CategoryCauses

Human MS becomes EAE again, as its T cells that springs out in twin studies

In the new era of preprint papers you can put your stuff online, even before it is reviewed. Todays offering looks at twins, one with MS and one without an MS diagnosis. However when they look at the twin without a diagnosis, they find MRI features that they think could be early MS. These people are in what we call the prodromal phase. In this study they look at the immune component and conclude...

Brain volume loss in MS

Cognition (thinking, memory and learning) is known to be affected in MS. This is more so in progressive MS. In a study last year, it was found that those with more structural damage to the brain at baseline were more likely to have cognitive issues. And more likely that not cognitive issues were encountered if the brain cortex was involved (the area comprised of the surface of the brain where...

Half way to explaining multiple sclerosis

Genetic roots of multiple sclerosis This paper is open access and so for the more adventuous and people with an interest in genes, I suggest that you read the paper. If not I think the abstract and summaries say sufficient. Genes focus interest on the microglia. I would say about time. There is a clear CD4 bias in the thought process as they focused on CD4 naive T cells and from a personal point...

Shrinking MS lesions – anything to take note of?

Are you surprised that some MS lesions shrink in size? It has nothing to do with quantum mechanics – Planck’s constant or Pym particles. However, it has been noted for a while now that in some individuals their MS lesions could shrink. The prevailing hypothesis is that shrinking lesions represent resolution of the underlying inflammation or even possibly repair. Others believe, like...

American Military show that MS starts years before it shows itself

Migration data suggests that people contract the MS trigger before the aga of 15 but we know from clinical studies that it often doesn’t show itself for years later. However it appears that this grumbles on for many years before it rears its ugly head. The American Mitltary is a big beast full of healthy young people who get good medical check-ups. They have their bloods taken and stored...

ECTRIMS 2019: Biomarkers

ECTRIMS, Stockholm Biomarkers session Finally in the ECTRIMS mood! Hundred Unbelievable that an year has passed already since the last one, but before I get maudlin, lets get some focus back in. I’ll be co-chairing a session this Friday with Dr Salzer, from Umea University, Sweden (Rituximab man). You can see all the topics of discussion in the program above, but for those of you who...

The central vein sign in MS

Multiple Sclerosis (From Reich et al NEJM 2018) Last week, I blogged on smoldering lesions visualized on MRI as a marker of progressive MS. Today, I will discuss the central vein sign. This publication in JAMA by the MAGNIMS group (a group of MRI bods from the world over) is therefore, timely. If you haven’t heard of the central vein sign, it is the presence of a vein within an MS lesion...

Chronic lesion activity in MS as seen on MRI

If you’d asked an year ago on whether I though MRI had a role beyond diagnosis in MS? My answer would have been an emphatic ‘NO’. The Achilles heel of MRI has always been the difficulty of standardizing scanning techniques to a large scale population level and adapting these accurately to work seamlessly during the day-to-day shortcomings of clinical imaging facilities within...

Thyroid disease with Alemtuzumab – risk mitigation

There is a popular old saying in English – “forewarned is forearmed”. Prior knowledge that something is going to happen offers tactical advantage, whether you’re at war or simply everyday life. The difficulty, however, is that more often than not we are transfixed by the detail of the matter, resulting in numerous avenues of investigation in the process, some of which are...

Is cholesterol truly bad for you?

Low-density lipoprotein particle, apolipoprotein B (blue) is surrounded by various forms of cholesterol (orange and yellow) and other lipids. JUAN GAERTNER/SCIENCE PHOTO LIBRARY Scientists have known for a long time that cholesterol like other basic food components forms an essential component in a healthy human body. It forms the cell membrane architecture (or the cell wall), helps produce the...

Translate

Categories

Recent Posts

Recent Comments

Archives