AuthorMouseDoctor

COVID Breakfast…MS research diverted elsewhere

COVID-19 has diverted resources away from MS research and it has diverted people away from MS research….Who knows what the consequences will be. Many people could not get in labs unless they did COVID work, and some weren’t allowed in until they had got grants to do COVID work, others were allowed to spend their grants on covid work. Some people worked on COVID so they could do their...

#MSCOViD19 Vaccine readiness

Its not the level of depletion, its the duration and persistent B cell depletion that is an issue Normal antibody response after COVID-19 during treatment with cladribine.Celius EG.Mult Scler Relat Disord. 2020;46:102476. doi: 10.1016/j.msard.2020.102476. Online ahead of print.PMID: 32882501 Fernández-Díaz E, Gracia-Gil J, García-García JG, Palao M, Romero-Sánchez CM, Segura T. COVID-19 and...

Withdrawn…Why?

Retraction of Publication Rev Neurol (Paris). 2020 Sep 15;S0035-3787(20)30660-3. doi: 10.1016/j.neurol.2020.08.001. Online ahead of print. WITHDRAWN: Incidence and mortality of COVID-19 in Iranian multiple sclerosis patients treated with disease-modifying therapies DOI: 10.1016/j.neurol.2020.08.001 The most damming report of anti-CD20 risk of MS has been withdrawn by the...

Faster ocrelizumab infusions appear to be safe

Vollmer TL, Cohen JA, Alvarez E, Nair KV, Boster A, Katz J, Pardo G, Pei J, Raut P, Merchant S, MacLean E, Pradhan A, Moss B. Safety results of administering ocrelizumab per a shorter infusion protocol in patients with primary progressive and relapsing multiple sclerosis. Mult Scler Relat Disord. 2020 Aug 18;46:102454. COVID-19 has focused attention to the amount of time people are kept in the...

Will the mechanistic SH1 ever stick? or will we have more failed MS studies?

Today is hard core science day. We can learn a bit together. You can learn a lot for the human experiment, which is the clinical trial. Success of trial points the finger at something important, but failure can too. We thought what works in arthritis (MS of the Joint) would work in MS (arthritis of the brain). That was until we tried tumour necrosis factor (TNF) inhibitory activity. It is...

Cladribine may not work well in everyone.

There are some people who do not respond to drugs. This can be for genetic reasons. There are people who do not deplete after treatment with alemtuzumab. There will be people that on’t respond well to rituximab/ocrelizumab and there are people that will not respond to cladribine. If you don’t deplete the lymphocytes, the drug may not work. So it is always improtant to monitor this...

In mourning and licking my wounds…but the CRAB drugs are amazing and all made out of stardust:-)

Yesterday I was involved in a debate “Anti-CD20 therapies should be used as Immune Reconstitution Therapies rather than maintenance therapies“. I feel that I got a preverbial ass-kicking and the audience favoured keeping the status Quo and treating with anti-CD20….forever. My take was that the biology and preliminary data is reasonably clear but we need a trial to address the...

Cladribine failures after fingolimod

Fingolimod traps lymphocytes in the bone marrow and lymph glands and causes depletion in some individuals. The problem is that when you come off fingolimod, how long do you wait before starting the next treatment? Wait too long and you get disease rebound, as occurs with natalizumab also, which is a mega relapse. Here are three individuals swapped onto cladribine. However, don’t wait long...

Cladribine depletes memory B cells…But Hey. So do a number of MS treatments

What happens to T and B cells after oral cladribine. This has all been reported for T cells before…so who cares…..Only joking, However we know what will happen. T cells drop by 50% in year one and more in year 2. However, this study points the finger away from CD20 T cells that some people are so desparate to show how ocrelizumab works. Th17 T cells drop and there is a suggestion that...

#MSCOVID19-Oldies Respond to vaccine..Good news for MS

The race is on for a vaccine for the general public. The USA has COVID Operation Warp speed. However, they have lost the race, just as they came second in the Space Race…..Yuri Gagarin beat NASA to be the first person in Space and the Russians beat the World with the first satellite…..Sputnik. The Russians already have a vaccine that they have licenced. They have called it Sputnik V...

Translate

Categories

Recent Posts

Recent Comments

Archives