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#MSCOVID19 Astrazeneca Vaccine and Blood Clot information

Here are some links to information about the Astrazeneca vaccine and small risk of blood clotting, which have just gone live. Hopefully these will help with your questions. Press release MHRA issues new advice, concluding a possible link between COVID-19 Vaccine AstraZeneca and extremely rare, unlikely to occur blood clots – GOV.UKThe benefits of vaccination continue to outweigh any risks...

“Only your eyes can show the suffering” dixit Fausto Coppi

Once upon a time, there were cyclists as Fausto Coppi. He was the kind of guy that attacked 5 km after the start of the race (Milan San-Remo 1946), and then dropped the rest of the lead group with 14 minutes on the ‘Passo del Turchino’ or ‘who-wins-on-the-Turchino-wins-the-race’. He not only won the Tour de France twice, he did it with a ‘martian’ dominance. In 1949, there was a 14’ difference...

The second first case of the trickle..drip drip, drip,ocrelizumab and COVID-19 vaccines

In this individual ocrelizumab was used for 2 years. The person was vaccinated about two weeks after last infusion and the second Pfizer dose 3 weeks later. Nearly 3 weeks later they tested positive for COVID-19, so had been infected. A few days later there showed an IgM response but no IgG response. But we are no wiser…were they going to seroconvert to make an IgG response? No time to find...

Will the real slim-shady please stand up?

Vitamin D is one of the biggest confounders in MS clinical trials. It’s like a chess piece, where every move has an effect on the outcome. This latest piece of research from Romania studying the effect of Copaxone (immune modulator) versus prednisone (steroid) on circulating immune complexes (auto-antibodies) in RRMS, shows exactly this. The investigators found low serum levels of immune...

The Trickle begins..waiting for the Flood! Blunted vaccine responses and CD20-depleting antibodies

The case reports are starting to arrive “We present a patient with MS on ocrelizumab, who received the Pfizer mRNA COVID-19 vaccine, and did not seroconvert 27 days after the second vaccine dose as measured by an FDA approved Anti-SARS-CoV-2 S assay”. He received his first dose of SARS-CoV-2 (Pfizer) vaccine 5 months after ocrelizumab infusion, followed by the second dose...

#MSCOVID19 MDs Saturday COVID Lunch

Politicians need to do more for Vaccine Confidence….when they open their mouth, some times they need to put a sock in it. This study was done in January nearly 80% in UK would vaccinate but in France it is 40% and Germany Spain and Italy about 50%…I bet when the next survey is done we may see a dip and this has not been helped by stupidity by some politicians who are not doing their...

#MSCOVID19 don’t forget about the Blood Spot Test.

The Blood Spot test is a way to see if people are making a vaccine response. If you are, that is great news, but if you are not, its not the end of the world, as a T cell response may do the job. We have the first news from Israel, which was in part expected and not the best news for anti-CD20 and fingolimod users. But this is based on the Pfizer vaccine. We still need to know about Astrazeneca...

Becoming an MS outlier: the manual

MS outliers are pwMS that are different from all other people diagnosed with the disease. Being an outlier could go both ways. Some pwMS develop significant disability very short after being diagnosed while others live with the disease for decades and are still out and about. The problem is we cannot reliably predict the disability trajectory of pwMS at diagnosis. Observations in big groups of...

Q&A. Its April the First, Not Sure I can make a Joke this year.

ProfG has had an accident. It seems it has given him brain damage, so he is thinking of quitting clinical neurology to focus on gardening, private practice and MS prevention. We all know 2020 was a shitty year as far as UK MS research goes. Traditionally we and others have made some poor taste joke on this day but, we don’t have to make it up, it has happened with all its consequences for...

How much dimethyl fumarate gets in the brain

A couple of weeks ago someone asked about the penetration of dimethyl fumarate into the central nervous system. The active breakdown product of DMF is monmethyl fumarate. T Max is the time to the maximal concentration Edwards KR, Kamath A, Button J, Kamath V, Mendoza JP, Zhu B, Plavina T, Woodward C, Penner N. A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects...

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