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#MSCOVID19 Goes Dutch

Here is the Dutch experience. Here, we provide an extensive overview of all reported COVID-19 cases in multiple sclerosis (MS) patients in the Netherlands between 27 February and 9 June 2020, gathered by the Dutch MS Taskforce of the Netherlands Society of Neurology. A total of 86 MS patients were reported, 43 of whom tested positive for COVID-19. Of 43 patients who tested positive, 22 patients...

Don’t Get MS under control and you lose Brain!

WBV = whole brain volume This is the extension study of ocrelizumab when people who had taken beta interferon were switched onto ocrelizumab and compared to ocrelizumab. You can read what the medical writer, drafted for the authors, I mean drafted in response to the input from the authors:-). You can have a read, but the important point is this the brain volume lost in the 2 years of being put on...

Progresssive trials its all sorted or is it?

Serum neurofilament light as a biomarker in progressive multiple sclerosis.Kapoor R, Smith KE, Allegretta M, Arnold DL, Carroll W, Comabella M, Furlan R, Harp C, Kuhle J, Leppert D, Plavina T, Sellebjerg F, Sincock C, Teunissen CE, Topalli I, von Raison F, Walker E, Fox RJ.Neurology. 2020 Jul 16:10.1212/WNL.0000000000010346 There is an unmet need in multiple sclerosis (MS) therapy for treatments...

COVID Breakfast

Get rid of your cornflakes this morning and if you want to survice COVID-19 eat cabbage and cucumber. COVID-Cure What should we research next? Association between consumption of vegetables and COVID-19 mortality at a country level in Europe. Fonseca SC et al. MedRXiv doi:  Background Many foods have an antioxidant activity, and nutrition may mitigate COVID-19. To test the potential role of...

Are you lucky to have autoimmunity with alemtuzumab

Development of autoimmune thyroid disease in multiple sclerosis patients post-alemtuzumab improves treatment response.Sovetkina A, Nadir R, Scalfari A, Tona F, Murphy K, Rigoni E, Dorsey R, Malik O, Nandoskar A, Singh-Curry V, Nicholas R, Martin N.J Clin Endocrinol Metab. 2020 Jul 15:dgaa453 Context: Alemtuzumab is an anti-CD52 monoclonal antibody used in the treatment of relapsing...

#MSCOVID19 It’s not T-time is M-time. Alemtuzumab shows more evidence to support a major role for the macrophage

You do not need peripheral B cells in the blood to fight COVID-19 so does that mean it is T-time for the T cells to get rid of COVID-19. Woo, M.S., Steins, D., Häußler, V. et al. Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients. J Neurol (2020). . There are no B cells and no anti-SARS-Cov2 antibodies If they had read our paper…… The...

#MSCOVID19. CD20-antibodies will take time to be optimally vaccine ready.

COVID‐19 vaccine‐readiness for anti‐CD20‐depleting therapy in autoimmune diseases David Baker, Charles AK Roberts, Gareth Pryce, Angray S KangMonica Marta, Saul Reyes,Klaus Schmierer, Gavin GiovannoniSandra Amor. Clin Exp Immunol Although most autoimmune diseases are considered to be CD4 T‐cell or antibody‐mediated, many respond to CD20‐depleting antibodies that have limited influence on CD4 and...

EBV B cells make mice worse

This is ProfG’s turf, but MD2 pointed this one out and said what do you make of it?…I dont’t its profGs turf You have every thing here…EBV, microbiota, relapse what more do you want?…Replication I guess Epstein Barr virus-immortalized B lymphocytes exacerbate experimental autoimmune encephalomyelitis in xenograft mice.Polepole P, Bartenslager A, Liu Y, Petro TM...

If you don’t try you can’t fail. Laquinimod bites the dust

You say why dont you lot do anything for PPMS, if you don’t try, you can’t fail. Laquinimod was a rather useless DMT as far as relapsing MS was concerned and it was pitted against beta interferon in a trial and it lost, but it looked like if affected brain volume. So a trial in PPMS was done and here are the results….Sorry trial has failed. Sadly this could have been the perfect...

Trials of MS treatments in Children What do you think?

This week I did a Digesting Science with children/young adults who had MS/Demyelinating disease about the impact of COVID-19 on DMT that was organised by Alison. I learned that I am useless at Origami and my Immune Cell was rubbish….but I’ll let Alison explain all that. Children with MS need treatment, so what should we use and how should we test agents?. I have lifted this debate...

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