CategoryLab Lessons

Has NDG cured PML?

So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML. If you can remember from yesterday immune check point inhibitors. One...

COVID Breafast. What’s has space travel, COVID19 and the Science self-publicity machine got in common to help MS?….Maybe Too Late! has NDG cured PML?

The Space programme gave us a man on the moon , but in the process of that a lot of innovation was developed…like the Space Pen that I carry that writes upside down and underwater. Others include Artificial limbs. …Insulin pump. …DustBusters. …Shock absorbers for buildings. …Solar cells……Cold-Weather Wearables. …Foil Blankets. …Scratch...

Do you do your Science like your literature review?

Is there is a nasty little fact that we ignore as it doesn’t suit our case? We are desperate to be first to publish stuff. But if you don’t come first. Is it OK to ignore other peoples work to make it look like yours is more important? Because if you are willing to do this, what else do you ignore? This is relevant to MS because we see this and that paper on animal studies in Nature...

Detecting #MSCOVID19 infection. SPIN and SNOUT

Hello my name is Triska. I am working with DrAngry and ProfB and was due to do my student Lab project on anti-drug antibodies in MS. I have been told that the subject matter is top secret. However, things have changed and I have been doing a COVID-19 related study. You may know that you can detect the virus is you are infected. However, after you have been infected, you will make an anti-COVID-19...

MOGGIES miss the point. Right idea..wrong disease?

A couple of weeks ago I did a post asking “Should we be bricking it about taking anti-CD20 antibodies”. I apologise to the non-native English speaking readers…(e.g. Our American friends…:-) at the use of slang. I generally add a link on these things to help you understand and also it expands your knowledge of English. “Bricking it” derives from the idea that...

Why may alemtuzumab stop working in some people?

Have you ever noticed that when you have dandelions growing that if left to themselves you get long stemmed flowers, however if you cut the grass alot what you get are very short stemmed flowers One thing to come out of the lockdown is the going to be a lack of EAE experiments as these are considered non-essential during the COVID-19 crisis. Inddeed we were stopped from doing such experiments...

Dr Angry crank up the Machine…another project.

DrAngry is a bit of a boffin and has been making anti-drug antibody assays. We have a paper about to arrive on the anti-drug antibody (ADA) response of alemtuzumab. It is the “poster-girl/boy” when it comes to ADA as it causes then in so many people. It busts the myth that making a humanised antibody makes things less immunogenic (rejected by the immune system). It can cause about 60%...

#MSCOVID19 – cladribine

This post explains why I have started to refer to cladribine as a small molecule anti-CD20/CD19 therapy and why oral cladribine should be part of the exit strategy to treat MS during the tail of the COVID-19 pandemic. Although we use cladribine as an immune reconstitution therapy and often compare it to alemtuzumab it is, in fact, closer to anti-CD20 therapies in terms of its immunodepletion...

Re-inventing the wheel with different expensive spokes

Technology is a wonderful thing and allows us to go new places and to go old places to ask the same question with a different tool. Thirty years ago I collected a number of different anti-macrophage antibodies and did some staining of some EAE tissue and came to the conclusion that there were loads of different subtypes of macrophage or different activation, functional status and things like...

#MSCOVID19: wow!

I am on call at the Royal London Hospital and sitting in my office digesting some of my daily COVID-19 reading. However, something has just hit me between the eyes and I have to say wow aloud!  WOW!! The paper and editorial below show you just how infective SARS-CoV-2 really is and why we are not going to win this battle for our vulnerable people without an effective anti-viral and/or...

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