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#MSCOVID Information for Health Care Professionals

If you are a HCP professional you may be interested to read the experience of some HCP from China. The handbook focuses on the real-time hotspots of the COVID-19 epidemic. It provides detailed and comprehensive answers to potential questions for diagnosing and treating patients in different types. Treatment methods to treat the critically ill Efficient clinical decision-making strategies for...

Drug induced lymphopenia and evidence of infection

I will just put this up without to much discussion but it suggests that the lymphopenia associated with dimethyl fumarate and fingolimod are not really linked to noticably higher infection rates in the real world setting. This view has been repeated for many other agents that blood cell numbers do not appear to correlate with disease activity. Now it may be if you drill down on specific subsets...

It is harder to be a drummer if you have progressive MS.

We have been making the argument that we have to #thinkhand, notably when we do clinical trials in MS. This is based on the idea that the problems in MS are related to thelength of the nerve tracts, so if you ge lesions anywhere in the nervous system, the longer nerve tracts are more likely to get a lesion and the more lesions you get in a tract the more likely that disability occurs. Eventually...

#COVIDMS. Breakfast COVID.

There has been terrible news, so don’t choke on your breakfast. What is it…No….Not that the latest trial on an anti-virals has failed…you are desensitized to failed trials:-). You guys are used to that but did you know The Restaurants and Pubs have been closed!!! So now you can’t make anymore of those jokes about me and MD2 nipping down the road for a Swifty…...

#COVIDMS The need for testing and isolating

We are failing, not just because health case systems are being over run, but the tragedy is that we have stopped testing and so do not know who has got the virus and who has not. This study based on modelling suggests that about 86% of the people infected are not being detected because their symptoms are very mild and so they go unnoticed. At present we are essentially capturing the people who...

#COVIDMS Immune Response of a COVID Survivor

So what is important for the immune response to COVID? In this COVID survivor we see the kinetics of the immune response as it generates after infection. To me it is as expected. It is a combination of T and B cells and the innate (monocytes etc). immune response and occurs according to Immunology 101. B cell responses take a few days to generate and antibody producing cells are elevated by about...

#COVIDMS BreakfastCOVID

Arni….What’s this got to do with COVID Self-isolation? or Is it living with animals is how soo many of the human viral infections start. However, probably nothing. But when I say the story below, with my dyslexia, I read donkeys and thought about a post about Arni (above) and the old days when they used to use horses to make antibodies. They would infect horses with virus, bacteria...

#COVIDMS MS Register COVID survey

Thanks you to all pwMS that have completed the COVID-19 survey so far. That is an incredible response is less that 24hours. They need more people to share there what is happening though, so please login/sign up NOW Check regularly for updates

#COVIDMS The Curse and Course of COVID. How are you doing?

There are reports of people with MS doing well on COVID that is great, but it is important that you understand the course of COVID and there are essentially two parts…The good bit and then for some the bad bit or the really bad bit. Following the initial infection there is a period, seems to be about a week when the virus is escaping immune suveillance and probably all is well and not too...

How Does Rituximab Work

Clustering for the kill Cluster of differentiation 20 (CD20) is a membrane protein that defines most B cell populations and is the target of therapeutic antibodies to treat malignancies and autoimmune disorders. The structure of CD20 bound to the antibody rituximab that activates the complement system (a cascade of enzymes that punch holes in their target to kill them) to kill B cells. CD20 forms...

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