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What Einstein forgot: Multiple Sclerosis curbs “spacetime”

We all know that time is relentless and cruel. However, do you believe it ticks at the same imperturbable pace for all of Earth’s inhabitants?  This has been a controversial topic among scientists, and one of Einsteins biggest mindboggles. Newton believed time was absolute “true time”. If the universe was to be frozen, time would tick on regardless (lockdown has taught us this is definitely...

ACTRIMS 2021 Guess what ocrelizumab depletes memory B cells and in doing so gets rid of EBV infected cells

This is a bit of a No-S-Sherlock moment. If you take anti-CD20 antibodies it depleted peripheral blood B cells out of sight. So in this study they look at the CD19 B cell subsets and conclude it depletes naive and memory B cells which express CD20. There is no suggestion that it may work because of this, but if there is no body because it has been blasted with a shot-gun you would not expect to...

BartsMS to the Excel for the Jab Please read

Heads up! To all with MS, on immunotherapies, heading to the Excel Centre in London for your 2nd jab… As soon as you arrive tell a staff member so you will get taken to the front of the line… and not have to wait for ages (like yours truly). It’s very busy there…

Thanks for the Info and advice from Rachel Horne

ACTRIMS2021. Vaccination responses after cladribine

This week is ACTRIMS2021 week and I could wait until the end of the week to give you the news but public domain, is public domain and for some people a few days will be of value, especially if you have been taking oral cladribine and you are being offered a COVID-19 vaccine, this may help you sleep abit easier. The manufacturers of CLAD “let the baton slip” in 2010/2011 when...

Barts-MS Livestream

A reminder that we are hosting the Barts-MS Question & Answer session on COVID-19 vaccines and our vaccination policy from 16h30-17h30 this afternoon. We will be live-streaming the event via YouTube. If you can’t watch the event live it will be recorded and remain available for asynchronous viewing at your leisure. As of yesterday we had received 111 questions; too many to get through...

Now you see it, Now you don’t!

Obesity or high BMI and raised cholesterol have all been linked to an increased risk of multiple sclerosis. This is of particular concern in the Western world as obesity is fast becoming the single major determinant of an individuals health quotient. But, how far should we take this in MS? In a large study of 14802 MS cases and 26703 control, a group in San Francisco set about looking for a link...

Has pharma made a mistake with BTK inhibitors? Are microglia the good guys that shouldn’t be inhibited? Don’t worry. It’s all about Balance.

I’m a fan of “you can’t have it both ways” and it means that if you say this is good for that you can’t say the opposite is good for that too. So if you have a good guy you want to augment it for it to be good, but if you get rid of the good guy you would think it is going to be be bad. When you are a mechanistic science you sometimes don’t think about the...

Whilst CD20 antibody will probably blunt your anti-COVID19 antibody response. Probably fear not as remember T cells are the important ones. #MSCOVID19

In a rush go to the bottom to read T cells are the important ones. What? Am I having a bit of psychosis? I have been on a B cell crusade and have been saying that B cells are important for MS. ut now its T cells are important. Well yes and Yes. Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K...

Rebound after treatment withdrawal says the important cells for relapse are…yep you got it!

ProfG always said the rebound that occurs after natalizumab was going to be one of the best ways to work out what are the important disease drivers in MS. Natalizumab is a brake for pathogenic cells entering the brain, Remove the brake and cells go in and trigger disease activation. Sadly by the time of thinking about this, strategies to stop rebound were developed and as we would switch...

HSCT vs. Alemtuzumab

So this is not a head to head efficacy study but says what we know alemtuzumab is associated with thyroid disease, HSCT is associated with more infections Safety of Alemtuzumab and Autologous Hematopoietic Stem Cell Transplantation Compared to Non-induction Therapies for Multiple SclerosisPeter Alping, Joachim Burman, Jan Lycke, Thomas Frisell, Fredrik PiehlNeurology Jan 2021, 10.1212/WNL...

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