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Sod the #MSCOVID19 vaccine give me the MS trials

You can have loads of ideas but you can’t do all the science on the planet, but it is nice to see an idea come true. Since the COVID-19 pandemic arrived Now what do I mean Sod the COVID vaccine, well of course I dont mean don’t take it if you are offered it. But what is the vaccine going to do? Hopefully, it is going to stop you getting symptomaic infected so that you do not pass on...

SDMT

Is the Symbol Digit Modalities Test a useful outcome in secondary progressive multiple sclerosis? Koch MW, Mostert J, Repovic P, Bowen JD, Uitdehaag B, Cutter G. Eur J Neurol. 2021 Jan 15. doi: 10.1111/ene.14732. Online ahead of print Background: It is unclear which cognitive outcome measure is the most useful for clinical trials in multiple sclerosis. To investigate the usefulness of the...

Central Vein for MS diagnosis

Mention veins and I geta shiver down my spine with the thought of CCSVI and blocked veins However, I heard about central veins from my ex-roomy ProfK. Ex…..cos I have been kicked out due to COVID-19, will I ever get back in? He told me about FLAIR* pronounced flare-snowflake, I mean flare-star. This is a combined magnetic resosoance contrast technique for visualizing White Matter Lesions...

Monkey MS

A few years ago it was found that some monkeys in Portland, USA developed a demyelinating disease that looked abit like MS. The found out that it was caused by a herpes virus abit like EBV. Now they ask is there autoimmunity to myelin and the answer appears to be Yes. Myelin-specific T cells in animals with Japanese macaque encephalomyelitis.Govindan AN, Fitzpatrick KS, Manoharan M, Tagge I...

Cladribine switch

Sorry this post was launched before I had even written it. So the idea that memory B cells may be important is getting some traction with some people but for others they don’t care. However, if people start to study these ideas them information surfaces and you then have to ask is the idea wrong. In this study they say cladribine gets rid of memory B cells if it is working and them also say...

Polypharmacy in MS

In this blog, our overarching goal has been to keep our readers up to date with the latest research in MS. One of the things I’ve noted in this time is that the vast wealth information out there isn’t insurmountable – you only need to select the ones that appeal to you, or are relevant to your practice. Information/’knowledge’ is probably the last bastion of...

Secondary progression conversion is low after alemtuzumab

This is a paper that may be of interest to people who have taken alemtuzumab in the past few years. It looks at the conversion rate to SPMS. Sadly I think an error has been made from relegating alemtuzmab from being the the easiest drug to prescribe first line to being a drug that has been thrown on the maggot-pile by the regulators to be essentially third line. The risk is yours not theirs...

BartsMS COVID-19 vaccine advice – update

The advice I posted on 29 Dec is already outdated. Meantime NHS England decided to introduce the 3 month gap between 1st & 2nd dose of any of the vaccines currently available in the West, and only a couple of days ago did the latest mRNA vaccine (Moderna) receive the green light from the MHRA. We have therefore updated our advice – here it is: COVID-vaccines-DMT-BartsMS...

RNA vaccines the saviour…but the first iteration may not be good enough for prime time

It seems the makers of the COVID vaccine have turned their hand to stopping MS and on the back of the success with covid what will stop them and their partners. Tron. However like the film the current view is probably fanasty… but maybe it is a way of making protein that could be used for an MS vaccine. It does not appear to boost the immune response..so a new way to make Glatirimer acetate...

A marker for active MS points at B cells

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis.DiSano KD, Gilli F, Pachner AR.Mult Scler J Exp Transl Clin. 2020 Dec 16;6(4):2055217320981396.  Background: Clinicians caring for patients with Multiple Sclerosis (MS) need improved biomarkers to aid them in disease management. Objective: We assessed the predictive value of the candidate biomarker...

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