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Reconstitution with fingolimod is not always quick

Ghadiri M, Fitz-Gerald L, Rezk A, Li R, Nyirenda M, Haegert D, Giacomini PS, Bar-Or A, Antel J.Reconstitution of the peripheral immune repertoire following withdrawal of fingolimod Mult Scler. 2017;23(9):1225-1232. doi: 10.1177/1352458517713147. BACKGROUND:Following fingolimod cessation, immune reconstitution or lack thereof may have consequences for disease rebound or safety of commencing...

Breast Feeding is Better

Breastfeeding, ovulatory years, and risk of multiple sclerosis.Langer-Gould A, Smith JB, Hellwig K, Gonzales E, Haraszti S, Koebnick C, Xiang A. Neurology. 2017 Jul 12. pii: 10.1212/WNL.0000000000004207. doi: 10.1212/WNL.0000000000004207. [Epub ahead of print] OBJECTIVE:To determine whether women who breastfeed their infants longer or have fewer ovulatory years are at lower risk of developing...

Natalizumab helps maintain quality of life

Foley JF, Nair KV, Vollmer T, Stephenson JJ, Niecko T, Agarwal SS, Watson C. Long-term natalizumab treatment is associated with sustained improvements in quality of life in patients with multiple sclerosis. Patient Prefer Adherence. 2017;11:1035-1048. BACKGROUND:Multiple sclerosis (MS) patients experience lower health-related quality of life (HRQoL) than the general population. In...

Active EBV cause Attacks?

Serafini B, Scorsi E, Rosicarelli B, Rigau V, Thouvenot E, Aloisi F. Massive intracerebral Epstein-Barr virus reactivation in lethal multiple sclerosis relapse after natalizumab withdrawal.J Neuroimmunol. 2017 Jun 15;307:14-17 Rebound of disease activity in multiple sclerosis patients after natalizumab withdrawal is a potentially life-threatening event. To verify whether...

Overdosing with Natalizumab

van Kempen ZL, Leurs CE, Witte BI, de Vries A, Wattjes MP, Rispens T, Killestein J. The majority of natalizumab-treated MS patients have high natalizumab concentrations at time of re-dosing.Mult Scler. 2017 May 1:1352458517708464. BACKGROUND:Natalizumab is efficacious in the treatment of relapsing-remitting multiple sclerosis. All patients receive the same treatment regimen of 300 mg every...

MS ProDrome

Wijnands JMA, Kingwell E, Zhu F, Zhao Y, Högg T, Stadnyk K, Ekuma O, Lu X, Evans C, Fisk JD, Marrie RA, Tremlett H. Health-care use before a first demyelinating event suggestive of a multiple sclerosis prodrome: a matched cohort study. Lancet Neurol. 2017  pii: S1474-4422(17)30076-5 BACKGROUND:Degenerative processes in neurodegenerative diseases can start years before clinical...

New outcomes for Progressive MS in a Year

Inglese M, Petracca M, Mormina E, Achiron A, Straus-Farber R, Miron S, Fabian M, Krieger S, Miller A, Lublin F, Sormani MP. Cerebellar volume as imaging outcome in progressive multiple sclerosis. PLoS One. 2017 Apr 24;12(4):e0176519. BACKGROUND AND PURPOSE: To assess whether cerebellar volumes changes could represent a sensitive outcome measure in primary-progressive MS.MATERIAL AND METHODS:...

Heart Failure during Relapse

Androdias G, Bernard E, Biotti D, Collongues N, Durand-Dubief F, Pique J, Sanchez I, Delmas C, Ninet J, Marignier R, Vukusic S. Multiple sclerosis broke my heart. Ann Neurol. 2017. doi: 10.1002/ana.24935. [Epub ahead of print] We report 5 cases of acute heart failure (AHF) related to multiple sclerosis (MS) relapses. AHF was inaugural in 3 patients, always preceded or accompanied by signs of...

AAN News A Trial Too Short…ASCEND raises the view that Nataizumab really did work in Progressive MS

ASCEND Phase 3 Trial Open-Label Extension Study Results: Natalizumab May Delay Disability Progression in Secondary Progressive Multiple Sclerosis (SPMS)  Hans-Peter Hartung , Douglas Arnold, Mark Freedman , Eva Havrdova , Douglas Jeffery , Raju Kapoor , Aaron Miller , Finn Sellebjerg , Haihong Li, Nisha Lucas, Diego Cadavid, Nolan Campbell, Pei-Ran Ho, Deborah Steiner Objective: To...

Mosquitos leads us to more evidence for the memory B cells at centre stage for the causal pathway to MS.

In the week that began with a bit of Fake News about the cause of MS, and it ends with something that is perhaps related to the cause,  but two “Cause” stories in a Week are not going to make it in the News.  Why do I say cause, because this is Genetics and this is the predisposition of Risk. So what have B cells got to do with Mosquitos? Read on Overexpression of the...

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