CategoryArchive

Animal Studies need to pull their socks up and be more transparent!

If people are working with animals, especially those of a severe nature, then is it time to change! In this report we suggest that what people are calling progressive EAE is nothing more that relapsing-remitting EAE that is ascychronous with increasing poor recovery. This is important because we know that relapsing EAE responds to T cell therapy but we want alternative treatements for progressive...

Memory B cells during Symptoms.

This study looks in the blood when someone gets a hearing problem..They find mature naive B cells. Are these the problem. Where are the memory B cells they aren’t there..Maybe they have moved out of the blood to cause the problem. Lymphocytes B population profile in a case of multiple sclerosis presenting with sudden sensorineural hearing loss caused by a demyelinating pontine...

Aaron Boster is Ace

I’m part of the Aaron Boster fanclub. He is an American neurologist who inhabits the social media space. In this video he asks questions of the old school (dinosaur) and new school neurologist……. Love it and he has three shirts… although two sound like the same one:-) Sadly there are plenty of the “old school” neurologists about. They should carry a health...

Thyroid disease with Alemtuzumab – risk mitigation

There is a popular old saying in English – “forewarned is forearmed”. Prior knowledge that something is going to happen offers tactical advantage, whether you’re at war or simply everyday life. The difficulty, however, is that more often than not we are transfixed by the detail of the matter, resulting in numerous avenues of investigation in the process, some of which are...

Converting to SPMS, worse thing is uncontrolloed worsening

Risk of secondary progressive multiple sclerosis: A longitudinal study.Fambiatos A et al. Mult Scler. 2019 Aug 9:1352458519868990 BACKGROUND:The risk factors for conversion from relapsing-remitting to secondary progressive multiple sclerosis remain highly contested. OBJECTIVE: The aim of this study was to determine the demographic, clinical and paraclinical features that influence the risk of...

Education Doube negative memory

In humans B cells can be recognised by the expression of CD19 (a molecule involved in B cell antigen receptor signalling and B cell diferentiation into different B cell sub-types). Memory B cells are recognised by the presence of a marker called CD27 (as survival factor receptor and activation marker also found on activated T cells) and Immunoglobulin (antibody) arrangements. Antibodies serve are...

Looking in the blood or brain for inflammatory markers

NDG may have something to say about this one. In this study they looked for inflammatory markers in the blood and spinal fluid in people with MS. I have removed the bits about predictors as those familiar with the blog, know that these are generally never good enough to say anythng about the individuals. The point I want to make is this, that you may been to be prepared to have a lumbar puncture...

Mortui vivos docent

We haven’t done this in a while but the post from the Cleveland Clinic, reminds me to remind you to consider donation of your tissues You can watch a video here To Registered please visit here MS Society Tissue Bank If you live in the States read this Comprehensive Autopsy Program for Individuals with Multiple Sclerosis.Dutta R, Mahajan KR, Nakamura K, Ontaneda D, Chen J, Volsko C...

Life on Mars, Suppressor T cells are Back

For those of you not old enough to remember “Life on Mars”….yes it was a TV programme about a Cop who travelled back in time to the 1970s..sexism, bad haircuts, those platform shoes and hideous clothes and all that stuff ….with flash backs to a TV cop show called the Sweeney (The flying squad), who would go after armed robbers and yes it is a David Bowie song from the...

Cannabis and Gut Bacteria. The Answer or more animal nonsense?

Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome. Al-Ghezi ZZ, Busbee PB, Alghetaa H, Nagarkatti PS, Nagarkatti M. Brain Behav Immun. 2019 pii: S0889-1591(19)30647-6. doi: 10.1016/j.bbi.2019.07.028. [Epub ahead of print] There you have it cannabis works because it...

Translate

Categories

Recent Posts

Recent Comments

Archives