CategoryLab Lessons

The solution for fatigue: getting tired (both of us!)

Nourbakhsh et al. have the honour of publishing the first article of 2021 that will change my practice. As bright and shiny as all the monoclonal antibodies on our treatment shelf are compared to the dusty and lacklustre drugs used to treat the symptoms of MS. However, the symptomatic treatments determine day-to-day life for many pwMS: fatigue, spasms, neuropathic pain, etc. For fatigue, the most...

This is BartsMS film week

In the COVID era the movie and cinema industry has taken a bit of a beating. You may have heard of Cannes and the Oscars In the East end of London the Canning Town‘ film festival is on and ProfK has been nominated for an “En-ree” (after Henry Croft) An En-ree Category: Best Animated Shorts We will be premiering them from Tomorrow CoI: This event was sponsored by Merck. But ProfK...

Swiss-cheese

Barts-MS rose-tinted-odometer: zero-stars What do you say when I colleague chastises you for stating the fact that MS is potentially a ‘preventable dementia’? This particular colleague was clear that there is no need to draw any parallels between MS and other neurodegenerative diseases because of the negative connations that the term dementia has. I had to remind him that MS ticks all...

Trial design can kill the development of treatments. Ideas from..Ibudilast

I bang on about this subject, over and over and over again about treatment failures. Animal studies are not the main reason for failure. It is trial design. This is the biggest threat. I am sorry to say that sometimes I get a pat on the head by the neuros and and get sent to the corner to shut-up. They say “You will respect my authority”..Now piss off! We are planning on doing trials...

For the people who can’t get vaccinated or don’t have it yet, an alternative approach. Stormchaser Trial

Bookmark this page you may want it. Are you worried that you have been exposed to someone carrying coronavirus? Why not consider taking part in a COVID-19 prevention clinical trial? If you think your job or living circumstances has exposed you to someone who has tested positive for coronavirus, you may be able to take part in a COVID-19 clinical research study. You will have access to no-cost...

Whats does this B cell depletion study mean?

You asked “However, some subsets of pro-inflammatory B-cells were increased, indicating that some B-cells can “promptly arise” after Ocrevus treatment and that “anti-CD20 treatment does not reconstitute a fully healthy immune system or re-establish immune tolerance in all patients, supporting the need for retreatment,” the team wrote. An explanation? The study showed what would be expected...

#MSCOVID19 Don’t be a COVIDiot when you get the vaccine

There is some concern that the effectiveness of the BioNTect vaccine based on news coming out of Israel. The UK took the rather, in my opinion, mad decision to extend the second dose from 3 to 12 weeks for the Pfizer vaccine to make it more like the Astrazeneca /Oxford vaccine. So now we need to know how much protecion you get from one Jab of vaccine But the stats on the News from Israel suggests...

Virus, virus where art thou hiding?

Barts-MS rose-tinted-odometer: ★★★★★★★★★★ Would you volunteer to participate in a clinical trial of an antiviral drug cocktail to suppress MS disease activity, in particular smouldering MS? There is reasonable evidence in the literature that HERVs (human endogenous retroviruses) may play a role in autoimmunity, in particular MS. HERVs are viruses (genetic code) that have been incorporated into...

What has my age got to do with having MS?

Barts-MS rose-tinted-odometer: ★★★ (some readers have asked for this feature to stay) How old are you? It depends. You may be aware that there can be a disconnect between your chronological or actual age and your biological age. As ageing or senescence is a biological process driven by metabolic, genomic and environmental factors you can see how there can be a disconnect between the two. As a...

Today I lost my virginity

Don’t understand the title…ask your dad:-). For may years I have been an virgin……an MRI virgin, but today I lost my cherry and I had a scan. I closed my eyes and lay there trying to empty my head and keep still as possible, but all I could do was hear the machine. I started thinking was this one a T1 or that one a T2…or the other meaning it needed abit of oil:-). Do...

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