CategorySymptoms and treatments

Blood starved MS

There is mounting evidence that the brain blood supply is affected in MS. Perfusion MRI studies have found that blood flow is globally impaired in the normal appearing brain of both relapsing and progressive forms of MS. Interestingly, there appears to be an association between this and cognitive (memory and intelligence) dysfunction in MS. In animal models, chronic hypoperfusion of the brain...

Alemtuzumab rescue therapy for rebound after stopping natalizumab

Natalizumab is an effective strategy for achieving disease control in those with highly-active MS, but owing to the risk of progressive multifocal leucoencephalopathy (PML), often needs to be de-escalated. However, discontinuation of natalizumab therapy is not without its own risks; the biggest risk being rebound activity, which rarely may be a flare beyond that of pre-treatment disease activity...

MS DMTs that hit the regenerative note

Santiago Ramon y Cajal Who said that the brain doesn’t regenerate? Well, it was the neuroscience Dogma as far back as philosophy. But, not in certain quarters; Santiago Ramon y Cajal (1852-1934), widely believed to be the father of modern neuroscience in his treatise ‘Degeneration and Regeneration of the Nervous System’, alludes to the potential of the brain to regenerate in the...

MS as an indication for HSCT – an American perspective

Dr Luddites As HSCT’s (Haemopoeitic Stem Cell Transplantation) popularity grows, the need for guidance and regulation grows in equal measure. Which is why in 2015, the American Society for Blood and Bone Marrow Transplantation (ASBMT) designated MS as a ‘developmental’ indication for HSCT, but has since reconsidered its position.It must be remembered that HSCT is a technology...

The cause of Progressive MS is here. Its Grey matter Directed T cells… Really?

What is the difference between relapsing and progressive MS. This new work from one of the number one science comics now tells us that it is due to immune cells responding to a grey matter protein called beta synuclein Nature | Published: 20 February 2019 β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration Dmitri Lodygin et al. ,  The grey matter is a central target of...

MS-STAT2 – Simvastatin for Secondary Progressive MS

Thank you to Prof. G, MouseDoctor and the Barts MS team for letting us reach out to you about the MS-STAT2 study! Are you interested in taking part? We would love to have you involved! Follow the link for more details and to register your interest: www.ms-stat2.info MS-STAT2 – What is it? The MS-STAT2 study is a 3 year clinical trial testing whether high dose simvastatin can slow down the rate of...

Spanner in the works for intrathecal rituximab

Figure: To-and-fro bi-directionality of CSF flow in the brainBy © Nevit Dilmen, CC BY-SA 3.0 I get a sinking feeling in the pit of my stomach when I read this article. Starting out in science, one is considered smart when following the trends of the populist. As a seasoned scientist, when one continues to work in this way, one is just not being too clever. I am not being disparaging of those who...

More B cell stuff. Don’t deal with the B cells…Don’t deal with disease?

Longitudinally persistent cerebrospinal fluid B-cells can resist treatment in multiple sclerosis.Greenfield AL, Dandekar R, Ramesh A, Eggers EL, Wu H, Laurent S, Harkin W, Pierson NS, Weber MS, Henry RG, Bischof A, Cree BA, Hauser SL, Wilson MR, von Büdingen HC. JCI Insight. 2019 Feb 12. pii: 126599. doi: 10.1172/jci.insight.126599. [Epub ahead of print] B-cells are key contributors to...

To B or Not to B..that’s is ProfG’s Atrophy Question

Effect of disease-modifying therapies on subcortical gray matter atrophy in multiple sclerosis.Sotirchos ES, Gonzalez-Caldito N, Dewey BE, Fitzgerald KC, Glaister J, Filippatou A, Ogbuokiri E, Feldman S, Kwakyi O, Risher H, Crainiceanu C, Pham DL, Van Zijl PC, Mowry EM, Reich DS, Prince JL, Calabresi PA, Saidha S. Mult Scler. 2019 Feb 11:1352458519826364. BACKGROUND:The effects of disease...

How Does Cladribine Work?

Here is a new offering from the CLAD lads :-), and follows on from the information that we got from the European Medicines Agency and from stuff in the public domain. This is not a pharma supported piece of work and they may have different views of how cladribine works or how they want to portray how they think this works, but as usual for us, it contains ideas of the unknown. Things we and...

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