AuthorMouseDoctor

Risk factors for reactivation of clinical disease activity in multiple sclerosis after stopping natalizumab

You can all read the text, natalizumab seems to hold everything in check Risk factors for reactivation of clinical disease activity in multiple sclerosis after natalizumab cessation. Mustonen T BM, Rauma I MD, Hartikainen P MD, PhD, Krüger J MD, PhD, Niiranen M MD, Selander T M.Sc, Simula S MD, PhD, Anne M R MD, PhD, Kuusisto H MD, PhD. Mult Scler Relat Disord. 2019 Nov 5;38:101498...

Another mechanism of damage involving microglia

If a nerve cannot talk to another nerve, problems may occur. Loss of myelin will slow nerve transmission but if there is no synapse (the point where one nerve contacts another nerve) there is no nerve signal transmission. In this study they look at the visual system and they find that synapses are lost, even if there is seemingly no demyelination, They showed that microglia are removing the...

Interferon Beta does not influence Birth weights

The association between exposure to interferon-beta during pregnancy and birth measurements in offspring of women with multiple sclerosis. Burkill S, Vattulainen P, Geissbuehler Y, Sabido Espin M, Popescu C, Suzart-Woischnik K, Hillert J, Artama M, Verkkoniemi-Ahola A, Myhr KM, Cnattingius S, Korhonen P, Montgomery S, Bahmanyar S. PLoS One. 2019; 14(12):e0227120 BACKGROUND: Interferon-beta (IFN...

Understanding MS

If you want to get a view of MS from someone else this is an online review. I am not sure I completly agree with the view point but it is good to get different view points. They argue that MS is a primary degenerative disease (The real MS) and is accompanied by varying degrees of inflammation. Sadly the “Inside-out” (trigger from inside CNS causing cells to enter) and “outside...

HSCT gets rid of T cells

This is open access so for those interested, you can have a read. It says efficacy of HSCT is associated with lost of T cells from the CNS. I guess we could have guessed that this would happen, and one would suspect it should happen with any treatment that works. The study also serves to show that most people don’t give a monkey’s about B cells. Mention only T cells and there is no...

Is aging the problem to the woes of animal experimentation and lack of clinical translation?

There has been a failure to translate ides from animals into human benefit. EAEers either do not care about this, which is one central problem, or sometimes people scratch their heads and try and come up with reasons for this failure. In this study it is suggested that aging is not accomodated in the thought process. This is totally accepted and indeed an aged mouse for example does not handle an...

Dr Ruth. Reports of her Studies

Dr.Ruth hasn’t got the log-in details of the new blog, so she asked me to post this. Dr.Ruth says As some of you may know one of the projects that we have been working on has been a vitamin D study in collaboration with the UK MS Register, called the ‘Vitamin D in people with MS’ study. We want to thank all of the participants who took part in this – those who filled out questionnaires, or...

Happy Crimbo

What are you doing reading the blog today, you should be tucking into your Christmas pud or your favourite holiday treat.Yesterday I found a new use for a wheelchair. Meet my new friend Robbi on their new perch. Robbi is happy that he/she are not a pheasant….who are currently being blasted by shotgun-toting nobodies. If you really want to kill a pheasant it is easier to get in a car and run...

Diagnose and Treat Early

As you know, I don’t like CRAB drugs becuase I don’t think they are effective enough for most people, Never have never will. but obviously I respect people’s choice for these agents. However if you go down this route , this is yet another example of treat early, wait too long and damage is done, meaning that it is less likely that you can get disease undercontrol. Early...

Translate

Categories

Recent Posts

Recent Comments

Archives