CategoryLab Lessons

Tea Time, HSCT inhibits brain infiltrating T cells

Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis. Harris KM, Lim N, Lindau P, Robins H, Griffith LM, Nash RA, Turka LA, Muraro PA. JCI Insight. 2020;5(2). pii: 127655. A recent study of autologous hematopoietic stem cell transplantation (AHSCT) for active relapsing-remitting multiple sclerosis (RRMS) showed efficacy in preventing disease...

Could diet be the new add-on DMT?

Barts-MS rose-tinted-odometer  ★ ★★ ★ ★ I gave my first on using diet as a potential symptomatic and disease-modifying treatment for MS and as a preventative therapeutic strategy in MS, last night. The symptomatic part of my talk was about food coma and using diet to prevent or reduce the impact of food coma. We are still studying why pwMS are so susceptible to food coma. I suspect it is because...

Progressive MS is a misnomer

Barts-MS rose-tinted-odometer – zero stars I am in Milan at the International Progressive MS Alliance Industry Forum Meeting. The aims of the meeting are to: Discuss challenges understanding and measuring progression and its impact on drug labelsDiscuss regulatory issues, opportunities and implications for drug labels and regulatory approvalsDiscuss links and opportunities for industry and...

I’m a vegan can I have antibody treatment?

This is up to you. it’s your choice. The important question is how do you make an antibody? I have to say all of them have their historical and technological origins in a furry beasty, notable mice and rats. You said “ I read that ocrelizumab was made from Chinese hamster ovary cells…. Is my ocrelizumab harvested inside a hamster?” Is the Hamster straining to push-out...

Science Fiction: Vitamin D

Failed vitamin D trial..Failed to infrom:-( ProfG has done a post on medical fiction. It is perhaps approriate to do a post on science fiction. As you know scientists are like sheep and they herd together and follow one and other. They stick close to the “dogma machine” and follow trends because, this is where money gets put. I have gone on the record of discussing a few. Some I have...

Astrocyte targets

The expression of MAFG in mice is high compared to human (Data from public data bases MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ.Nature. 2020 Feb 12...

Alemtuzumab.The irony of Humanisation. Part V

What have we been doing. So over the past week has been building up the story of alemtuzumab, the Worlds first Humanized antibody. However, it is the worst when it comes to anti-drug antibody responses. The paper today argues perhaps why. So if you are taking alemtuzumab it is a must-read. So you can sit down in you arm chair and have a good read. The paper is now online so click here , download...

Oncologising MS

We have been beating the combination-therapy drum for so long now we have become bored with the concept. Every time we apply for grants to test the concept, be it with pharma or via other traditional funding routes, we get pushback. Either our targets are questioned or the concept of combination therapies is challenged based on the scientific principles underlying the combination being proposed...

Whilst pharma data analysis says we can’t find anything, a critical eye fingers CD4 T cells as being important in disease break through after alemtuzumab.

Alemtuzumab. The irony of Humanisation. Part V… David Baker, Liaqat Ali, Gauri Saxena,  Gareth Pryce,  Meleri Jones,  Klaus Schmierer, Gavin Giovannoni, Sharmilee Gnanapavan,  Kathleen C. Munger,  Lawrence Samkoff, Andrew Goodman and  Angray S. Kang. The irony of humanization: Alemtuzumab the first, but one of the most immunogenic, humanized monoclonal antibodies Front. Immunol. doi: 10...

Alemtuzumab: The Irony of Humanization Part IV.

You asked us what have you lot been up to? DrAngry in Designer Dickie. He likes a bit of Couture. The next offering (Part V) was drawn using the Spring 2020 Colours In Part I we showed that alemtuzumab, which was the World’s first humanised antibody, designed to reduce the immunoogenicicty of the orginal rodent antibody, is probably the World’s most immunogenic therapeutic antibody...

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