CategorySymptoms and treatments

RUN SIZOMUS RUN!

Mama Always Said, Life Was a Box of Chocolates. You Never Know What You’re Gonna Get – Forrest Gump, 1994  A few years back Prof G, whilst talking about MS at a conference was approached by Takeda Pharmaceuticals on whether we would be interested in targeting plasma cells; probably one of the last frontiers in MS. The ideas started spinning from there. Roll forward a few years, after...

Thinking about switching.

Switching from fingolimod has an impact on ocrelizumab Signoriello E, Lus G, Bonavita S, Lanzillo R, Saccà F, Landi D, Frau J, Baroncini D, Zaffaroni M, Maniscalco GT, Curti E, Sartori A, Cepparulo S, Marfia GA, Nicoletti CG, Carotenuto A, Nociti V, Caleri F, Sormani MP, Signori A. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the...

Stuck in a loop

Starting certain MS drugs may get you stuck in a loop that you never bargained for when you started them in your early thirties or forties. The ability to stop taking drugs at an older age is something we more or less take for granted, especially if we have been disease free for ‘X’ many years. However, in the MS world things are never that simple or straightforward; there is...

Will the real slim-shady please stand up?

Vitamin D is one of the biggest confounders in MS clinical trials. It’s like a chess piece, where every move has an effect on the outcome. This latest piece of research from Romania studying the effect of Copaxone (immune modulator) versus prednisone (steroid) on circulating immune complexes (auto-antibodies) in RRMS, shows exactly this. The investigators found low serum levels of immune...

MS Octupus is hatching

The octupus is an incredibly intelligent mollusc and starts life as an egg. If you want to see an amazing film watch “My Octupus Teacher” its on Netflix (See trailer.) set in South Africa. Maybe it will be the last time you will eat one! I have seen the birth of this octupus (see below) It is a massive (90 x 60cm) bronze made in the East End of London by an amazing artist. I first saw...

Mind matters

New research from Brazil suggests that the act of walking when you have MS uses up greater cortical resources than if you don’t have MS; especially in the frontal and parietal cortical areas. Their hypothesis is that this increased activity is a compensatory response for the subcortical damage that occurs with MS. This is a plausible as majority of MS lesions occur in a periventricular...

Can’t Neuros just flipping Read!

This is one of those posts where I bring our profession into disrepute. The neuros are gods when they do something that works and yes I am not worthy when it comes to licking the bosses boots, but eventually you have to crack. I have been reporting year after year as a stocking filler for when ProfG or some other neuros posts something of interest. Therefore I have read a lot and you see this...

Doing the Hokey Cokey to work out what starts MS:-)

Sing to the Hokey Cokey. (Not sure (click here) it can be you exercise for the day:-). You put the dodgey ideas in, you throw the logic out, in out, in out, you shake it all about, you do the “Frontiers” con job (Appoint editors to get their mates to publish in a Froniers journal at $2-3,000 a time….Ker-ching, Ker-Ching) and flip-flop all around and thats what’s its all...

Why would you make a comic book about that?

Things neurologists don’t expect to hear during a consultation, example #327: “I’ve made a comic book about having MS, and you appear as a character on the first page! Can I send you a copy?” But that is exactly what I said to Prof K last time we met. And here is that first page: I know he doesn’t really look anything like that. I don’t have an enormous Mohican either. And more importantly, I...

B cell follicles and Salt in mice, but are mouse studies worthwhile, as they show CD20 depletion isn’t that important?

This one may get me into trouble, but it makes me disillusioned about the value of some animal work. I realise that I am becoming the grumpy old git. However, we have made the point that (a) B cells may be important targets for therapy in MS and (b) that mouse EAE is T cell mediated and doesn’t particularly respond to CD20. This is in our research area. It is important that we address...

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