CategorySymptoms and treatments

Science Fiction: Vitamin D

Failed vitamin D trial..Failed to infrom:-( ProfG has done a post on medical fiction. It is perhaps approriate to do a post on science fiction. As you know scientists are like sheep and they herd together and follow one and other. They stick close to the “dogma machine” and follow trends because, this is where money gets put. I have gone on the record of discussing a few. Some I have...

Alemtuzumab.The irony of Humanisation. Part V

What have we been doing. So over the past week has been building up the story of alemtuzumab, the Worlds first Humanized antibody. However, it is the worst when it comes to anti-drug antibody responses. The paper today argues perhaps why. So if you are taking alemtuzumab it is a must-read. So you can sit down in you arm chair and have a good read. The paper is now online so click here , download...

Alemtuzumab: The Irony of Humanization Part IV.

You asked us what have you lot been up to? DrAngry in Designer Dickie. He likes a bit of Couture. The next offering (Part V) was drawn using the Spring 2020 Colours In Part I we showed that alemtuzumab, which was the World’s first humanised antibody, designed to reduce the immunoogenicicty of the orginal rodent antibody, is probably the World’s most immunogenic therapeutic antibody...

Alemtuzumab:The Irony of Humanization Part I & II

What’s this all about? I wonder if we will get the Pulitzer prize for this? I suspect we will get a lot of grief. You have said what have you been up to? I have asked you to tweet. #isitoK that Pharma do trials on disabled people, but do not publish the results if they are not advantageous to the company? Today, we move from ocrelizumab and Roche, back to alemtuzumab and Sanofi-Genzyme...

The case for more trials with ocrelizumab. Can we use reduced dosing of ocrelizumab?-Part II

QR code of paper The publication process is broken. We are all desperate to get our papers in high-impact factor journals, because we are being judged by what we publish. The journals know this and either have a set of reviewers that can ask the earth before the work is published and then they charge you for the pleasure of publishing. These journals get so many papers they are picky and can ask...

The case for more trials with ocrelizumab. Can we use reduced dosing of ocrelizumab?-Part I

#isitoK that Pharma do trials on disabled people, but do not publish the results if they are not advantaveous to the company? If you can PLEASE, PLEASE. PLEASE go to the website of the journal and Tweet the link. It will help get this seen in search engines and help make the content known. MedRXiv Ocrelizumab is currently doing very well in sales and is approved for 6 monthly dosing. B cells are...

Clinical trials vs. real-world data in MS

We probably don’t really require a study to tell us that those participating in clinical trials are not exactly the same as the general population that may take a particular treatment – we already know this. However, when it comes to MS drugs it is worth noting what the differences between the two populations are. According to Rojas et al., upon reviewing 18 clinical trials and 73...

Adenovirus infection after HSCT

Adenovirus is pretty common in the general population, responsible for the common cold, sore throat, bronchitis, diarrhea and conjunctivitis. It is harmless in most instances and like the herpes virus, most of us remain latently infected. During periods of immunosupression, however, the adenovirus can reactivate causing untoward trouble. The latter can range anywhere from organ-specific...

To botox or not to botox

That is the question: Whether ’tis nobler in mind to sufferThe slings and arrows of bladder instability,Or to take arms against a sea of troubles,And by opposing end them? –Shakespeare a’la NDG Bladder botox treatment If you suffer from bladder dysfunction, ask yourself why put with the dry mouth from Vesicare and Co., when a few injections of botox per year will do? It works...

High Dose Biotin study fails to reach the mark

High dose biotin has led to many people to be chomping on loads of low dose biotin pills. But dooes it work? According to this report not very well. High-dose biotin in progressive multiple sclerosis: A prospective study of 178 patients in routine clinical practice. Couloume L, Barbin L, Leray E, Wiertlewski S, Le Page E, Kerbrat A, Ory S, Le Port D, Edan G, Laplaud DA, Michel L.Mult Scler...

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