CategoryCauses

MS and other neurological disorders in India

This freely accessible article published in Lancet Global Health is the most comprehensive data on the prevalence of neurological disorders across India to date. Around 18% of the worlds population live in India and like other nations they also have a significant level of morbidity related to those with neurological disorders. But, owing to a lack of resources as well as cultural taboos, it has...

Gut instinct, the gut microbial changes in MS

It’s probably not the first time that you’ve heard about gut microbes and MS. Particularly, the role that they may play in the development and regulation of MS. Almost every study published in the literature has demonstrated differences in the gut microbiome in MS patients vs. healthy controls with the possibility that interventions on diet and the use of probiotics may have a...

Neurofilaments have it – the story behind smouldering MS

Recently, smouldering MS or chronically active MS lesions have become an entirely new entity in disease progression. They are characterized by a rim of activated microglia/macrophages in both RRMS and progressive MS and are linked to more aggressive disease. These lesions are visible on a type of MRI called susceptibility-based imaging and individuals with MS can have 0, 1-3, or ≥4 of these...

Now a virus that isn’t associated with MS

Cytomegalovirus (CMV) is related to the herpes virus that causes cold sores and chick pox. It gets its name from making cells swell/go big. Like EBV Once you have the virus, it stays in your body for the rest of your life. Your immune system usually controls the virus and most people do not realise they have it. But CMV can cause serious health problems in some babies who get the virus before...

Pets and MS, is there a link?

Over the years I have been asked about just about everything and anything that can cause MS. But, this is a new one on me. Do pets cause MS? Specifically, is childhood pet ownership or exposure linked to the development of MS. The concept is not as far fetched as it may initially appear. For instance, early on there were concerns over canine viruses causing MS. Pet ownership is common in the...

The causative link of EBV and MS explained?…ProfG will be happy

ProfG has been on an EBV crusade, but why or how does it cause/trigger MS? HLA-DRB1*15:01 is a coreceptor for Epstein-Barr virus, linking genetic and environmental risk factors for multiple sclerosis. Eur J Immunol 2021. The strongest genetic and environmental risk factors for multiple sclerosis (MS), an inflammatory central nervous system disease, are HLA-DRB1*15:01 and Epstein-Barr virus (EBV)...

Not so much of a cure then? Anti-CD20s fall short of the finish line.

Drum roll please!…. It was only a matter of time before someone designed this experiment. Albeit, it’s in an animal model, but the content is still by far the juiciest I’ve seen in MS research this year. The major finding of this work is that depleting B cells alone using anti-CD20s doesn’t get rid of all inflammation in the neuronal tissue. The authors of this work...

Curing MS

Barts-MS rose-tinted-odometer: ★★★★★ I have been asked many times if we can cure someone who has MS. I have tried to explain what an MS cure may look like many times on this blog and have actually published articles defending the definition.  I explained in a previous post that you may be cured of your MS, but still, have worsening or progressive disease. The difference between progressive...

The Plasma cell story – how MS begins and ends

In 1875, a famous German scientist; Wilhelm Gottfried Waldeyer Hertz, described an immune cell with a large cytoplasm (the space within the cell aside from the nucleus), he was the first to name it the “plasma cell”. We now know that this large cytoplasm hosts a production line that is solely dedicated to antibody formation (up to 10,000 molecules per second per cell). They account for less than...

Childhood EBV and contraception

If EBV is the cause of MS then you expect that everybody should be infected with EBV. If people are not infected and get MS the causal link may become tenuous. In this study they look for EBV negative children with MS and find negative people. Does ProfGs idea go down in flames? They find 25/189 cases and so you would say the EBV hypothesis is on dogey ground.. They look harder and now come to...

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