AuthorNeuro Doc Gnanapavan

Exercise, Exercise, Exercise

It’s possible if repeated enough times it may actually turn out to be true and not end up being a one ‘big lie’. Keeping on the COVID theme, how many of you have heard of COVID-15? COVID-15: The 15 lbs of weight gain caused by nervously binge eating your COVID-19 food stockpile. Jokes aside, evidence points to exercise being beneficial for not only boosting your metabolism (and...

Alemtuzumab replay

Sometimes it’s better the devil you know than the one you don’t. Alemtuzumab came into disfavor following the European Medicines Agency (EMA) Article 20 procedure surrounding certain rare side effects. There couldn’t have been a deeper grave to crawl out of. In my mind the group most to gain from alemtuzumab have always been those early on in their disease before disability sets...

EBV or not

The umpteenth study on causality means very little if it is not scientifically plausible. This is core science, and it’s what real scientists work on. EBV infection has long been strong contender for the development of MS. But, how strong is this link? What does having had EBV as a teenager do to your biological makeup (i.e. endophenotype)? In a first study of its kind the Swedish group...

Age is a compelling causal argument for MS

Fact – autoimmune disorders affect the young. Fact – the immune system ages with you as does rest of the body. Fact – MS is an autoimmune disorder. This week we find yet another study re-iterating the point that the evolution of MS lesions is an age-dependent phenomenon. This time using MRI head scans, in what is arguably one of the largest series published on the topic...

Modern MS, the German perspective

Admittedly research into MS has grown in depth and breath over the years. For those affected and the recently diagnosed the temptation to fit oneself to the average data set is too tempting to say the least. The latest installment in ‘modern MS’ comes from our German colleagues across the pond (see Abstract at the bottom). They report that– Highly active MS is uncommon ~8.5% in...

The genetic code

I like to think that we’re all more than some of our parts. But, our genetic code has us all fooled. Each and every cell has a genetic code that come to think of it probably has a lot more to say about our lives before, now and after than we’d truly like. We don’t debate that genetics have a role to play in the development of cancer, but MS has always proven to have a complex...

The COVID lockdown

Shall I mention herd immunity? Approximately 90-95% of the population needs to be infected with COVID-19 before herd immunity is achieved. China, Germany and Italy have been mass testing in feverent hope of this happening. Their have been the obvious set backs – lack of testing kits for one, and then the logistical issues; not being able to do the number of daily tests needed to capture the...

Hydroxychloroquine top trumps COVID?

Donald Trump grilled over continued promotion of hydroxychloroquine Surprisingly or unsurprisingly, on the back of Donald Trumps continued promotion of hydroxychloroquine, the US Food and Drug administration has said that it will allow the use of antimalarials, such as hydroxychloroquine and chloroquine for the treatment of COVID19. The additional indication was approved on April 7 under...

COVID19 reality bites

Hats off to our Italian colleagues – I can only imagine what each day has brought into your lives. Last weekend, I held the notorious position as the last Consultant Neurologist on-call for Barts Health, one of the largest NHS Trusts England with 1,255 A&E patient attendances per day. Monday onward, every able bodied member of staff has been redeployed to a major incident rota, the...

The COVID19 brain

Letter by British Rhinological Society and Ear, Nose & Throat UK Although severe acute respiratory syndrome (SARS) has been the hallmark of severe COVID19 infection, anosmia (lack of smell) and hypogeusia (the reduced ability to taste), headaches/dizziness have also been reported. Is COVID19 neurotropic? We don’t have hard data to support/refute this beyond history from those so far...

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