CategorySymptoms and treatments

OK Neurologists, this is not about COVID but Read and Take Note..Yep Time Really is Brain and it’s not yours that you maybe wasting. Make sure you diagnose correctly and treat early

I was once at an MS meeting and a collaegue from a country who are known for being blunt was speaking to someone who had been using an injectable and was having injection site reactions. MD2 and I were shocked when we heard “It is rubbish, throw it in the bin”. ProfG has been crusading for the Time is Brain movement, arguing that you should be diagnosed as quick as possible, and...

The COVID19 brain

Letter by British Rhinological Society and Ear, Nose & Throat UK Although severe acute respiratory syndrome (SARS) has been the hallmark of severe COVID19 infection, anosmia (lack of smell) and hypogeusia (the reduced ability to taste), headaches/dizziness have also been reported. Is COVID19 neurotropic? We don’t have hard data to support/refute this beyond history from those so far...

Natalizumab and the Lung

The ABN is saying natlaizumab is OK, but have they thought about the science? ProfG has asked if there is a literature on neurotrophism from coronavirus? If there is would you inhibit surveillance. This is not unknown for this type of virus…food- for thought. But the main route of entry of COVID-19 into cells is via the ACE-2 receptor. This is very low in the CNS in humans. source Brainseq...

Drug induced lymphopenia and evidence of infection

I will just put this up without to much discussion but it suggests that the lymphopenia associated with dimethyl fumarate and fingolimod are not really linked to noticably higher infection rates in the real world setting. This view has been repeated for many other agents that blood cell numbers do not appear to correlate with disease activity. Now it may be if you drill down on specific subsets...

How Does Rituximab Work

Clustering for the kill Cluster of differentiation 20 (CD20) is a membrane protein that defines most B cell populations and is the target of therapeutic antibodies to treat malignancies and autoimmune disorders. The structure of CD20 bound to the antibody rituximab that activates the complement system (a cascade of enzymes that punch holes in their target to kill them) to kill B cells. CD20 forms...

#COVIDMS IL-6R. Pharma to the Rescue?

Neuromyelitis optica used to be part of the MS disease spectrum, where people have notably spinal cord and optic nerve involvement. With the finding that this disease is associated with antibodies against brain rptoeins and that is responds differntly to some MS drugs..it has become a new syndrome. As such it is getting its own treatments. These include blocking a complement component, a...

Eat SH1 MouseDoc, it is the microbiome! Is this a new supplement to try?

About time we posted on something other than COVID-F-ing-19, so whilst we are all hunting to zinc, panty liners, gloves, etc, something else to add to the shopping list…Only joking. I admit it, I have not been following the microbiome as the major hope in MS, as I see it as a modifier, at best. At worst…Em. Whilst I don’t want to be a lemming rooting through your SH1 to find the...

CAR-T cell therapy and PML

CAR-T is a type of therapy where you get T cells to recognse a target by introducing the antigen-binding bit of antibodies attached to a T cell activating bit. One approach s to make them CD19 specific so they can root out and kill any CD19 expressing B cell. It could scrub the brain clean of CD19 B cells and I have heard one opinion leader from US saying they planned to use CAR-T cells in MS. It...

Administration of subcutaneous interferon Reducing flu like symptoms

This is not a post on Covid-19, but a post for the readers who use the beta interferons you may be interested in this. I makeno comment I’m not a neuro Administration of subcutaneous interferon beta 1a in the evening: data from RELIEF study. Patti F, Zimatore GB, Brescia Morra V, Aguglia U, Bossio RB, Marziolo R, Valentino P, Chisari CG, Capacchione A, Zappia M; RELIEF Study Group.J Neurol...

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