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The COVID19 brain

Letter by British Rhinological Society and Ear, Nose & Throat UK Although severe acute respiratory syndrome (SARS) has been the hallmark of severe COVID19 infection, anosmia (lack of smell) and hypogeusia (the reduced ability to taste), headaches/dizziness have also been reported. Is COVID19 neurotropic? We don’t have hard data to support/refute this beyond history from those so far...

Natalizumab and the Lung

The ABN is saying natlaizumab is OK, but have they thought about the science? ProfG has asked if there is a literature on neurotrophism from coronavirus? If there is would you inhibit surveillance. This is not unknown for this type of virus…food- for thought. But the main route of entry of COVID-19 into cells is via the ACE-2 receptor. This is very low in the CNS in humans. source Brainseq...

The Real McCoy or Poundstretcher CD20 antibody

Comparison of rituximab originator (MabThera®) to biosimilar (Truxima®) in patients with multiple sclerosis. Perez T, Rico A, Boutière C, Maarouf A, Roudot M, Honoré S, Pelletier J, Bertault-Peres P, Audoin B. Mult Scler. 2020 Mar 17:1352458520912170. BACKGROUND:Rituximab’s originator MabThera® or Rituxan® has demonstrated high efficacy in multiple sclerosis (MS). Because of the patent...

COVID Breakfast. What I’m using for Loo paper this week…EAE

Who reviews this stuff? I am not going to give this paper the dignity of an citation to you to help the altmetric, but part of our job is to call poor animal experiments. However, this is one of the reasons why EAEologists are living on borrowed time and if COVID-19 does not get them, then any ethical review panel should. This is where international Societies have to step up to the plate and...

Guest Post: Dr Richard Nicholas

The impact of COVID-19 in multiple sclerosis: a substudy of the UK MS Register We need to understand more about COVID-19 urgently, and you can help. COVID-19, the coronavirus infection, is devastating the health and jobs of millions around the world, and is now in increasing in the UK with a major impact on all of our lives. People with multiple sclerosis (pwMS) are a susceptible group both due...

COVID Breakfast We all ignore the google doodle

I was one the train a few days a go listening to a bloke on the phone to his mate. He thought because he had the flu vaccine enough times so he was immune to the covid-19 causing virus…Luckily for them they were young enough that they will probably survive their misconsceptions, but for our parents and grand parents, this attitude is what will send some of us to our makers…Funny I...

#MSCOVID Information for Health Care Professionals

If you are a HCP professional you may be interested to read the experience of some HCP from China. The handbook focuses on the real-time hotspots of the COVID-19 epidemic. It provides detailed and comprehensive answers to potential questions for diagnosing and treating patients in different types. Treatment methods to treat the critically ill Efficient clinical decision-making strategies for...

Drug induced lymphopenia and evidence of infection

I will just put this up without to much discussion but it suggests that the lymphopenia associated with dimethyl fumarate and fingolimod are not really linked to noticably higher infection rates in the real world setting. This view has been repeated for many other agents that blood cell numbers do not appear to correlate with disease activity. Now it may be if you drill down on specific subsets...

It is harder to be a drummer if you have progressive MS.

We have been making the argument that we have to #thinkhand, notably when we do clinical trials in MS. This is based on the idea that the problems in MS are related to thelength of the nerve tracts, so if you ge lesions anywhere in the nervous system, the longer nerve tracts are more likely to get a lesion and the more lesions you get in a tract the more likely that disability occurs. Eventually...

#COVIDMS. Breakfast COVID.

There has been terrible news, so don’t choke on your breakfast. What is it…No….Not that the latest trial on an anti-virals has failed…you are desensitized to failed trials:-). You guys are used to that but did you know The Restaurants and Pubs have been closed!!! So now you can’t make anymore of those jokes about me and MD2 nipping down the road for a Swifty…...

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