CategorySymptoms and treatments

Guidelines for Managing Thyroid dysfunction

This post is for any health-professions who read the blog. This gives guidelines for managing thyroid problems notably after alemtuzumab 2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy. Muller I, Moran C, Lecumberri B, Decallonne B, Robertson N, Jones J, Dayan CM. Eur Thyroid J. 2019 Jul;8(4):173-185. Thyroid...

Is this the next treatment for MS…If you have psychosis?

We all have heard about BioRXiV (Bioarchive), where people can deposit their preprints before publication on a journal. Now there is not MedRXiv (Medarchive). All that needs to be done is link this up to Pubmed and we can cut out the middle man (publisher). A free archive that is open access and you get rid of the impact factor and the publishing mess in one easy swoop. What’s not to like...

WORMS for MS

This study has been sometime coming and was I think probably originally based on the idea that a worm infection can drive a TH2 (anti-inflammatory) from a TH1 (pro-inflammatory) response. I think there were a number of studies planned, but this study from Nottingham passed the finish line. In this study people were infected with the hookworm parasite and I guess became biobombs as the worms would...

Brain volume loss in MS

Cognition (thinking, memory and learning) is known to be affected in MS. This is more so in progressive MS. In a study last year, it was found that those with more structural damage to the brain at baseline were more likely to have cognitive issues. And more likely that not cognitive issues were encountered if the brain cortex was involved (the area comprised of the surface of the brain where...

HSCT guidelines. Have a read if interested

Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE). Sharrack B, Saccardi R, Alexander T, Badoglio M, Burman J, Farge D, Greco R, Jessop H, Kazmi M...

Diabetes drug to the rescue. Making old cells young again

As you get older you do not repair as well, compared to when you are younger. This has been known for some time and a few years ago Prof Franklinstein sewed mice together and determined that young macrophages could allow old mice to repair. So it is an obvious thing to look for the elixior of youth. In other studies a blood protein promoted youthful effects in nerves Metformin is a treatment...

Vitamin D in Mice

High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium As you know we have posted on this paper already and we were rather critical of the paper, because the refereeing was frankly rubbish. However what do we know? This study in mice has been picked as Editors choice in the journal Brain and it got a special mention in ECTRIMS2019. The home...

JCV index and the effect of DMTs

JCV STRATIFY (anti-JCV antibody) test has been utilized for more than decade to de-risk natalizumab treatment and other DMTs for risk of PML (Progressive Multifocal Leukoencephalopathy). Cases of PML have occurred predominantly in natalizumab, but less commonly with fingolimod (Gilenya), dimethylfumerate (Tecfidera) and rituximab. A high JCV antibody index value indicates that the risk of...

All for one and one for all

“All for one and one for all”- The Musketeers FACTS Fact 1 – Siponimod (Novartis Pharmaceuticals) trialed for SPMS, but the FDA label sits as Clinically isolated syndrome (the first clinical episode), Relapsing-remitting MS, and active Secondary progressive MS. Fact 2 – Ocrelizumab (Genentech, Roche Pharmaceuticals) trialed for RRMS/PPMS; the latter has been shown to be...

Remyelinating agent. Is this the antidote to shrinking lips

A modified flavonoid accelerates oligodendrocyte maturation and functional remyelination.Su W, Matsumoto S, Banine F, Srivastava T, Dean J, Foster S, Pham P, Hammond B, Peters A, Girish KS, Rangappa KS, Basappa, Jose J, Hennebold JD, Murphy MJ, Bennett-Toomey J, Back SA, Sherman LS. Glia. 2019 Sep 6. doi: 10.1002/glia.23715. [Epub ahead of print] Myelination delay and remyelination failure...

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