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Is this the next treatment for MS…If you have psychosis?

We all have heard about BioRXiV (Bioarchive), where people can deposit their preprints before publication on a journal. Now there is not MedRXiv (Medarchive). All that needs to be done is link this up to Pubmed and we can cut out the middle man (publisher). A free archive that is open access and you get rid of the impact factor and the publishing mess in one easy swoop. What’s not to like...

No sooner have we had a Worms trial, but a vitamin D trial is reported. My time capsules are coming home. Maybe my type writter got stuck.

This study reports the trial of vitamin D + beta interferon verses vitamin D and the vitamin D trial fails. In my time capsule, I had this one as a fail too, just as the WORMS study failed to meet its endpoint too. You say I am saying this, after the event, which is true…but my time capsule for microbiome trials were planted about three years ago and they say the same thing. Academics are...

WORMS for MS

This study has been sometime coming and was I think probably originally based on the idea that a worm infection can drive a TH2 (anti-inflammatory) from a TH1 (pro-inflammatory) response. I think there were a number of studies planned, but this study from Nottingham passed the finish line. In this study people were infected with the hookworm parasite and I guess became biobombs as the worms would...

Human MS becomes EAE again, as its T cells that springs out in twin studies

In the new era of preprint papers you can put your stuff online, even before it is reviewed. Todays offering looks at twins, one with MS and one without an MS diagnosis. However when they look at the twin without a diagnosis, they find MRI features that they think could be early MS. These people are in what we call the prodromal phase. In this study they look at the immune component and conclude...

Brain volume loss in MS

Cognition (thinking, memory and learning) is known to be affected in MS. This is more so in progressive MS. In a study last year, it was found that those with more structural damage to the brain at baseline were more likely to have cognitive issues. And more likely that not cognitive issues were encountered if the brain cortex was involved (the area comprised of the surface of the brain where...

Oh, George!

The last time I saw George Ebers was at the European Charcot Foundation meeting in Baveno in 2017. I sat next to him and we had a long chat about MS and his new life in Canada. George had lost his anger and was very content with life. I learnt about all his projects on his farm; his windmill restoration project, his fence building, on being a carpenter and the summer water sports on his lake. I...

Half way to explaining multiple sclerosis

Genetic roots of multiple sclerosis This paper is open access and so for the more adventuous and people with an interest in genes, I suggest that you read the paper. If not I think the abstract and summaries say sufficient. Genes focus interest on the microglia. I would say about time. There is a clear CD4 bias in the thought process as they focused on CD4 naive T cells and from a personal point...

HSCT guidelines. Have a read if interested

Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE). Sharrack B, Saccardi R, Alexander T, Badoglio M, Burman J, Farge D, Greco R, Jessop H, Kazmi M...

Diabetes drug to the rescue. Making old cells young again

As you get older you do not repair as well, compared to when you are younger. This has been known for some time and a few years ago Prof Franklinstein sewed mice together and determined that young macrophages could allow old mice to repair. So it is an obvious thing to look for the elixior of youth. In other studies a blood protein promoted youthful effects in nerves Metformin is a treatment...

ARRIVE?. It won’t unless it gets enforced

As you know part of my job is to talk about the animal work we do and so it is appropriate that I comment on animal issues. (a) So you can understand a bit more on what we do and (b) so you can understand on the regulatory environment that we and others work in. I recently commented on the ARRIVE guidelines, which I teach to the students because it can help with experimental design. These are...

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