CategoryCOVID-19

The writing was on the wall for fingolimod…But it was written in invisible ink:-( The destiny of vaccination responses.

When I was an scientific amoeba  beta interferon came along and worked in MS then we had a sea of papers in EAE telling us that beta interferon was immunomodulatory in mice. I thought who cares at that point as you know the answer in humans, why waste animals? Also you could see it was rather rubbish in animals except in the study that used human beta interferons in mice….They should have...

Splosh, Splosh Splosh, the drips are increasing Vaccination and fingolimod and anti CD20 are like oil and water…Not mixing

Today we have the first interim analysis of vaccination data from Italy they have looked at over 700 people on their way to studying 2000 people. So I think we can safely say in terms of anti-CD20 and fingolimod, that they are problem children in terms of the antibody response Effect of SARS-CoV-2 mRNA Vaccination in MS Patients Treated With Disease Modifying Therapies. Sormani et al. Background:...

Having Two Pricks. You are not alone!

No nothing to do with Lizards:-) but the Jabs…..Well done MS-Britain you want the Jab…but let’s finish the job/jab Highlights •94.4% of people with multiple sclerosis (MS) would accept a COVID-19 vaccine•People of increasing age and influenza vaccinations were more likely to accept•Safety concerns and lack of information were top reasons for not getting a vaccine•51.7% of people...

COVID19..Drip, Drip Drip….B cell repopulation determines the ability to give antibody response after COVID-19 vaccination

Learning from other conditions is useful. As there are more people with rheumatoid arthritis than MS we will see alot of anti-CD20 papers with rituximab. There will be subtle differences compared to ocrelizumab. So when you read the paper that says the vaccine response to anti-CD20 is unknown….it’s not its getting less unknown by the day. If you are taking ocrelizumab you should...

#MSCOVID19

Sormani, MP et al. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context. SSRN:  Background: It is unclear how multiple sclerosis (MS) affects the severity of Covid-19. Methods: Hospitalization, Intensive Care Unit (ICU) admission and death after Covid-19 diagnosis of 1362 MS patients were compared to the age and sex-matched Italian population in a retrospective...

Antibodies don’t hang around for ever, lets hope the COVID-19 virus doesn’t either

Whilst we are on about antibody responses, this is a study from UK where people got pfizer or astrazeneca vaccine at about 10-11 week intervals and it was evident that antibody levels dropped overtime, so after “Frazer day” (OK abit amateur dramtics) on monday when we were all let loose to spread virus at will. Frazer from Dads Army Remember that the level of protection could drop a...

Advice from Van the Man Van-Tam

So to keep you in the loop, my spies have intercepted a communication by Prof Van-Tam, OK…it was sent to the Doctors. COVID-19 causes a variety of symptoms, Dr Angry says symptoms of COVID include loss of taste and you can see this symptom is on the increase all around London. Get ready for a Booster in Autumn 2021 Anyway back to the Medical Van th Man..He wrote: As you will be aware...

CD20 and COVID-19

The CD20 onslaught continues at a pace and there is no refuting it, anti-CD20 depletion blocks the formation of vaccine response. I have seen this occur irrespective of the vaccine that was used. I am sorry to say if you are on anti-CD20 you are going to see this over and over again…it will be like-water torture, drip, drip, drip. Yep and I control the tap (faucet for our American readers:...

Euro2021….The problem for CD20.

The UK has been deluding itself and its citizens (So what’s new there?) The French and Italian Data show worse signs with anti-CD20 treatment, Swiss data show poor vaccine response in both T and B cells after CD20 depletion and the Dutch support the Italians on delaying tactics. It seems that the UK government (public health) is coming under fire for suggesting everything is fine with the...

Approach to COVID-19 vaccination. Someone else’s view

If you have been reading the Blog you are essentially getting a micro-opinion from ProG or sometimes maybe me. What do others think…I may ask sometimes do others think:-), but there are other opinions and so I give you another one. I am not going to make any comment. If you are interested you can read and then say what you think or ask a question. Enjoy Woopen C, Schleußner K, Akgün K...

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