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Innate immune response and COVID-19

Having reported on the T and B cells. SARS-CoV-2 and Multiple Sclerosis: Not All Immune Depleting DMTs are Equal or Bad.Amor S, Baker D, Khoury SJ, Schmierer K, Giovanonni G.Ann Neurol. 2020 Jun;87(6):794-797 This time DrLove shows off her immunological knowledge to give some insight into how the innate (macrophages and neutrophils) etc. are involved in COVID-19. Get a cup of Tea, and Relax and...

Overdosing, does this happen with fingolimod?

Overdosing is a current theme in MS treatment and in the era of COVID-19 attention has focus on whether extended dosing intervals could be used. Fingolimod is a once a day treatment but it has a long half-life of about 6-9 days meaning that it take 6-9 days for half the drug to disappear. So do you need to treat every day, it looks like the answer is no, but as ever we need a study . Clinical...

Ozanimod How does it work? Have we got a real clue?

Last week I wrote a post about how pharma may report on the next Cladrimod (cladribine or ozanimod/posenimod) study in “Dr Dooley will be happy that their uncited work from 2016 has been repeated….MS drugs affect memory B cells!”. In that post I made a prediction on how the lymphocyte subset data would be reported from the next MS drug so that the potential for memory B cell depletion...

Q&A August 2020

For those reading on 1 August. Happy Yorkshire Day

Gods Own Country

You know the the drill if you have a question unrelated to the threads. This is the place for you

Ocrelizumab inhibts vaccine responses

Ocrelizumab blunts the vaccination response this is shown in a trial if you want to read about it straight from the Horses mouth you can read below but it is behind a pay wall, if you want to see what was shown you can see it for free here. Baker D, Roberts CA, Pryce G, et al. COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases [published online ahead of print, 2020...

Specificity of oligoclonal bands…Viruses?

Recombinant antibodies derived from laser captured single plasma cells of multiple sclerosis brain identified phage peptides which may be used as tools for characterizing intrathecal IgG response.Kennedy PGE, Graner MW, Walker D, Pointon T, Fringuello A, Yu X.J Neuroimmunol.2020 Jul 14;347:577319. doi: 10.1016/j.jneuroim.2020.577319. Online ahead of print. Oligoclonal bands and...

Dr Dooley will be happy that their uncited work from 2016 has been repeated….MS drugs affect memory B cells!

Part of the scientific process is repetition, but at some point in time you need to believe it and move one. This study is Open access and so you can read it, but it is further supportive evidence of the memory B cell hypothesis Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K. EBioMedicine. 2017;...

Ker ching

ProfG has been asking questions about the prescribing habits of his colleagues and asks why alemtuzumab and HSCT are not being used by some. I wonder if the other end of the spectrum will be questioned and the use of lower efficacy agents. This is going strong Rome BN, Tessema FA, Kesselheim AS. US Spending Associated With Transition From Daily to 3-Times-Weekly Glatiramer Acetate [published...

Remyelination. Is this war amongst scientists?

Remyelination is a hot topic In the paper below they say “The view that differentiation of OPC into mature myelinating oligodendrocytes is required for successful remyelination in humans has been challenged recently. Measuring the integration of 14C derived from nuclear testing into DNA of oligodendroglial lineage cells Yeung et al. suggest that pre-existing oligodendrocytes and not...

How to reduce the time to Siponimod

How to reduce the delay of diagnosing secondary progression in multiple sclerosis. Hernan Inojosa, Tjalf Ziemssen July 22, 2020 Letterhttps://doi.org/10.1177/1352458520943799 Do you have secondary progressive MS?. This article points you to a tool devleoped by Novartis who are the makers of Siponimod . This has been licenced for secondary progressive MS so you need to know when this begins It is...

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