CategorySymptoms and treatments

Is you current interferon beta treatment any benefit against #MSCOVID19

Interferons in the Therapy of Severe Coronavirus Infections: A Critical Analysis and Recollection of a Forgotten Therapeutic Regimen with Interferon Beta.Brzoska J, von Eick H, Hündgen M.Drug Res (Stuttg). 2020 May 22. doi: 10.1055/a-1170-4395. Online ahead of print.PMID: 32443163 There is a question about whether interferon B can be used for the treatment of COVID-19. This is because interferons...

#MSCOVID19 It’s not all good news for anti-CD20

ProfG has written about the the effect of continous B cell depletion and the the influence of B cell depletion. However, this posts asked if continous B cell depletion can put you at risk of catching SARS-CoV-2 virus. Although B cells are important in fighting off bacteria, there is a small increased risk of catching some viral infections (Hauser et al. 2019). CD20 is expressed by the B cells...

#MSCOVID19. Beta interferon part of the COVID cock tail.

This study suggests that a cocktail of antivirals containing beta interferon may havesome value in controling COVID-19. In this study anti-virals were administered a few days after symptom onset. But in MS people will have this onboard before virus appears. SO the question is does this stop SARS-Cov-2 infection. I have to say I think the answer is no, because I am sure I have seen cases of...

Dr Angry crank up the Machine…another project.

DrAngry is a bit of a boffin and has been making anti-drug antibody assays. We have a paper about to arrive on the anti-drug antibody (ADA) response of alemtuzumab. It is the “poster-girl/boy” when it comes to ADA as it causes then in so many people. It busts the myth that making a humanised antibody makes things less immunogenic (rejected by the immune system). It can cause about 60%...

Can I see your #MSCOVID19 paper?

I few days ago I mentioned not wanting to review someones COVID-19 and MS review, because it was missing published information and so I did not want to write their review. I submitted my constructive review of the paper for the authors benefit and then bowed out of the referering process. You said that I should put my review online. However, that review was a critique of their paper, not a review...

Chemical CCSVI…It’s back

So I ask were is VV when you need him. For the new readers, he was the nemesis of this blog, who used to give us a good kicking for not giving the idea about CCSVI=blocked veins that we should have. VV used to put arguments against our arguments and what would he think of this work done in animals. So if we asked “Is this Chemical Angioplasty the next great thing? Would VV give the answer...

When is the next Split of MS

Many years ago optico-spinal MS was called Devics MS and now it is called Neuromyelitis Optica. Here many people make antibodies to aquaporin 4, but a few people also make antibodies to myelin oligodendrocyte glycoprotein (MOG). In this study they report that some people who are diagnosed with MS, respond to plasma exchange. Here you separate the blood plasma (PLEX) from the cells, you return the...

OK Neurologists, this is not about COVID but Read and Take Note..Yep Time Really is Brain and it’s not yours that you maybe wasting. Make sure you diagnose correctly and treat early

I was once at an MS meeting and a collaegue from a country who are known for being blunt was speaking to someone who had been using an injectable and was having injection site reactions. MD2 and I were shocked when we heard “It is rubbish, throw it in the bin”. ProfG has been crusading for the Time is Brain movement, arguing that you should be diagnosed as quick as possible, and...

The COVID19 brain

Letter by British Rhinological Society and Ear, Nose & Throat UK Although severe acute respiratory syndrome (SARS) has been the hallmark of severe COVID19 infection, anosmia (lack of smell) and hypogeusia (the reduced ability to taste), headaches/dizziness have also been reported. Is COVID19 neurotropic? We don’t have hard data to support/refute this beyond history from those so far...

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