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I’m a vegan can I have antibody treatment?

This is up to you. it’s your choice. The important question is how do you make an antibody? I have to say all of them have their historical and technological origins in a furry beasty, notable mice and rats. You said “ I read that ocrelizumab was made from Chinese hamster ovary cells…. Is my ocrelizumab harvested inside a hamster?” Is the Hamster straining to push-out...

Science Fiction: Vitamin D

Failed vitamin D trial..Failed to infrom:-( ProfG has done a post on medical fiction. It is perhaps approriate to do a post on science fiction. As you know scientists are like sheep and they herd together and follow one and other. They stick close to the “dogma machine” and follow trends because, this is where money gets put. I have gone on the record of discussing a few. Some I have...

Astrocyte targets

The expression of MAFG in mice is high compared to human (Data from public data bases MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ.Nature. 2020 Feb 12...

Alemtuzumab.The irony of Humanisation. Part V

What have we been doing. So over the past week has been building up the story of alemtuzumab, the Worlds first Humanized antibody. However, it is the worst when it comes to anti-drug antibody responses. The paper today argues perhaps why. So if you are taking alemtuzumab it is a must-read. So you can sit down in you arm chair and have a good read. The paper is now online so click here , download...

shoes for foot drop

Pilot Study of Cadence, a Novel Shoe for Patients with Foot Drop.Evora A, Sloan E, Castellino S, Hawkes EW, Susko T. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:5291-5296 Foot Drop is a mobility disorder that limits ankle dorsiflexion, complicating the swing phase of gait and balance. It is a common result of a neurological injury or disease such as stroke, cerebral palsy or multiple sclerosis...

Why is DrAngry angry? Cos some people are getting futile antibody treatments. Today it’s Rituxumab and futile is not the only issue..Danger is another!

I know that you hate mysteries and some people have been asking “Who is DrAngry?”. In short our antibody guru and go to guy for technological ideas. To help you guess, here is a clue from Basil Brush. Never seen Basil? Click here. Helps if you are over 45 Boom Boom Antibodies can stop working because they cause anti-drug antibody (ADA) responses. Alemtuzumab is particularly adept at...

Lovey moment. The Science microcosm

Don’t you just love it when you hear critics arguing over the meaning of a painting. Does this picture say something about the state of science. Two little mice (Basic scientists) fighting over scraps (cash) when the mouse food (grants) store is elsewhere in another station. A fight over this cell or that cell (idea) in the hope they win and eat. Will it then give them the right microbiome...

Inflammation in CNS is associated with activity

Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS. Engel S, Friedrich M, Muthuraman M, Steffen F, Poplawski A, Groppa S, Bittner S, Zipp F, Luessi F. Neurol Neuroimmunol Neuroinflamm. 2019;6(5). OBJECTIVE: We explored the incremental value of adding multiple disease activity biomarkers in CSF and serum for distinguishing MRI-based benign...

EBV two pathways to risk

High Levels of Epstein-Barr Virus Nuclear Antigen-1-Specific Antibodies and Infectious Mononucleosis Act Both Independently and Synergistically to Increase Multiple Sclerosis Risk. Hedström AK, Huang J, Michel A, Butt J, Brenner N, Hillert J, Waterboer T, Kockum I, Olsson T, Alfredsson L.Front Neurol. 2020 Jan 24;10:1368. doi: 10.3389/fneur.2019.01368. eCollection 2019 So here we have additional...

Who is DrAngry?

When the MDs appeared, we got the same question I have been showing pictures of DrAngry and whilst you may think DrA looks abit like an Angry bird, here is DrAngry on the KangMobile, also known as the Lemon D….after a 100 mile Charity bike ride….Yep we are all bonkers at TeamG and Chums. Can see this is a good likeness,? Look at those pins. Does he use Imac? This is what ProfG will be...

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