AuthorMouseDoctor

Same again from Sweden…The Hare arrives

This first surfaced many moons ago on SSRN as a preprint when only people taking anti-CD20 who were naturally infected were included. It suggested that most people made an anybody response when infected with SARS-CoV-2 (Only about 25% seroconverted on anti-CD20 (which has been shonw by many others) and not on anti-CD20) and that vaccines were not going to be a problem….How wrong that turned...

Mousey COVID lessons

You said Any thoughts on this study out of Yale? Israelow B, Mao T, Klein J, Song E, Menasche B, Omer SB, Iwasaki A. Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2. bioRxiv [Preprint]. 2021 May 19:2021.05.19.444825. doi: 10.1101/2021.05.19.444825. PMID: 34031656; PMCID: PMC8142653. in sciece immunology What are implications for MSers and those on anti...

DMF on trial in PPMS

Recently ProfG has been singing the praises of Nrf2 modulators as useful targets….but the proof is in the pudding. Here we have a DMF, a well known Nrf2 modulator, trial and and the taste of the pudding does not seem good. It is looking in PPMS and using neurofilament as the outcome and there is nothing positive to say, I am sorry to say. However, I think the issue is neurofilament light...

Novartis what is happening with the imods and COVID-19?

The rule number one of fight club is dont talk about fight club!…..Rule number one of pharma club is don’t SH1 on your own product!…..OK to paraphrase….Do not highlight any issues, but there is one Big Issue I want to know about and it has nothing to do with being homeless. Sales for anti-CD20 have been doing fantastically well and it was all rosey and everyone loved it...

Lumping the immunosuppressed together gives a good result, drill down and there are too few of the problematic groups to raise alarm bells for the bean counters. More data reporting seroconversion problems with anti-CD20 but again a T cell response.

The government has done some mega studies on immunosuppressed people but their focus is on cancer and solid cancers and the message comes back that most people seroconvert. This allows the bean counters to be happy, but it tells me that as we move forward, we should focus attention on anti-CD20 treated individuals for MS. Whether the scientists can do this I wonder as they focus on their area of...

Q&A September

As autumn arrives things turn gold

Gold fish

Sculpture from the East End of London

Disclaimer: Please note that the opinions expressed here are those of the author and do not reflect the positions of the Barts and The London School of Medicine and Dentistry nor Barts Health NHS Trust or Queen Mary Univeristy of London.

Ok so now we know T cells after CD20 but blunted antibody response again

It is clear people with MS make a T cell response even on anti CD20. Many make an anti spike antibody response but tend to make less neutralising response against the receptor binding domain of spike.. What does it mean?….I think it means you are at a greater risk of symptomatic covid 19 if you are on anti CD 20 and don’t make an antibody response. I think even in those that do…...

MSCOVID-19 Importance of antibody production to prevent infection.

Although we have made the case that antibodies may not be essential to deal with the virus, it is clear that antibodies are centrally important in limiting infection. This can be seen in this Russian study. If you made antibodies after infection you did OK and much better than if you only made T cell responses Ivan Molodtso et al .A prospective study of the protective effect of SARS-CoV-2...

Brutons Tyrosine Kinase Inhibitors for Relapsing MS

The race is on between the different Pharma to get their Brutons tyrosine kinase inhibitors into the clinic. There are at least four different variants in the hunt and most are been tested in phase III studies in relapsing and progressive MS. They inhibit B cell activation so perhaps unsurprisingly they inhibit relapsing MS and this can be shown within a few weeks using MRI outcomes, as shown...

MSCOVID19 more of the Same Old, Same Old

So it is becoming more and more clear that some form of T cell response is made after COVID-19 infection even if you dont make a B cell repsonse if you have been treated with anti-CD20 and this is reflected in what we see after vaccination. What are we going to do with this information….it seems like the answer is nothing…at the moment. Iannetta M, Landi D, Cola G, Malagnino V, Teti...

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