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Vaccine Trumpism for President!

A pneumonia might not sound like something you necessarily want to avoid in life, or not something that ‘coughs’ you awake. However, outcome data on pneumonia in non-hospitalised individuals do indicate it’s not a benign condition. A large study in Germany showed a 30-day mortality of 6.3%. Obviously, this was mainly driven by age (mortality was 2.2% below 65 years old) and nursing home status...

RUN SIZOMUS RUN!

Mama Always Said, Life Was a Box of Chocolates. You Never Know What You’re Gonna Get – Forrest Gump, 1994  A few years back Prof G, whilst talking about MS at a conference was approached by Takeda Pharmaceuticals on whether we would be interested in targeting plasma cells; probably one of the last frontiers in MS. The ideas started spinning from there. Roll forward a few years, after...

AAN2021 T cell response in COVID-19 infected people treated with CD20 antibodies.

As profG has made the post here is the data First up we have Asplund Högelin, Klara and Ruffin, Nicolas and Pin, Elisa and Månberg, Anna and Hober, Sophia and Gafvelin, Guro and Grönlund, Hans and Nilsson, Peter and Khademi, Mohsen and Olsson, Tomas and Piehl, Fredrik and Al Nimer, Faiez, Development of Humoral and Cellular Immunological Memory Against SARS-CoV-2 Despite B-Cell Depleting...

AAN 2021. Ocrelizumab overdosing?

Why was ADIOS a no brainer?…..Perhaps because it was going to work! ProfG with a non-fully functioning, non-productive brain can see the logic of ADIOS, hopefully you can see the value of ADIOS, but can other Neuros see it? In some instances I’m afraid not…..I did a debate to young neuros and had my ass-kicked by my opponent. I gave them more data than you can shake a stick at...

Thinking about switching.

Switching from fingolimod has an impact on ocrelizumab Signoriello E, Lus G, Bonavita S, Lanzillo R, Saccà F, Landi D, Frau J, Baroncini D, Zaffaroni M, Maniscalco GT, Curti E, Sartori A, Cepparulo S, Marfia GA, Nicoletti CG, Carotenuto A, Nociti V, Caleri F, Sormani MP, Signori A. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the...

MDs Delayed Saturday mid morning Snack/COVID lunch

P.S. ProfG has a sense of humour and has not taken offence by the contents of this post So for this/last weeks tasting menu we start with Alemtuzumab and antibody responses…I predict good news based on natural infection Iovino A, Olivieri N, Aruta F, Giaquinto E, Ruggiero L, Spina E, Tozza S, Manganelli F, Iodice R. Alemtuzumab in Covid era. Mult Scler Relat Disord. 2021 Mar 18;51:102908...

Minimalism in MS: More is Less!

Our eyes are a very promising window into the brain. By looking into the eye with a technique called optical coherence tomography (OCT), we are able to visualise the retina’s ganglion cell layer that consists of naked, unmyelinated neurons. When MS’s inflammatory lightning affects the myelin sheet of the optic nerve (which is the case in 99 % of pwMS), this ultimately leads to dying back of...

COVID-19 and MS:

Having just got back from Coventry after an exforced exile for putting my mouth where silence should be. I have to be a bit more careful with what I say, as “I must not ruffle any more feathers“, Yes “I must not ruffle any more feathers”. I am on double secret probation. So I am happy to say I won’t be making certain posts on stuff that simply winds me up. Yep the...

Stuck in a loop

Starting certain MS drugs may get you stuck in a loop that you never bargained for when you started them in your early thirties or forties. The ability to stop taking drugs at an older age is something we more or less take for granted, especially if we have been disease free for ‘X’ many years. However, in the MS world things are never that simple or straightforward; there is...

The Plasma cell story – how MS begins and ends

In 1875, a famous German scientist; Wilhelm Gottfried Waldeyer Hertz, described an immune cell with a large cytoplasm (the space within the cell aside from the nucleus), he was the first to name it the “plasma cell”. We now know that this large cytoplasm hosts a production line that is solely dedicated to antibody formation (up to 10,000 molecules per second per cell). They account for less than...

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