AuthorRam

No Association with Vitamin D Gene

Ban M, Caillier S, Mero IL, Myhr KM, Celius EG, Aarseth J, Torkildsen O, Harbo HF, Oksenberg J, Hauser SL, Sawcer S, Compston A. No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol. 2012 doi: 10.1002/ana.23833. [Epub ahead of print] An association has previously been reported between susceptibility to multiple sclerosis and the rare mutant...

Vitamin D as a protective factor in multiple sclerosis

Salzer et al. Vitamin D as a protective factor in multiple sclerosis. Neurology. 2012 Nov 20;79(21):2140-5. doi:10.1212/WNL. 0b013e3182752ea8. OBJECTIVE: To examine the association between 25-hydroxyvitamin D (25[OH]D) levels and the risk of multiple sclerosis (MS) in blood samples collected prospectively and during gestation. METHODS: In this nested case-control study, 2 population-based...

What do we know about the genetics of MS?

Epub: Watson CT, Disanto G, Breden F, Giovannoni G, Ramagopalan SV. Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs. Sci Rep. 2012;2:770. Epub 2012 Oct 25. Multiple sclerosis (MS) is a complex disease with underlying genetic and environmental factors. Although the contribution of alleles within the major histocompatibility complex (MHC)...

Protein-protein interactions

Epub: Ragnedda et al. Protein-protein interaction analysis highlights additional Loci of interest for multiple sclerosis. PLoS One. 2012;7(10):e46730. doi: 10.1371/journal.pone.0046730. Genetic factors play an important role in determining the risk of multiple sclerosis (MS). The strongest genetic association in MS is located within the major histocompatibility complex class II region (MHC), but...

Whole genome epigenetic profiling- First steps for the Predict MS Study

Over the last 50 years, every newborn has their heel pricked onto filter paper (called Guthrie cards) to screen for diseases such as phenylketonuria, cystic fibrosis, and sickle cells disorders. After testing these Guthrie cards are stored indefinitely in the NHS and in many other countries across the world.  In a study published today, Team G have shown that epigenetic information stored on...

Research: Vitamin D deficiency and EBV before MS onset

Epub: Decard et al. Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2012 Aug 11. Objective: Vitamin D deficiency and Epstein-Barr virus (EBV) infection may be associated with the development of MS. We investigated serum 25-hydroxyvitamin D (25-OH-D) levels and anti-EBV immunoreactivity...

Research: MS and other autoimmune diseases

Marrie RA et al. The Incidence and Prevalence of Thyroid Disease Do Not Differ in the Multiple Sclerosis and General Populations: A Validation Study Using Administrative Data.Neuroepidemiology. 2012;39):135-142. Background: Prior studies of a possible increased risk of autoimmune thyroid disease (AIT) in multiple sclerosis (MS) are inconsistent. We aimed to validate and apply administrative case...

Research: Vitamin D receptor and MS

Epub: Disanto et al. Vitamin D receptor binding, chromatin states and association with multiple sclerosis. Hum Mol Genet. 2012 May 16. Both genetic and environmental factors contribute to the aetiology of MS. More than 50 genomic regions have been associated with MS susceptibility and vitamin D status also influences the risk of this complex disease. However, how these factors interact in...

MS Genes and B Cells

Genomic regions associated with multiple sclerosis are active in B cells. More than 50 genomic regions have now been shown to influence the risk of multiple sclerosis (MS). However, the mechanisms of action, and the cell types in which these associated variants act at the molecular level remain largely unknown. This is especially true for associated regions containing no known genes. Given the...

Vitamin D Reduces Disease Activity in MS

Epub ahead of print: Soilu-Hänninen et al. A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon β-1b in patients with multiple sclerosis J Neurol Neurosurg Psychiatry. 2012 Feb 22. Objectives: To study the safety and efficacy of vitamin D3 as an add on therapy to interferon -1b (IFNB) in patients with multiple sclerosis (MS). Methods: 1 year...

Translate

Categories

Recent Posts

Recent Comments

Archives