CategoryCauses

Your genes and you

Genetic studies in MS are a vast mountain and not simply a mound, with sample sizes ranging into the thousands. Climbers and mountaineers seek out free-standing mountains (i.e. mountains that are not part of a mountain range) as their relief from other peaks of equal height makes them an impressive sight to behold. The Matterhorn, Switzerland – a free-standing mountain Do genetic studies...

Your race in MS

Race, ethnicity, creed – all architectural descriptors, some complex, others less so, depending on your perspective. When it comes to illnesses however, you are largely referencing race (the inheritance of your DNA) and ethnicity (the branch of race that your DNA occupies). We may be different in a number of ways, but our illnesses are a great equalizer. There is no such thing as race...

Inhibition of B cell survival factors does not inhibit MS

You know me, I love to write papers, pharma seem to hate it, so I say to them just give me the data and save yourself a few grand paying medical writers. OK, they can’t dictatate what I am going to write, but the data generally speaks for itself. They just don’t want to let the data out:-(. After the excitement of HSCT- thursday…. and friday, its back to reality. This post...

Human MS becomes EAE again, as its T cells that springs out in twin studies

In the new era of preprint papers you can put your stuff online, even before it is reviewed. Todays offering looks at twins, one with MS and one without an MS diagnosis. However when they look at the twin without a diagnosis, they find MRI features that they think could be early MS. These people are in what we call the prodromal phase. In this study they look at the immune component and conclude...

Brain volume loss in MS

Cognition (thinking, memory and learning) is known to be affected in MS. This is more so in progressive MS. In a study last year, it was found that those with more structural damage to the brain at baseline were more likely to have cognitive issues. And more likely that not cognitive issues were encountered if the brain cortex was involved (the area comprised of the surface of the brain where...

Half way to explaining multiple sclerosis

Genetic roots of multiple sclerosis This paper is open access and so for the more adventuous and people with an interest in genes, I suggest that you read the paper. If not I think the abstract and summaries say sufficient. Genes focus interest on the microglia. I would say about time. There is a clear CD4 bias in the thought process as they focused on CD4 naive T cells and from a personal point...

Shrinking MS lesions – anything to take note of?

Are you surprised that some MS lesions shrink in size? It has nothing to do with quantum mechanics – Planck’s constant or Pym particles. However, it has been noted for a while now that in some individuals their MS lesions could shrink. The prevailing hypothesis is that shrinking lesions represent resolution of the underlying inflammation or even possibly repair. Others believe, like...

American Military show that MS starts years before it shows itself

Migration data suggests that people contract the MS trigger before the aga of 15 but we know from clinical studies that it often doesn’t show itself for years later. However it appears that this grumbles on for many years before it rears its ugly head. The American Mitltary is a big beast full of healthy young people who get good medical check-ups. They have their bloods taken and stored...

ECTRIMS 2019: Biomarkers

ECTRIMS, Stockholm Biomarkers session Finally in the ECTRIMS mood! Hundred Unbelievable that an year has passed already since the last one, but before I get maudlin, lets get some focus back in. I’ll be co-chairing a session this Friday with Dr Salzer, from Umea University, Sweden (Rituximab man). You can see all the topics of discussion in the program above, but for those of you who...

The central vein sign in MS

Multiple Sclerosis (From Reich et al NEJM 2018) Last week, I blogged on smoldering lesions visualized on MRI as a marker of progressive MS. Today, I will discuss the central vein sign. This publication in JAMA by the MAGNIMS group (a group of MRI bods from the world over) is therefore, timely. If you haven’t heard of the central vein sign, it is the presence of a vein within an MS lesion...

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