CategorySymptoms and treatments

Trial design can kill the development of treatments. Ideas from..Ibudilast

I bang on about this subject, over and over and over again about treatment failures. Animal studies are not the main reason for failure. It is trial design. This is the biggest threat. I am sorry to say that sometimes I get a pat on the head by the neuros and and get sent to the corner to shut-up. They say “You will respect my authority”..Now piss off! We are planning on doing trials...

For the people who can’t get vaccinated or don’t have it yet, an alternative approach. Stormchaser Trial

Bookmark this page you may want it. Are you worried that you have been exposed to someone carrying coronavirus? Why not consider taking part in a COVID-19 prevention clinical trial? If you think your job or living circumstances has exposed you to someone who has tested positive for coronavirus, you may be able to take part in a COVID-19 clinical research study. You will have access to no-cost...

Cyclophosphamide kills immune cells dead

Most immunologists are well versed in the use of cyclophosphamide for all sorts of non-MS related inflammatory disorders; it is for all intents and purposes a ‘Domestos’. It’s dirt cheap – one 500mg vial costs £9.66 on the NHS, and is often only used as induction therapy with a few doses at time. It’s ‘Domestos’ action comes from its apoptosis (or cell...

Sod the #MSCOVID19 vaccine give me the MS trials

You can have loads of ideas but you can’t do all the science on the planet, but it is nice to see an idea come true. Since the COVID-19 pandemic arrived Now what do I mean Sod the COVID vaccine, well of course I dont mean don’t take it if you are offered it. But what is the vaccine going to do? Hopefully, it is going to stop you getting symptomaic infected so that you do not pass on...

New study testing an upper limb rehab tool – get involved!

The Barts MS team are running a study, investigating whether a new hand and arm activity called “Under & Over” can improve upper limb function for people with MS. The study is titled: “Under & Over: A controlled study to develop an upper limb rehabilitation tool for people with Multiple Sclerosis.”  This study is now recruiting – find out more information on the...

Polypharmacy in MS

In this blog, our overarching goal has been to keep our readers up to date with the latest research in MS. One of the things I’ve noted in this time is that the vast wealth information out there isn’t insurmountable – you only need to select the ones that appeal to you, or are relevant to your practice. Information/’knowledge’ is probably the last bastion of...

This is not a drug, a leaf

Last year should probably be marked as the year of the alcohol, the year before that, Vape stores and Cannabis extracts. I remember being offered ‘Leef’ based skin care products at the airport even. Not surprisingly, given the current climes, there is even talk that COVID19 may have provided the impetus for legalization of cannabis as part of a campaign to plug the current 2tn hole in...

Delaying Ocrelizumab for up to 12 weeks

The ocrelizumab dosing is done every twenty four weeks. I have suggested that this may be overkill and is done more than is needed. However delaying treatment without evidence is not sensible. We have suggested doing a trial. Based on the phase II trial it looks like it takes about 60 weeks for the B cells to recover so for some dosing every 24 weeks maybe too much. Is it safe.? During the COVID...

Food for thought

The gastrointestinal tract (image taken from The Conversation) You may not think much of your gut, which in most peoples mind is simply one giant hosepipe from start to finish. But, this week after eating something quite oily, I was painfully made aware of my gut’s existence. The gut from an energy and metabolic point of view is a very important organ, and without it you would simply be a...

Gratitude

Barts-MS rose-tinted-odometer: ★★★★★ A problem in modern medical practice is the assumption that there is a pill for everything. The one eye-opener for me after my recent trauma has been how easy it is for medics to reach for the prescription pad. When I was first discharged from hospital I was on 14 different medications. About half of the medications were prescribed to manage or prevent the...

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