CategoryLifestyle and self-management

Smoking Never too Late to Quit

Rodgers J, Friede T, Vonberg FW, Constantinescu CS, Coles A, Chataway J, Duddy M, Emsley H, Ford H, Fisniku L, Galea I, Harrower T, Hobart J, Huseyin H, Kipps CM, Marta M, McDonnell GV, McLean B, Pearson OR, Rog D, Schmierer K, Sharrack B, Straukiene A, Wilson HC, Ford DV, Middleton RM, Nicholas R; MS Register group. The impact of smoking cessation on multiple sclerosis disease progression. Brain...

Should we reclassify MS as a sleep disorder?

Barts-MS rose-tinted-odometer: ★★ (Dark blue sleepy Friday #00008B) The study below is another demonstration of how MS affects sleep.  Sleepiness, abnormal sleep timing, and poor sleep quality is just the tip of the iceberg. Two-thirds of subjects were in the extreme ranges in at least two sleep domains studied. Worryingly, markers of sleep disruption were associated with more depressive...

MS-Selfie

Educating/Empowering MS patients Every five minutes someone, somewhere in the world, is diagnosed with multiple sclerosis – joining the 2.8 million people already living with it. What they soon discover is MS is a fiendishly complex disease. No two people have the same disease course or symptoms – nor do they respond to drug treatments in a similar way. They also find – in the...

Is metformin a super-drug?

Barts-MS rose-tinted-odometer: ★★★★★ (skoda baby pink Wednesday #cca49a) Should we all be taking metformin? As you know metformin is being tested in a remyelination therapy trial in MS; it rejuvenates senescent oligodendrocyte precursors making them more likely to make myelin.  The biology of metformin is fascinating as it also activates NRF2 the master transcription factor for programmed cell...

Probiotics survey is inconclusive

As promised the following are the recent result from the probiotics survey. I think there are too few respondents to make any judgement on this data. Probiotics and microbiome are clearly hot topics and hence we will at some stage need to generate good evidence to make some sensible recommendations to pwMS. At the moment I don’t think there is enough evidence to recommend pwMS take...

Are you a potential faller?

Barts-MS rose-tinted-odometer: ★★ (A Green & Yellow Friday – Lime Green (#32CC32) & Lemon Glacier (#F4FF00)) The biggest risk of losing your independence is falling and long bone fractures of the lower limbs. PwMS are 6x more likely than the general population to fall and fracture a lower limb long bone. I currently have a patient of mine with PPMS in hospital with bilateral...

Probiotics: yes, no or maybe?

Barts-MS rose-tinted-odometer: ★★ (Black Friday, Friday the 13th #000000) The meta-analysis below of probiotics suggests they may help people with MS (pwMS). However, when you drill down into the details you will note that there were only four studies included in the meta-analysis with 213 actively treated subjects compared to 107 controls. Far too small to be confident of an effect. The problem...

Bowel Dysfunction in MS is Common

As the is more damage in the spinal cord then the innervation between the gut and central nervous sytem becomes damaged to and this may result in bowel dysfunction Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study.Alvino B, Arianna F, Assunta B, Antonio C, Emanuele D, Giorgia M, Leonardo S, Daniele S...

Are you feeling prematurely old?

Barts-MS rose-tinted-odometer: ★★ (Gray Thursday as in getting old Thursday #808080) As you are all aware ageing is a fact of life and is essential for evolution to do its job properly. Even bacteria and fungi age. Ageing is, therefore, a biological process and is driven by various biological pathways and networks controlled by our genes. It is well known that chronic inflammation results in...

Does MS exile you from the everyday of life?

Barts-MS rose-tinted-odometer: ★★★★★ (Sunday or Summer orange #f99f00) Exercise has emerged as a safe, effective, low-cost, non-pharmacological intervention for managing disability experienced by pwMS. Despite the evidence, it is the most under-prescribed and under-utilised disease-modifying therapy we have at our disposal.  Exercise promotes improvements in aerobic capacity, muscular strength...

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