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Gut time

Why don’t I bother reporting microbiome studies as the next great cure and why not report all the supportive (scientifically interesting) animal studies which give us “Cure of the week”. Simple…the data seems to be something that is produced via the intestine and the effects are simply not good or consistent enough….for it to be ready for prime time. This week...

#MSCOVID19 Flu Jab

It seems that there have been fewer cases of Flu in Australia this Winter, possibly because people have been socially distancing. I am on the waiting list for this years flu jab and am not going to get an offer until the Heath Care professionals and others have been offered their Jab. Are you an anti-Jaxer but want to avoid COVID-19. But maybe vaccination against Flu can reduce your risk f COVID...

Will a sugar diet sort out progressive MS.

This week media stories have surfaced that a diet of plant sugar will deal with progressive MS because it rejuvenates the microglia to clear nerve debris away to promote recovery. Great we say. This study identifies a trigger factor called ATG7 . The Autophagy related 7 protein acts as an essential protein for cell degradation and its recycling. But we know this already based on loads of studies...

COVID Breakfast…MS research diverted elsewhere

COVID-19 has diverted resources away from MS research and it has diverted people away from MS research….Who knows what the consequences will be. Many people could not get in labs unless they did COVID work, and some weren’t allowed in until they had got grants to do COVID work, others were allowed to spend their grants on covid work. Some people worked on COVID so they could do their...

Virtual MS clinics: The perks of being a digital nomad!

Neurology clinics anno 2020. Source: As you might have experienced yourself when contacting your GP or consultant, the only tide that unfortunately has been turned so far is the NHS going fully digital. This means that I and all other Bart-MS consultants have been relying heavily – as in 99% of our clinic encounters – on virtual clinics to reach out to our MS patients since March 2020...

#MSCOViD19 Vaccine readiness

Its not the level of depletion, its the duration and persistent B cell depletion that is an issue Normal antibody response after COVID-19 during treatment with cladribine.Celius EG.Mult Scler Relat Disord. 2020;46:102476. doi: 10.1016/j.msard.2020.102476. Online ahead of print.PMID: 32882501 Fernández-Díaz E, Gracia-Gil J, García-García JG, Palao M, Romero-Sánchez CM, Segura T. COVID-19 and...

Withdrawn…Why?

Retraction of Publication Rev Neurol (Paris). 2020 Sep 15;S0035-3787(20)30660-3. doi: 10.1016/j.neurol.2020.08.001. Online ahead of print. WITHDRAWN: Incidence and mortality of COVID-19 in Iranian multiple sclerosis patients treated with disease-modifying therapies DOI: 10.1016/j.neurol.2020.08.001 The most damming report of anti-CD20 risk of MS has been withdrawn by the...

Faster ocrelizumab infusions appear to be safe

Vollmer TL, Cohen JA, Alvarez E, Nair KV, Boster A, Katz J, Pardo G, Pei J, Raut P, Merchant S, MacLean E, Pradhan A, Moss B. Safety results of administering ocrelizumab per a shorter infusion protocol in patients with primary progressive and relapsing multiple sclerosis. Mult Scler Relat Disord. 2020 Aug 18;46:102454. COVID-19 has focused attention to the amount of time people are kept in the...

Having sight but no vision

The blurring of vision in MS is synonymous with optic neuritis in most instances, however visual defects also occur secondary to lesions in the brain proper. These are often silent or misconstrued as the former. Below is a pictorial representation of potential field defects based on the area of lesion location within the visual pathways of the brain: Little is known of the evolution of these...

Will the mechanistic SH1 ever stick? or will we have more failed MS studies?

Today is hard core science day. We can learn a bit together. You can learn a lot for the human experiment, which is the clinical trial. Success of trial points the finger at something important, but failure can too. We thought what works in arthritis (MS of the Joint) would work in MS (arthritis of the brain). That was until we tried tumour necrosis factor (TNF) inhibitory activity. It is...

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