CategoryLab Lessons

News for alemtuzumabers

Prof G what can be done to manage my hyperthyroidism if I want to fall pregnant? Carbimazole is associated with an increased risk of congenital malformations, especially when administered in the first trimester of pregnancy and at high doses. Women of childbearing potential should use effective contraception during treatment with carbimazole. Carbimazole: increased risk of congenital...

Spanner in the works for intrathecal rituximab

Figure: To-and-fro bi-directionality of CSF flow in the brainBy © Nevit Dilmen, CC BY-SA 3.0 I get a sinking feeling in the pit of my stomach when I read this article. Starting out in science, one is considered smart when following the trends of the populist. As a seasoned scientist, when one continues to work in this way, one is just not being too clever. I am not being disparaging of those who...

More B cell stuff. Don’t deal with the B cells…Don’t deal with disease?

Longitudinally persistent cerebrospinal fluid B-cells can resist treatment in multiple sclerosis.Greenfield AL, Dandekar R, Ramesh A, Eggers EL, Wu H, Laurent S, Harkin W, Pierson NS, Weber MS, Henry RG, Bischof A, Cree BA, Hauser SL, Wilson MR, von Büdingen HC. JCI Insight. 2019 Feb 12. pii: 126599. doi: 10.1172/jci.insight.126599. [Epub ahead of print] B-cells are key contributors to...

What to do about my haloes?

Why do MS lesions with an iron halo continue to expand? The slowly expanding MS lesion or SEL is where the money or lack of money is. In my post ‘explaining why you are getting worse despite being NEDA‘ I mention SELs as one of the reasons that underlie progressive MS and are largely unresponsive or poorly responsive, to standard DMTs. Danny Reich’s team at the NIH have...

To B or Not to B..that’s is ProfG’s Atrophy Question

Effect of disease-modifying therapies on subcortical gray matter atrophy in multiple sclerosis.Sotirchos ES, Gonzalez-Caldito N, Dewey BE, Fitzgerald KC, Glaister J, Filippatou A, Ogbuokiri E, Feldman S, Kwakyi O, Risher H, Crainiceanu C, Pham DL, Van Zijl PC, Mowry EM, Reich DS, Prince JL, Calabresi PA, Saidha S. Mult Scler. 2019 Feb 11:1352458519826364. BACKGROUND:The effects of disease...

How Does Cladribine Work?

Here is a new offering from the CLAD lads :-), and follows on from the information that we got from the European Medicines Agency and from stuff in the public domain. This is not a pharma supported piece of work and they may have different views of how cladribine works or how they want to portray how they think this works, but as usual for us, it contains ideas of the unknown. Things we and...

EBV infects T-cells

Why are experts important? In the so-called post-truth era experts are derided and ignored. Not at Barts-MS. Last Friday we held a lock-in to review and discuss our EBV research programme and bring in expertise from outside our group. We were fortunate to have card-carrying EBV experts, oncologists, B-cell biologists and protein and antibody experts around the table. A central plank of the EBV...

Brain Atrophy

ProfG has been addressing the issue of brain shrinkage and asking-Which agents are the best? We may not all agree on what is the best, but one can ask what is/are the worse. If we can address this problem and agree, then surely it is time to say “It’s rubbish! Throw it in the Bin!” (A comment I once heard at an MS Life meeting) The obvious answer is……yep you guessed...

Prof G how much brain have I lost this year?

How soon will MSers have brain volume measurements as part of their annual assessments? As a reader of this blog, you may be aware that ‘life is a sexually-transmitted age-dependent terminal neurodegenerative disease’. Homo sapiens, as a species, is pushing its biological capabilities to its limits. We have conquered most diseases that used to cull us before our mid-thirties and the end of our...

Blocking Calcium, Should we listen to mouse studies or plough on regardless

Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Witte ME, Schumacher AM, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M. Neuron. 2019 Jan 6. pii: S0896-6273(18)31123-1. Axon loss determines persistent disability in multiple sclerosis patients...

Translate

Categories

Recent Posts

Recent Comments

Archives