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Is fingolimod safe in pregnancy?

Safety of Disease Modifying Treatments (DMTs) whilst pregnant and breastfeeding (from Practical Neurology journal) The risk-mitigation strategies surrounding DMTs in pregnancy haven’t come that far over the last two decades. So far, we have abstain from pregnancy, stop treatment prior to pregnancy, stop if you discover that you’re pregnant, or switch to Copaxone during pregnancy...

Faecal transplant goes horribly wrong

This is one from ProfGs twitter feed. As you know I am a big fan of the value of microbiota 🙂 and the hundreds of trials of faecal transplant aiming to treat MS and every other condition. But be warned, if the Poop isn’t from a reputable source, things may not go the way you think. This Poop Transplant Resulted In A Death, FDA Warning via @forbes When you put someone else’s poop in...

Menopause and MS

Impact of natural menopause on multiple sclerosis: a multicentre study. Baroncini D, Annovazzi PO, De Rossi N, Mallucci G, Torri Clerici V, Tonietti S, Mantero V, FerrĂČ MT, Messina MJ, Barcella V, La Mantia L, Ronzoni M, BarrilĂ  C, Clerici R, Susani EL, Fusco ML, Chiveri L, Abate L, Ferraro O, Capra R, Colombo E, Confalonieri P, Zaffaroni M. J Neurol Neurosurg Psychiatry. 2019. pii: jnnp-2019...

Street Light Science in EAE…

What’s Street light science? Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple Sclerosis. Hamilton AM, Forkert ND, Yang R, Wu Y, Rogers JA, Yong VW, Dunn JF. Sci Rep. 2019; 9(1):8488. doi: 10.1038/s41598-019-44682-6 Atrophy has become a clinically relevant marker of progressive neurodegeneration in multiple...

Scotland-MS Central

BACKGROUND: Fifteen regional studies published over the last six decades surveying prevalence, mortality and hospital admissions have suggested that Scotland is amongst the highest risk nations for multiple sclerosis (MS) in the world. However, substantial intranational variation in rates (between regions) has been described in numerous countries, including in the only previous Scottish...

MS Frontiers

Every alternate year we have the MS Frontiers sandwiched between MS Life organized by the Multiple Sclerosis Society. MS Frontiers is for HealthCare Professionals and MS Life is for people with MS. The 3 Ps of MS Frontiers 2019 As an early career researcher or health care professional, few things are more enriching than the chance to meet leaders in the field, to learn from them, be inspired by...

Multiple Sclerosis Research

A comment on the Multiple Sclerosis Research Blog In a world where it is easier to be lost than discovered, dissonance is the word of the day. When you have a serious medical condition, your day to day life is suddenly uncertain and unpredictable, your mood, a narrative from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition – DSM-5 for short, and its 186 footnotes...

Teriflunomide long-term effects…You can’t have it both ways

Characterizing lymphocyte counts and infection rates with long-term teriflunomide treatment: Pooled analysis of clinical trials. Comi G, Miller AE, Benamor M, Truffinet P, Poole EM, Freedman MS. Mult Scler. 2019 Jun 7:1352458519851981. doi: 10.1177/1352458519851981. [Epub ahead of print] BACKGROUND:In Phase 3 studies, teriflunomide reduced relapse rates and disability progression compared with...

MS and Electric Devices

Relationship between the use of electronic devices and susceptibility to multiple sclerosis. Khaki-Khatibi F, Nourazarian A, Ahmadi F, Farhoudi M, Savadi-Oskouei D, Pourostadi M, Asgharzadeh M. Cogn Neurodyn. 2019 Jun;13(3):287-292 Multiple sclerosis (MS) is an autoimmune condition influenced by both genetic and environmental factors. Dirty electricity generated by electronic equipment is...

Pregnancy and MS

Pregnancy and Family Planning in Multiple Sclerosis. Langer-Gould AM.Continuum (Minneap Minn). 2019 Jun;25(3):773-792 PURPOSE OF REVIEW: This article provides practical guidance on successful management of women with multiple sclerosis (MS) through pregnancy and the postpartum period. RECENT FINDINGS: Recent studies indicate that most women diagnosed with MS today can have children, breast-feed...

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