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Microbiome Research Where will it lead us?

ProfG loves throwing a spanner in the works to get you thinking and keeping us on our toes. However, I have been charstisted for my outspoken views that many of my peers are unthinking lemmings that follow the masses jumping off the intellectual cliff. Microbiome is the answer to autoimmunity is a current dogma and you are spending millions of pounds doing trial after trial in every human disease...

Not All Data is Created Equal. Brain Atrophy

ProfG has put an interesting question about whether DMT are all born equal. Whilst the influence on relapse rates is much clearer in terms of the hierarchy, the effects on brain atrophy has led ProfG to ask a sensible question. It was suggested that HSCT and alemtuzumab are up there at the top of the pile in the atrophy states, leaving the B cell therapies in their wake. B cell therapies are...

Blood cells clearing up the myelin damage..

Zhou T, Zheng Y, Sun L, Badea SR, Jin Y, Liu Y, Rolfe AJ, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw TL, Wu W, Wang G, Ren Y. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nat Neurosci. 2019 Jan 21. doi: 10.1038/s41593-018-0324-9. [Epub ahead of print] The clearance of damaged...

Making new myelin, have animal studies been sending us in the wrong direction?

You all know that you can assess how old a tree is by counting the growth rings. You all have heard on carbon-dating, whereby you can assess the age of living things that have died. This works because living things are made of carbon containing molecules. Carbon comes in a radio-active form called carbon fourteen (related to the number of atoms and electrons in the molecule). This is decaying to...

Lumbar Puncture Headache…The answer is not age and sex…It’s your needle!

We have been talking about dinosaur neurologists and asking can they learn and change pratice? Prof G and DrRuth will be tearing their hair out with dispare on reading this. It will be disappointing that we are not listening and learning. Post-lumbar puncture headache: an adverse effect in multiple sclerosis work-up. Vecchio D, Naldi P, Ferro V, Comi C, Leone MA, Cantello R.Neurol Sci...

Think Hand but now see it

We have been talking about saving hand function, but can we get an understanding of why hand function. The imagers have been looking and they BACKGROUND:: Hand motor impairment has considerable effects on daily-life activities of patients with multiple sclerosis (pwMS). Understanding its anatomo-functional substrates is relevant to provide more specific therapeutic interventions...

Slowing conversion to SPMS, why we need Neurological Chicxulub for MS

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. Brown JWL, Coles A, Horakova D, Havrdova E, Izquierdo G, Prat A, Girard M, Duquette P, Trojano M, Lugaresi A, Bergamaschi R, Grammond P, Alroughani R, Hupperts R, McCombe P, Van Pesch V, Sola P, Ferraro D, Grand’Maison F, Terzi M, Lechner-Scott J, Flechter S, Slee M...

HSCT is highly Effective

In this study the results of a randomisation non-ablative HSCT stem cell therapy compared to current DMT and it does better. Much better This is not surprising we know that immune depleteion is effective. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis A...

EAE Cure of the Week…Plasma cells protect MS

As profG and NDG gear up to do a study to try and get rid of antibodies from the brain, I read with horror the latest effort of microbiome in animal models in a world premier journal.  It says plasma cells make MS better! So should we abandon the trial? I was worried so I thought I best have a look at the data. As you know I don’t think that studies of B cells in mice tells us much and...

Targeting B cells Slows Progressive MS…..Wakey, Wakey People monotherapy is so last century.

In the News today CD20-Depletion appears to have benefit is SPMS… But what does it say to me? Time to start learning and acting on the knowledge! Naegelin Y, Naegelin P, von Felten S, Lorscheider J, Sonder J, Uitdehaag BMJ, Scotti B, Zecca C, Gobbi C, Kappos L, Derfuss T. Association of Rituximab Treatment With Disability Progression Among Patients With Secondary Progressive Multiple...

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