CategoryCauses

Sepsis in MS patients and Intensive care admissions

Sepsis (or blood infection) is a dangerous thing. I remember first realising this as a Junior doctor in respiratory medicine, when an audit of pneumonia admissions revealed a mortality of 60%. Sadly, this has not improved by much even with the latest antibiotics. As I rotated through, transplant medicine, haem-oncology, and finally into ICU, I found myself forever pre-occupied with watching the...

EBV and MS

Bar-Or A, Banwell B, Berger JR, Lieberman PM. Guilty by association: Epstein-Barr virus in multiple sclerosis. Nat Med. 2022 . doi: 10.1038/s41591-022-01823-1. ProfG has been banging on about EBV and MS as long as I have known him, but when two papers come together (one showing that you get infected before you get MS and the other one suggesting a mechanism of how T cells are activated in (i)...

MS is Colour Blind

Nature (Genetics) or nurture (environment)? Historically it has been indicated that there are racial differences in terms of MS susceptibility, which was considered to be a white anglo-saxon condition. However, come to Barts and you can see that idea is a load of Tosh and MS comes in every flavour and we have a very diverse range of people affected by this condition. In this study from USA...

Abusing MS

We all know that “life” is a sexually-transmitted disease with 100% mortality, but a few years ago it was suggested that MS was a sexually-transmitted disease and it caused a great deal of uproar….I was at ECTRIMS when the news broke and remember the reactions of neuros from the same group as the author….It wasn’t pretty. As MS is diagnosed in Children…..I am...

Brain inflammation in MS, ongoing activity leads to axonal breakdown

In so far as your immune cells are concerned there is a vast difference between the brain and the rest of the body . In fact, the only resident immune population in your brain are the microglia and the perivascular (surrounding blood vessels) macrophages. These immune sentinels change their baseline identity depending on the disease (see the two figures below). This segregated state also means...

A study from Norway finds that a good BCG vaccine response reduces MS risk

Figure: BCG vaccination and its many effects on the adaptive and innate immune system (source: Frontiers) We don’t really know what triggers MS. Genetics, EBV/other viruses, vitamin D and pathological levels of stress have all been associated with the onset of MS. In a recent study, investigators have now also found an association with Tuberculosis (TB) – namely it’s vaccination...

Microbiomics

The hot topic of immueobiology is how the gut microbiome (bacteria within the gut) affect autoimmunity. This leads some people to recommend a faecal transplant when you clear out your own bacteria and then drink someone elses stool….This has given rise to new branch of science (sh1omics), which is the study of bacterial in the gut. However, is this where the action occurs? Many years ago...

Ready to be a herbivore?

As we’re inundated by the food market about the ‘non-chicken, chicken’ and ‘impossible’/’beyond meat’ burgers, the big question outside of what’s good for the environment is whether there are sufficient health reasons to switch. For those looking for the prod the outcomes of this study may be just that. The study I’m referring to is a large...

Brain resilience correlates with cognitive performance in MS

What causes cognitive issues in MS? Not a straightforward question to answer. It has been postulated that there is a global cognitive dysfunction in MS largely due to connectivity issues (for example, thalamic grey matter volume loss and also lobar connectivity due to interruptions by MS lesions), but also secondary to cortical MS lesions. What is unknown is the resilience of the whole system and...

Mass Cytometry finds B memory cells in MS spinal fluid

Flow cytometry occurs when cells are put through a “machine that goes ping” in fact it is a machine that makes cells pass through a laser and the scatter of the laser light is detected and converted into an image. The cells can be labeled with antibodies. It is one colour per antibody. Historically you would do one or two colours but the latest machines can pick up about 15-20 colours...

Translate

Categories

Recent Posts

Recent Comments

Archives