CategoryLab Lessons

MS one disease or should we suggest one syndrome or are we going to split it into smaller diseases based on different targets.

Antibody signatures in patients with histopathologically defined multiple sclerosis patterns. Stork L, Ellenberger D, Ruprecht K, Reindl M, Beißbarth T, Friede T, Kümpfel T, Gerdes LA, Gloth M, Liman T, Paul F, Brück W, Metz I. Acta Neuropathol. 2020 Jan 16. doi: 10.1007/s00401-019-02120-x. [Epub ahead of print] Early active multiple sclerosis (MS) lesions can be classified histologically into...

The war on sugar (more posts below today)

Barts-MS rose-tinted-odometer ★★★  Just back from the NMSS ‘Pathways to Cures’ meeting in Washington DC during which we pledged to  STOP, RESTORE and END multiple sclerosis.  The END refers to prevention. We discussed at the meeting modifiable risk factors that could be tackled to reduce the incidence (new cases) of MS and one risk factor childhood and adolescent obesity. One...

How Do you Want Your Information?

Hopefully you consider the Blog as a source of information, but how do you want that information delivered? Do you want it in a Faberge Egg or a paper bag? The paper bag costs $10 and the egg costs $5,000. Sure I know if it was a real Faberge egg it would be more, and $10 for a paper bag, you say I’m having a laugh, but the question I pose is a real question. I do work and I report it...

Interogating MS with new technology, it’s a T & B cell co-operation thang.

With new technology is was not a question of if, but a question of when the protein production array of individual cells will be done, You can now look for the antigen-specific receptors of each cell to find out what they target is you can look at the proteins they make to say what cell types are there and this latter aspect was the focus of this study. They got the protein signatures...

Re exercise in MS: should we be flogging a dying horse?

Barts-MS rose-tinted-odometer ★★★  I am at the NMSS’ Pathways to Cures think tank where exercise is a major theme in terms of restoring lost function. A lot of discussions have been about how we motivate and get pwMS to exercise. Some suggested using motivational interviewing techniques and behavioural psychology to motivate and nudge pwMS to exercise. The elephant in the room is that some people...

Induction-maintenance

Barts-MS rose-tinted-odometer ★★★  By definition an immune reconstitution therapy (IRT) for MS is given as a short course, i.e. as a one-off treatment in the case of HSCT or intermittently as in the case of alemtuzumab or cladribine. IRTs are not given continuously and additional courses of the therapy are only given if there is a recurrence of inflammatory activity. IRTs have the ability to...

Premature Ageing

One of my colleagues, with whom I was co-authoring an editorial on smouldering MS, demanded I delete the section on premature ageing being a factor driving delayed worsening of disability in people with MS (pwMS). I refused so we had to pull the editorial. The fact that he is quite old and doesn’t like the hypothesis of brain & cognitive reserve being neuroprotective explains his position. He...

CSF vs. Blood neurofilaments

This blog post explains why blood neurofilament level monitoring is not ready for primetime and may never quite replace CSF NFL monitoring in pwMS.  Although blood neurofilament light chain (NFL) levels are a promising biomarker for monitoring MS inflammatory disease activity there are issues that need to be resolved.  We and others have shown that blood levels correlate with spinal fluid levels...

Biohacking comes of age

Barts-MS rose-tinted-odometer  ★★ You know something is happening when it gets its own review article in the New England Journal of Medicine. The review article in last weeks issue covers the science and medicine around intermittent fasting (IF) and its effects on health, ageing and disease. The article even includes a few lines on IF and its potential impact on MS.  In my ‘2020 Vision’ post...

Zero stars

Barts-MS rose-tinted-odometer – zero stars Some of our readers are not satisfied with the Swedish Gothenburg 50-year follow-up data on MS outcomes, I presented yesterday; they make the comment that the data is out of date. However, there are very few databases that have 50+ year follow-up data; one of them is the Swedish National MS Register. The following is the latest Swedish registry...

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