CategoryArchive

Please put me out of my misery

Har profG rätt? Han säger att hämningen av hjärnatrofi är värre med CD20-utarmande antikroppar. Visa och publicera dina hjärnatrofi-data under åren 2-3 efter initial rituximab-behandling från sjukdomens början

آیا profG درست است؟ او می گوید مهار آتروفی مغز با آنتی بادی های تخلیه CD20 بدتر است. داده های آتروفی مغز خود را طی 2-3 سال بعد از درمان اولیه ریتوکسیماب از ابتدای بیماری مشاهده و منتشر کنید

Memory B cells as a central target for relapsing MS. How much more evidence do you need?

reduction of relapses after rituximab treatment A few days ago we had the the effect of ozanimod on lymphocyte subsets and whilst T cells subsets were examined, B cells subsets were not…I said how can you understand how ozanimod works if you do not look at memory B cells. Sadly this view falls on deaf ears or is that blinkered eyes We made the point that all agents that inhibit MS also...

Getting rid of autoimmunity caused by alemtzumab

Alemtuzumab is one of the most effective disease modifying treatments, but the major problem associated with it’s use is the development of secondary autoimmunities. What is the problem? One suggestion was that it depends on how T cells repopulate from the thymus.However, we suggested that it could be due to uncontrolled B cell hyper-proliferation in the relative absence of T cell...

Walk beside me…just be my friend

“Don’t walk in front of me… I may not followDon’t walk behind me… I may not leadWalk beside me… just be my friend”― Albert Camus Since lock-down or ‘knock-down’ as I like to call it, I’ve succumbed to the reading club. I have just completed the reading of ‘Motion of the body through space’ by Lionel Shriver, which in my haloed opinion is the most depressive book that...

Rocky Mountain Ritixumab Fever

This is the real life experience of a single centre in the USA. As you can see their experience with CD20 depletion was essentailly as good or better to other commercial products, Rituximab versus natalizumab, fingolimod, and dimethyl fumarate in multiple sclerosis treatment.Vollmer BL, Nair K, Sillau S, Corboy JR, Vollmer T, Alvarez E.Ann Clin Transl Neurol. 2020 Aug 6. doi: 10.1002/acn3.51111...

Best Neuroprotection is to stop inflammation from occurring.

We hear about the “real MS” as so terms as if it is un-treatable….but if we want to stop nerve damage, we have to deal with the inflammarory reaction as quickly and as effectively as possible. Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years.Pulido-Valdeolivas I, Andorrà M, Gómez-Andrés D...

#MSCOVID19. Time for business?

COVID-19 and high-efficacy multiple sclerosis therapies: Time for business as usual?Brownlee WJ.Mult Scler. 2020 Aug 7:1352458520948211. doi: 10.1177/1352458520948211. “In the vast majority of people with MS, COVID-19 produces a mild illness. Preliminary data suggest that older age, comorbidities and more advanced physical disability are more strongly associated with poor outcomes in people...

Lithium

Animal studies suggest efficacy of lithium. This study in ms suggests lithium is tolerated and that it doesn’t work. So maybe the end of lithium. But the trial is too small to do efficacy so it was probably doomed before it started. People now see failure will a bigger trial be funded. I doubt it Background: Disability accumulation in progressive multiple sclerosis (MS) results from...

How does BTK inhibitor works

I thought interesting, BTK as the new kid on the block should inhibit B cell activity and it should inhibit memory B cell activity. I saw the title and thought interesting and then saw the contents and its mouse EAE and at this point I sort of switched off. Because mice have different B cells and importantly it is a hard core T cell mediated disease in mice. Indeed it was shown by the company...

I must have Wind as it seems I keep repeating myself

Todays B cell burp was reported as it came out of the Horse’s mouth when it came out at ECTRIMS2019, so I am not going to dwell on the take home message that it was positive and inhibited relapsing MS. This was an interesting trial design that recruitment was continued until set points were reached to ensure the trial delivered an answer. “Ofatumumab was associated with lower...

Translate

Categories

Recent Posts

Recent Comments

Archives