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ProfG has turned into a Smurf…Dear Neuro stop him turning into Papa!

ProfG has been banging-on about “Treat early and effectively to save brain”, until he is blue in the face….So much so, that he has turned into a Smurf Sadly there are still many of his colleagues that don’t buy into this… and follow the mantra of “There….There, we’ll get ya a nice wheel chair” The vast majority of neuros and pharma bods still...

Shot down in flames before the VirtualMS dust has settled

Last weekend marked the eightieth anniversary of the Battle of Britain. In 1940, many planes were shot down in flames. Whilst this can happen to planes, this can also happen to ideas. Some of them take some time to be shot down, but sometimes they it takes less time. Who would have thought that some are shot down before they take off! This is super scientific so read on if interested OK not alot...

T cells bite the dust

An interesting presentation from this years MSVirtual2020 was presentation by Dr Beatrice Wasser on ‘GlcNac signalling to reduce T cell pathogenicity in MS’. Abstract Background: Both adaptive and innate immune cells infiltrate the CNS during multiple sclerosis (MS) and in its animal model experimental autoimmune encephalomyelitis (EAE). Pathogenic T cells are known as key drivers of...

Natalizumab EDI

As you all know natlaizumab is typically dosed at 4 week intervals = standard dose interval. This stops lymphocytes and probably monocytes entering the brain and so stops immune survellience of the brain, exposing people to risks of brain infection with JC virus that causes PML By extending the interval to 6 weeks (extended dosing interval = EDI). This seems to reduce the risk of PML without...

It’s not just MS #mscovid19

I haven’t done one of these for a while. The CoOVID-19 publication epidemic has continued at a rate of knots and there is lots of stuff to give us a laugh. So you may not be surprised that COVID-19 in the UK and USA has made us rush to the drinks cabinet Problem drinking before and during the COVID-19 crisis in US and UK adults: Evidence from two population-based longitudinal studies...

What is MTR?

What is MRI? is one of the most read educational pieces on the blog. MRI lets us look in the brain, but the problem is no one really knows what the images mean. They corelate with this and they correlate with that, which means it has a woolly relationship with anything. MTR (magnetization transfer ratio) is going to be an important one because it is being used to assess the sucess of...

VV where are you?

Anyone who have been a long-term reader of the blog know that every now and then a character comes along who likes to challenge the team. The nemesis of TeamG and the peoples champion who wants to “Stick it to the man” We get Sid from the Cup (Siddcup) and then we had DrDre the rapper from Bradford . ProfG used to get his character assassinated by Joanie and for those with a distant...

Pregnacy delays MS

Queen Victoria used to have terrible period pains…so how did she get rid of this…yep she had 10 kids and so must have been constantly pregnant or was it a way to keep MS at bay? Women with previous pregnancies and childbirths had a later onset of CIS compared with those who had never been pregnant with a median delay of 3.3 (95% CI, 2.5-4.1) years. How would this work…hormones I...

Fancy genetic stuff tells us..guess what?..Yep that memory B cells are useful targets..OK I’m biased:-)

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG, Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F.Nat Genet. 2020 Sep 14. doi:...

MS is on the Global Increase

Click to access Atlas-Epidemiology-report-Sept-2020-Final-EN.pdf Get the Report Here The global prevalence of MS is estimated at 36 people per100,000 people, which means there are 2.8 million peopleliving with MS worldwide. This equates to 1 in every 3,000 people living with the disease. This global estimate has increased from 2.3 millionpeople in 2013, which is consistent with stated increasesin...

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