AuthorNeuro Doc Gnanapavan

Stuck in a loop

Starting certain MS drugs may get you stuck in a loop that you never bargained for when you started them in your early thirties or forties. The ability to stop taking drugs at an older age is something we more or less take for granted, especially if we have been disease free for ‘X’ many years. However, in the MS world things are never that simple or straightforward; there is...

Will the real slim-shady please stand up?

Vitamin D is one of the biggest confounders in MS clinical trials. It’s like a chess piece, where every move has an effect on the outcome. This latest piece of research from Romania studying the effect of Copaxone (immune modulator) versus prednisone (steroid) on circulating immune complexes (auto-antibodies) in RRMS, shows exactly this. The investigators found low serum levels of immune...

Mind matters

New research from Brazil suggests that the act of walking when you have MS uses up greater cortical resources than if you don’t have MS; especially in the frontal and parietal cortical areas. Their hypothesis is that this increased activity is a compensatory response for the subcortical damage that occurs with MS. This is a plausible as majority of MS lesions occur in a periventricular...

Social media is not media

Facebook, Twitter, Instagram, Tik Tok create an escapist persona for many of us staged by influencers, experts and self help gurus. It is the first thing that we check in the morning and the last thing we glance at before dropping off to sleep. Research has shown that we spend more time on social media sites than actually making true human connections. However, having an illness isolates you like...

The age of innocence

Once upon a time there was a boy. He lived in a well-to-do neighborhood, had everything that he needed, his parents loved him and everything was possible. One day whilst playing football his leg gave way and he could no longer walk like his mates. This was the start of his journey into MS and adulthood. Age matters in MS. Pediatric MS typically refers to the development of MS before 18 years of...

Let’s get ready to rumble!

If the heavy weights of MS drugs go head to head in the boxing ring, it is anyone’s guess who will come out on top. The MS Base publication in 2019 states that starting on fingolimod, alemtuzumab or natalizumab is superior to glatiramer acetate or interferon beta. This March, the Italians have sneakily put together their own contest between fingolimod and natalizumab. You may say this one...

A literal pain in the face

Trigeminal neuralgia (TN) is an excruciating shooting pain involving one or both sides of the face; occurring in isolation (also termed idiopathic) or as a symptom of MS or other neurological disorders. It is literally a pain for both the patient and the doctors who manage it. The only plus point is that it is episodic in nature. However, with any recurrence you are pretty much starting again at...

Now you see it, Now you don’t!

Obesity or high BMI and raised cholesterol have all been linked to an increased risk of multiple sclerosis. This is of particular concern in the Western world as obesity is fast becoming the single major determinant of an individuals health quotient. But, how far should we take this in MS? In a large study of 14802 MS cases and 26703 control, a group in San Francisco set about looking for a link...

Treating MS in an ageing population

Image from MSARDs As the entire world learns to embrace ageing, it brings with challenges for healthcare service delivery and economy. Although, MS is a disease of the young (median age of onset is 32) ageing looms in the horizon and cannot be blithely ignored. In some instances, the MS isn’t picked up until much later (the oldest patient I’ve diagnosed is 84 years old!), which raises...

Life is short, may your telomeres not get shorter

As cells divide, chromosomes replicate so that each cell contains the full complement of genetic material required for it to work. Telomeres are stretches of genetic material that are found at the ends of chromosomes protecting it from damage. There are a few interesting facts related to telomere length: 1) telomere length shortening is believed to be a major contributor to ageing; 2) telomere...

Translate

Categories

Recent Posts

Recent Comments

Archives