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Home alone

‘Twas the night before Christmas, when all through the house, not a creature was stirring, not even a mouse ……’  The 1st of December marks, at least in my head, the beginning of the festive season and about the time the big Hollywood studios start to launch their Christmas fare.  When my daughters’ were growing-up their favourites and possibly mine, were ‘Home Alone’, followed...

Exercising during COVID19

The only habitable planet in the solar system may be imploding under the pressures of COVID-19, but it’s population on the other hand is supposedly the fittest it has ever been. It would seem more of us now have time to lift a kg weight than to place the equivalent into our stomachs. One of my MS patients even went as so far as to say that they had reduced most of their symptomatic...

Understanding cladribine. ChariotMS

As you know ProfK is a CLAD lad and we are gearing up to start ChariotMS with us going to use oral cladribine. Today I give you a link (See below) to a review on cladribine and as a COI The content has nothing to do with me. If you are considering the trial, make a cup of tea and you can read it for the next few minutes. Hope it doesn’t act as a sleeping tablet, as it is quite long. But it...

Control of Fatigue a Placebo effect?

A cross-over trial of 3 different fatigue drugs showed no difference from the fake treatment. Maybe ProfG wil comment on this, but it shows why trials are done Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue...

If you want to get rid of EBV maybe time to look at CAR-T

This is one for the hard-core scientisty types, but you ask about how to get rid of EBV. Here is a type of vaccination. You engineer T cells tonget rid of EBV. This is a mouse study but the CAR-T technology can and has been used in humans CAR-T Cells Targeting Epstein-Barr Virus gp350 Validated in a Humanized Mouse Model of EBV Infection and Lymphoproliferative Disease.Slabik C, Kalbarczyk M...

Not being treated is a risk factor for secondary progressive MS

Transition to secondary progression in relapsing-onset multiple sclerosis: Definitions and risk factors.Iaffaldano P, Lucisano G, Patti F, Brescia Morra V, De Luca G, Lugaresi A, Zaffaroni M, Inglese M, Salemi G, Cocco E, Conte A, Ferraro D, Galgani S, Bergamaschi R, Pozzilli C, Salvetti M, Lus G, Rovaris M, Maniscalco GT, Logullo FO, Paolicelli D, Achille M, Marrazzo G, Lovato V, Comi...

Moving the goalposts

Barts-MS rose-tinted-odometer: ★★★★★ About 5 or 6 years ago, when we decided to replace the term DAF (disease-activity free) with NEDA (no evident disease activity) as a treatment target MS we created space to allow us to ‘move the goalposts’, i.e. to let our treatment targets in MS evolve as new insights and new technologies emerged.  This is particularly pertinent as the field now realises that...

Carpe diem

Barts-MS rose-tinted-odometer: ★★★★★ I love science; it is such a thrill. I think science historians will look back at 2020 and the impact COVID-19 has had on science and scientific publishing and will define a new scientific era as being AC19 (after COVID-19) and the other era as BC19 (before COVID-19). The reason why I say this is because some of the changes that COVID-19 has induced in the...

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