CategoryCOVID-19

#MSCOVID19: T-cell response on ocrelizumab

Barts-MS rose-tinted-odometer: ★★★★★ As you know the vast majority of pwMS on anti-CD20 therapy who get COVID-19 or for that matter any other viral infection recover. In other words, their immune systems work despite blunted or absent B-cell or antibody responses. This study presented yesterday at the AAN meeting confirms that ocrelizumab-treated patients who get COVID-19 have good robust T-cell...

MDs Delayed Saturday mid morning Snack/COVID lunch

P.S. ProfG has a sense of humour and has not taken offence by the contents of this post So for this/last weeks tasting menu we start with Alemtuzumab and antibody responses…I predict good news based on natural infection Iovino A, Olivieri N, Aruta F, Giaquinto E, Ruggiero L, Spina E, Tozza S, Manganelli F, Iodice R. Alemtuzumab in Covid era. Mult Scler Relat Disord. 2021 Mar 18;51:102908...

#MSCOVID19: antibody testing post-vaccine

Barts-MS rose-tinted-odometer: ★★★ Should I get an antibody test to prove that I have responded to the COVID-19 vaccine? No, you shouldn’t. Most diagnostic COVID-19/SARS-CoV-2 antibody tests are based on detecting antibodies to the so-called nucleocapsid protein and not the spike protein, which is the protein or immunogen used in the current vaccines. There are, however, a few private...

#MSCOVID19: adenoviral vector vaccines

Barts-MS rose-tinted-odometer: ★ You may have heard that the FDA has suspended dosing of the J&J COVID-19 vaccine as they have identified 6 cases of thrombosis in young woman similar to that described below with the Oxford-AstraZeneca vaccine (see articles below).  It looks like the complication may therefore be due to the vectors, i.e. adenoviruses, rather than the SARS-CoV-2 spike protein...

The aftermath

Barts-MS rose-tinted-odometer: ★★ I am increasingly being asked about what is going to happen to MS research and clinical services post-COVID-19. The question is being asked as if I am some kind of futurist or prophet. I am not. My response is let’s focus on the here and now. The following on the issues that need to be addressed this year: Untreated or under-treated MS. There is has been a drop...

Should we abandon the ADIOS study?

Barts-MS rose-tinted-odometer: ★★★ If you have been on ocrelizumab for two years would you be prepared to participate in the ADIOS (adaptive dosing ocrelizumab study)? One of the study arms would mean that you would not receive any ocrelizumab until you had a relapse or new MRI activity. In other words, we would be using ocrelizumab like we use alemtuzumab or cladribine, i.e. as an immune...

#MSCOVID19 Astrazeneca Vaccine and Blood Clot information

Here are some links to information about the Astrazeneca vaccine and small risk of blood clotting, which have just gone live. Hopefully these will help with your questions. Press release MHRA issues new advice, concluding a possible link between COVID-19 Vaccine AstraZeneca and extremely rare, unlikely to occur blood clots – GOV.UKThe benefits of vaccination continue to outweigh any risks...

The second first case of the trickle..drip drip, drip,ocrelizumab and COVID-19 vaccines

In this individual ocrelizumab was used for 2 years. The person was vaccinated about two weeks after last infusion and the second Pfizer dose 3 weeks later. Nearly 3 weeks later they tested positive for COVID-19, so had been infected. A few days later there showed an IgM response but no IgG response. But we are no wiser…were they going to seroconvert to make an IgG response? No time to find...

The Trickle begins..waiting for the Flood! Blunted vaccine responses and CD20-depleting antibodies

The case reports are starting to arrive “We present a patient with MS on ocrelizumab, who received the Pfizer mRNA COVID-19 vaccine, and did not seroconvert 27 days after the second vaccine dose as measured by an FDA approved Anti-SARS-CoV-2 S assay”. He received his first dose of SARS-CoV-2 (Pfizer) vaccine 5 months after ocrelizumab infusion, followed by the second dose...

#MSCOVID19 – AstraZenca Vaccine Update

Barts-MS rose-tinted-odometer: ★★ In response to a comment from one of our readers. We have not directly addressed the thrombosis AstraZeneca vaccine issue as we are not vaccinologists or haematologists. But as there seems to a lot of anxiety around this issue a short blog post about the potential risks may allay your fears. I received the following email, from Professor Marcel Levy (Consultant...

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