CategoryLab Lessons

MS Vaccine

The development of COVID-19 and the rapid way that RNA vaccines have been developed means that you have a rapid way of developing vaccines against your viruses of choice. So which virus do you want to get rid off…The ones that cause warts Hope this doesn’t put you off your rice crispies this morning:-) Epstein Barr Virus? Well ProfGs wish is their command, maybe he can convince them...

Sod the #MSCOVID19 vaccine give me the MS trials

You can have loads of ideas but you can’t do all the science on the planet, but it is nice to see an idea come true. Since the COVID-19 pandemic arrived Now what do I mean Sod the COVID vaccine, well of course I dont mean don’t take it if you are offered it. But what is the vaccine going to do? Hopefully, it is going to stop you getting symptomaic infected so that you do not pass on...

A marker for active MS points at B cells

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis.DiSano KD, Gilli F, Pachner AR.Mult Scler J Exp Transl Clin. 2020 Dec 16;6(4):2055217320981396.  Background: Clinicians caring for patients with Multiple Sclerosis (MS) need improved biomarkers to aid them in disease management. Objective: We assessed the predictive value of the candidate biomarker...

How is your end-organ functioning?

Barts-MS rose-tinted-odometer: ★ My prediction or dream for 2021 is that smouldering MS will be accepted by the wider MS community as being the ‘real MS’ and that simply suppressing the immune response to what is causing MS, i.e. relapses and/or focal MRI activity, will be accepted as folly. What matters most to pwMS will be their end-organ, i.e. the size, reserve capacity and function of their...

What is your ACB?

ACB = anticholinergic burden Barts-MS rose-tinted-odometer: ★ “I had no idea oxybutynin and other anticholinergics affected cognition to such an extent” is the standard response I get when I discuss the impact of the most commonly prescribed drugs for MS-related bladder problems (urgency and frequency). The older the bladder drug the more likely it is to cross the blood-brain barrier and affect...

Unsteadiness

Barts-MS rose-tinted-odometer: ★★★★★ How many of you people who have MS (pwMS) have balance problems; i.e. when you stand and close your eyes or try and stand on one leg you tend to fall?  Since my accident, I have been having problems with balance. I first noticed it when I tried to stand on one leg and I would feel unsteady. When walking to and from the bathroom at night I tend to veer to one...

Mousey study to make ProfG happy….It’s all EBV or is it?

A christmas present for ProfG…It’s EBV….But am I BoJo and about to Steal the Crombo Joy away from him Márquez AC, Shanina I, Horwitz MS. Multiple Sclerosis-Like Symptoms in Mice Are Driven by Latent γHerpesvirus-68 Infected B Cells. Front Immunol. 2020 Nov 19;11:584297. Multiple sclerosis (MS) is caused by a combination of genetic and environmental factors. It is believed that...

If you have the Lumper’s you get the Splitters too. Can imaging spot the progressors

Diagnosis of Progressive Multiple Sclerosis From the Imaging PerspectiveA ReviewFilippi et al. JAMA Neurol 2020. doi:10.1001/jamaneurol.2020.4689 Importance  Although magnetic resonance imaging (MRI) is useful for monitoring disease dissemination in space and over time and excluding multiple sclerosis (MS) mimics, there has been less application of MRI to progressive MS, including...

Epidemic

Barts-MS rose-tinted-odometer: ★ Do you live in Scotland? Thes latest MS incidence (new cases) and prevalence (all cases) figures from the Scottish Highlands should make Scottish public health officials shiver.  In the Scottish Highlands, there are now over 18 people diagnosed with MS every year per 100,000 population with a total of 376 people with MS per 100,000 population. These figures...

Bring back the experts

Barts-MS rose-tinted-odometer: ★★ “I think the people of this country have had enough of experts”, Michael Gove, June 2016. Of the many positive things to come out of the COVID-19 pandemic and our response to it is the end of the era of denigrating the expert. Yes, expertise and in particular deep expertise really matters and that applies to the diagnosis and management of multiple...

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