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#MSCOVID19….It’s T time

Whilst you may think of me as a B cell maniac, when it comes to COVID-19, I have made the case that B cells are not at the head of the immune cell pack We have made the case that MS treaments get rid of memory B cells for a long time. In contrast, after depletion, the cells that come back quickly are the B cells. It is the naive B cells that will make cells that make antibody to new infections...

Live Webinar Tonight 6PM ET! MS and COVID-19: A Webinar Series for Healthcare Providers

Join the National MS Society and the Consortium of MS Centers for a live webinar featuring Gavin Giovannoni, MBBCh, PhD, Chair of Neurology, Blizard Institute Barts and The London School of Medicine and Dentistry and Aaron Miller, MD , Medical Director, Corinne Goldsmith Dickinson Center for Multiple Sclerosis. This webinar will focus on disease modifying therapies and clinical decision-making in...

Do you smoke cannabis?

The findings from this study may interest some of our readers. Cannabis use in MS is licensed for spasticity management and to a lesser extent proven to be helpful with refractory neuropathic pain. Some also use cannabis to manage the psychological downsides of MS. Given it’s increasingly popularity since legalisation, the authors set out to determine whether discontinuing cannabis worsened...

Are we over dosing with anti-CD20? Evidence based on rituximab

People with stable MS who were treated with rituximab and then watched remained stable. This should come as nothing new for the general reader but in case you are new to the blog read on Maarouf A, Rico A, Boutiere C, et al. Extending rituximab dosing intervals in patients with MS during the COVID-19 pandemic and beyond?. Neurol Neuroimmunol Neuroinflamm. 2020;7(5):e825. Published 2020 Jun 25...

What happens with cladribine in the long-term

Abstract Long-term effectiveness in patients previously treated with cladribine tablets: a real-world analysis of the Italian multiple sclerosis registry (CLARINET-MS).Patti F, Visconti A, Capacchione A, Roy S, Trojano M; CLARINET-MS Study Group.Ther Adv Neurol Disord. 2020 Jun 10;13:1756286420922685 Background: The CLARINET-MS study assessed the long-term effectiveness of...

#MSCOVID19 French Registry Reports

The french registry has delivered their first taste of the COVID-19 pot and they support our suggestions that DMT are not creating mega problems if you get infected with SARS-CoV-2. The risk factors are age (co-morbidities increase with age), obesity (co-morbidities increase) and disablity (co-morbidities increase with disability). Interestingly, DMTs were associated with lower risks of severe...

What’s a Blood Spot test

When you are born you had a prick in your heel and you put the blood spot on a card called a Guthrie card. You let the card dry and then you can stick the card in the post. In terms of coronavirus, it will be dead in a couple of days max and it is not going to escape the enveloped to infect the postie A blood spot is about 50-75 microlitres in volume. When the spot is dry the contents are...

NICE not so NICE again

Siponimod is not recommended, within its marketing authorisation, for treating secondary progressive multiple sclerosis with evidence of active disease (that is, relapses or imaging features of inflammatory activity) in adults. Interferon beta-1b is currently the only disease-modifying treatment available for people with active secondary progressive MS. However, NICE says that few people take it...

Alemtuzumab exposes lots of interesting biology. #MSCOVID19 The macrophage is important for getting rid of SARS-CoV-2

Yesterday we (MD1&MD2) and others (MS researchers) were accused of being responsible for the downfall of alemtuzumab with the regulators. This is because they (other MS researchers) have drip-fed reported adverse events like these: Immune-mediated hepatitis induced by therapy with alemtuzumab in a patient with Multiple Sclerosis. Bolte FJ, Schmidt HH, Schlevogt B.Hepatology. 2020...

Providing Energy to Nerves Saves them from Damage

Read Licht‑Mayer et al. The brain is very energetically active and consumes a large amount of energy. This energy is made in small organelles inside the cells called mitochondria. There adenosine triphosphate ATP, which is a unit of cellular energy, is made. During demyelination the mitochondrial move to areas where myelin is lost as it takes alot of energy to keep the nerve firing. If they...

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