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B cell depleting Milk

Pregnacy is an important issue. At present few MS treatments are available for use in pregnacy. If you are taking ocrelizumab you have to wait for 6 months in the USA and 12months in the EU before you try to concieve. Why?. This is because the antibody hangs around for a long time. An So if you get an infusion of 600mg of ocrelizumab, which equates to about 600mg in 5 litres of blood so...

Guest Post…Do No Harm

Primum non nocere A guest post from Dr James Stankiewicz, Boston. One of the fundamental tenants of medicine is “Primum non nocere”—First, Do No Harm. In theory this sounds quite easy to accomplish. And at times it can be. A surgeon should not, for example, amputate the left foot when the right foot is problematic one. But at other times it can become quite complicated to know what to do when...

Adenovirus infection after HSCT

Adenovirus is pretty common in the general population, responsible for the common cold, sore throat, bronchitis, diarrhea and conjunctivitis. It is harmless in most instances and like the herpes virus, most of us remain latently infected. During periods of immunosupression, however, the adenovirus can reactivate causing untoward trouble. The latter can range anywhere from organ-specific...

Risk factors for reactivation of clinical disease activity in multiple sclerosis after stopping natalizumab

You can all read the text, natalizumab seems to hold everything in check Risk factors for reactivation of clinical disease activity in multiple sclerosis after natalizumab cessation. Mustonen T BM, Rauma I MD, Hartikainen P MD, PhD, Krüger J MD, PhD, Niiranen M MD, Selander T M.Sc, Simula S MD, PhD, Anne M R MD, PhD, Kuusisto H MD, PhD. Mult Scler Relat Disord. 2019 Nov 5;38:101498...

Another mechanism of damage involving microglia

If a nerve cannot talk to another nerve, problems may occur. Loss of myelin will slow nerve transmission but if there is no synapse (the point where one nerve contacts another nerve) there is no nerve signal transmission. In this study they look at the visual system and they find that synapses are lost, even if there is seemingly no demyelination, They showed that microglia are removing the...

Interferon Beta does not influence Birth weights

The association between exposure to interferon-beta during pregnancy and birth measurements in offspring of women with multiple sclerosis. Burkill S, Vattulainen P, Geissbuehler Y, Sabido Espin M, Popescu C, Suzart-Woischnik K, Hillert J, Artama M, Verkkoniemi-Ahola A, Myhr KM, Cnattingius S, Korhonen P, Montgomery S, Bahmanyar S. PLoS One. 2019; 14(12):e0227120 BACKGROUND: Interferon-beta (IFN...

Understanding MS

If you want to get a view of MS from someone else this is an online review. I am not sure I completly agree with the view point but it is good to get different view points. They argue that MS is a primary degenerative disease (The real MS) and is accompanied by varying degrees of inflammation. Sadly the “Inside-out” (trigger from inside CNS causing cells to enter) and “outside...

HSCT gets rid of T cells

This is open access so for those interested, you can have a read. It says efficacy of HSCT is associated with lost of T cells from the CNS. I guess we could have guessed that this would happen, and one would suspect it should happen with any treatment that works. The study also serves to show that most people don’t give a monkey’s about B cells. Mention only T cells and there is no...

Is aging the problem to the woes of animal experimentation and lack of clinical translation?

There has been a failure to translate ides from animals into human benefit. EAEers either do not care about this, which is one central problem, or sometimes people scratch their heads and try and come up with reasons for this failure. In this study it is suggested that aging is not accomodated in the thought process. This is totally accepted and indeed an aged mouse for example does not handle an...

Dr Ruth. Reports of her Studies

Dr.Ruth hasn’t got the log-in details of the new blog, so she asked me to post this. Dr.Ruth says As some of you may know one of the projects that we have been working on has been a vitamin D study in collaboration with the UK MS Register, called the ‘Vitamin D in people with MS’ study. We want to thank all of the participants who took part in this – those who filled out questionnaires, or...

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