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Off-Label Use of Drugs

I give you something that is not MS COVID (p.s. thats below). Laurson-Doube J, Rijke N, Helme A, Baneke P, Banwell B, Viswanathan S, Hemmer B, Yamout B. Ethical use of off-label disease-modifying therapies for multiple sclerosis. Mult Scler. 2021 Jul 26:13524585211030207. doi: 10.1177/13524585211030207. Epub ahead of print. PMID: 34304636 Background: Off-label disease-modifying therapies...

SIZOMUS randomized clinical trial is on the roll

SIZOMUS anti-plasma cell RCT I’m happy to notify that SIZOMUS (Safety of IxaZOmib targeting plasma cells in Multiple Sclerosis) is re-commencing after MHRA approval. This follows a pre-planned interim safety analysis. MHRA stands for Medicines & Healthcare products Regulatory Agency and without their say so this trial would not have been able to proceed. The Medicines and...

#MSCOVID19

Sormani, MP et al. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context. SSRN:  Background: It is unclear how multiple sclerosis (MS) affects the severity of Covid-19. Methods: Hospitalization, Intensive Care Unit (ICU) admission and death after Covid-19 diagnosis of 1362 MS patients were compared to the age and sex-matched Italian population in a retrospective...

Vaccine Safety in MS

The safety issues for MS are similar to the the issues of the general population but one issue to be aware of is Uhthoffs phenomenenon. This is where an increase in temperature can cause demyelinated nerves to transiently stop firing. One of the side effects of vaccines can be fever and so this will raise temperature and so could cause some symptoms to transiently worsen. However, I am sure you...

The deluge appearing #MSCOVID19 More evidence for CD8 T cell response in people treated with anti-CD20

Drip Drip Drip its coming as the rain arrives so are those B cell papers I recently saw a colleague who was concerned about whether it was OK to cite a pre-print because it was not peer-reviewed….However this is the new norm and in reality you can review it yourself. Also some reviewed papers are not without issues. You have to determine whether you want to live under a “knowledge...

Home care..Natalizumab style

During the pandemic, avoiding hospitals has been advantageous. Natalizumab is usualy infused in hospital. In this study they looked at infusing at home and they concluded it was safe and cheaper to infuse at home. However, I would start to ask why bother? Subcutaneous natalizumab has been approved and whilst this will be intially administered in the hosptial environment…I can easily see...

Die Wende: Extending the anti-CD20 overdose

It’s a bittersweet fact that wars spark big leaps in science, and this has unfortunately also been true for our fight against the COVID-19 pandemic. When it comes to treating MS, susceptibility to common infections and ability to mount vaccine responses have become important themes among neurologists. Furthermore, pwMS prefer drugs that do not require regular hospital or phlebotomist visits. One...

Antibodies don’t hang around for ever, lets hope the COVID-19 virus doesn’t either

Whilst we are on about antibody responses, this is a study from UK where people got pfizer or astrazeneca vaccine at about 10-11 week intervals and it was evident that antibody levels dropped overtime, so after “Frazer day” (OK abit amateur dramtics) on monday when we were all let loose to spread virus at will. Frazer from Dads Army Remember that the level of protection could drop a...

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