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Trials going classical

One of the next new kids on the block is going to be Ofatumumab (Anti-CD20). There were positive data on the MRI scans and on relapse rate that puts it in the league of the big hitters. This is hardly surprsing as it is a Me-Too drug and does the same as rituximab and ocrelizumab. This data was shown at Ectrims2019 in the ASSCLEPIOS (Greek god of healing) trials. OPERA was the trial name for...

Hot Topic the Video Battle of the B cells

The anti CD20 debate You asked about the slides of ProfB and said you don’t get the nuiance of them. Well in this case, we can help. There were 3 sessions that were live streamed, MD2 was watching. I haven’t seen it yet but will be cringey no doubt, but ProfB had a 15minute slot and got through the slides in about 11-12 minutes. So have a watch and see if you thoughts match what was...

ECTRIM2019

Due to a mess-up this morning at ECTRIMS the presentations disappeared meaning that ProfB and DrK had to do their presentations without any slides.

Baker ectrims teaching slides from BartsMSBlog

The MODs are replicating, ozanimod is on the way

Fingolimod was the first Sphingosine-1-phophate receptor to be approved, then there was Siponimod and we have a load more to arrive. Here is the data for ozanimod. The efficacy looads in the small ball part of that seen with cladribine and alemtuzumab. If is an S1P1 and S1P5 modulator and so like Siponimod. It does not seem to have the heart issues which are inpart caused by S1P3 which fingolimod...

ECTRIMS 2019: Biomarkers

ECTRIMS, Stockholm Biomarkers session Finally in the ECTRIMS mood! Hundred Unbelievable that an year has passed already since the last one, but before I get maudlin, lets get some focus back in. I’ll be co-chairing a session this Friday with Dr Salzer, from Umea University, Sweden (Rituximab man). You can see all the topics of discussion in the program above, but for those of you who...

How quickly and how does ocrelizumab work? Is it “Tesco” science?

This study examines the speed at which CD20 B cell depletion works. The answer is for MRI it is a month and for clinical it is within 2 months. Why is this interesting? This is because it informs on switching. If you take my favourite drug…you know the one :-(, yes the one that works by every mechanism under the sun and is the Worlds best seller and someone says it takes 9 months to work...

Remyelinating agent. Is this the antidote to shrinking lips

A modified flavonoid accelerates oligodendrocyte maturation and functional remyelination.Su W, Matsumoto S, Banine F, Srivastava T, Dean J, Foster S, Pham P, Hammond B, Peters A, Girish KS, Rangappa KS, Basappa, Jose J, Hennebold JD, Murphy MJ, Bennett-Toomey J, Back SA, Sherman LS. Glia. 2019 Sep 6. doi: 10.1002/glia.23715. [Epub ahead of print] Myelination delay and remyelination failure...

Next week is ECTRIMS 2019, Will ProfB get In or Back?

Back of the T shirt Although nothing to do with MS, recently ProfB was in the News for a different reason…not Drug Discovery but probably suspected drug pushing. Will he get pulled over again, especially as the story has left these shores . If he gets into Sweden ProfB is giving a live talk on thursday morning . I guess live streamed from the ECTRIMS web site on the “Rationale of B...

ECTRIMS2019. ProfB’s hunch is playing out

Snooze and You Loose….I am sorry to say this is not our work…we were too slow, but you had the idea here first folks. We (and others to be fair) have made the idea that memory B cells are an important tartget. If true it says something about CD20-depletion. CD20 antibodies are dosed every 6 months because this is how long it takes for the CD19 B cell population to return. However...

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