CategoryTrials

The B-cell line up

Figure: Anti-CD20s (A) rituximab (yellow), (B) ocrelizumab (red), (C) ofatumumb (green), (D) ublituximab (brown) The B-cell line up for MS now reads: rituximab, ocrelizumab, ofatumumab, and ublituximab. A fair number of you believe that these four treatments embody some magical powers, but I am about to demystify some of these beliefs and explain the science behind them. The three main take away...

For the people who can’t get vaccinated or don’t have it yet, an alternative approach. Stormchaser Trial

Bookmark this page you may want it. Are you worried that you have been exposed to someone carrying coronavirus? Why not consider taking part in a COVID-19 prevention clinical trial? If you think your job or living circumstances has exposed you to someone who has tested positive for coronavirus, you may be able to take part in a COVID-19 clinical research study. You will have access to no-cost...

Cyclophosphamide kills immune cells dead

Most immunologists are well versed in the use of cyclophosphamide for all sorts of non-MS related inflammatory disorders; it is for all intents and purposes a ‘Domestos’. It’s dirt cheap – one 500mg vial costs £9.66 on the NHS, and is often only used as induction therapy with a few doses at time. It’s ‘Domestos’ action comes from its apoptosis (or cell...

New study testing an upper limb rehab tool – get involved!

The Barts MS team are running a study, investigating whether a new hand and arm activity called “Under & Over” can improve upper limb function for people with MS. The study is titled: “Under & Over: A controlled study to develop an upper limb rehabilitation tool for people with Multiple Sclerosis.”  This study is now recruiting – find out more information on the...

Delaying Ocrelizumab for up to 12 weeks

The ocrelizumab dosing is done every twenty four weeks. I have suggested that this may be overkill and is done more than is needed. However delaying treatment without evidence is not sensible. We have suggested doing a trial. Based on the phase II trial it looks like it takes about 60 weeks for the B cells to recover so for some dosing every 24 weeks maybe too much. Is it safe.? During the COVID...

Talk the talk…walk the walk

I took this figure from a paper that has little to do with the point I’m going to make here today. After having done this for a few years I hope I have earnt the right to speak my mind? Figure: Confirmed disability progression EDSS from the Avonex, Steroids, Azathioprine (AZA) study: one-third of patients shows relatively stable disease over time (taken from Berger T et al. Factors...

ChariotMS is on a roll…

I’ve been neglecting my blogging duties, but I have an excuse, which is that I had the team and myself on ‘slogging’ duties to get ChariotMS underway:-) ChariotMS is an ‘investigator-led’ trial, and that really means doing all related jobs yourself, from protocol writing to participant-information & consent sheets, case report forms, database, statistics...

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