

Ocrelizumab removing oligoclonal bands in a few people within one year

Whilst hunting through the ECTRIMS 2020 meeting I came across this presentation. We have made a hypothesis that ocrelizumab may act as an immune reconstitution therapy with long term-benefit form a short term treatment cycle. We don’t have the data because we don’t have the trial. The manufacturers have little incentive to do such a trial and neuros probably dont want to tread on the...

Injection site reactions COVID-19

The modellers think T cells are the important lymphocyte subset for control of COVID-19. Maybe Good news for the B cell depleters Impairment of T cells’ antiviral and anti-inflammation immunities dominates the death from COVID-19 She, Z.-s., Scholes, G., Zhang, L., Li, R., Song, G.10.1101/2021.04.26.21256093 — Posted: 2021-04-29 Clarifying key factors dominating the immune...

#MSCOVID19. Learning from arthritis….Anti-CD20 antibodies block vaccine responses

We have seen one paper in MS…this is going to be repeated…Why because they use anti-CD20 (rituximab) in MS. In arthritis they are seeing blunting too. Spiera et al. Rituximab, but not other antirheumatic therapies, is associated with impaired serological response to SARS- CoV-2 vaccination in patients with rheumatic diseases . There is a paucity of data on the effect of...

Saving nerves from damage. Protect the cell’s power houses.

Mention New York and you get a picture of the Brooklyn bridge By Suiseiseki – Own work, CC BY-SA 3.0, Mention Neurodegeneration and you get the brooklyn bridge of neurodegeneration. It is this picture showing axonal blebbing (green balloon) where the contents of the nerve escapes, because it has been cut. In the centre of an active MS lesion you can get over 10,000 blebs per square...

#MSCOVID19 Green Book update

For those who have not been vaccinated yet you may be interested in the Vaccine Green Book update. There is info on Pfizer Astrazeneca and Moderna vaccines Click to access Greenbook_chapter_14a_7May2021.pdf Individuals with immunosuppression may not make a full immune response to vaccination.As there is no evidence on response in immunosuppressed individuals there is also noevidence upon which to...

Natalizumab biopsies, is the T cell hypothesis all wrong?

Natalizumab, a recombinant humanized monoclonal antibody directed against the α4 subunit of the integrins α4ß1 and α4ß7, has been approved for the treatment of active relapsing-remitting MS. It has been suggested to work by blocking T and B cells and perhaps monocyte entry into the central nervous system. This inhibits relapsing disease but the side effect seems to expose people to the risk of...

Natalizumab points at the importance of B cells

We and to be fair others, suggested the importance of cells within the memory B cell populations many years ago. The important part of hypothesis building is trying to disprove the idea and I would say that over those years the support has built and built. However, still many people do not accept this. As data builds up and up and eventually a light bulb is turned on. I guess you are bored with...

NORTHERN enLIGHTened? Combating MS from Rituxiland;

Sweden is not only famous for its love of Eurovision Song Contest and Iron Maiden (a strange mix), they are perhaps the Neurological Mavericks. In the dictionary this gives a meaning to be “independent-minded” and so I am being very complementary. Sweden is also home of the Nobel Prize and therefore I am sure they say let the data speak. Rituximab is not a licenced treatment for MS...

Deed Poll for BartsMS Blog

Hello peeps. I need to paint a different picture of myself and in lock down I have not been able to wear a lab coat for ages. I haven’t been able to be a MouseDoctor, which is good news from the beasties, but as you all know I’m not a real doctor. Vincent Mouse The orange COVID mask has cut off my circulation and it made my ear drop off:-). I have my artist outfit on as we are having...

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