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Q&A March

Today is Saint David’s day and I should be showing a picture of a bunch of daffodils (National Flower of Wales, in addition to the Leek), but instead you get a bunch of tulips for MsMouse

If you want to ask a question this is the place for you.

Latest stories

Overdosing, does this happen with fingolimod?

Overdosing is a current theme in MS treatment and in the era of COVID-19 attention has focus on whether extended dosing intervals could be used. Fingolimod is a once a day treatment but it has a long half-life of about 6-9 days meaning that it take 6-9 days for half the drug to disappear. So do you need to treat every day, it looks like the answer is no, but as ever we need a study . Clinical...

Ozanimod How does it work? Have we got a real clue?

Last week I wrote a post about how pharma may report on the next Cladrimod (cladribine or ozanimod/posenimod) study in “Dr Dooley will be happy that their uncited work from 2016 has been repeated….MS drugs affect memory B cells!”. In that post I made a prediction on how the lymphocyte subset data would be reported from the next MS drug so that the potential for memory B cell depletion...

Q&A August 2020

For those reading on 1 August. Happy Yorkshire Day

Gods Own Country

You know the the drill if you have a question unrelated to the threads. This is the place for you

Ocrelizumab inhibts vaccine responses

Ocrelizumab blunts the vaccination response this is shown in a trial if you want to read about it straight from the Horses mouth you can read below but it is behind a pay wall, if you want to see what was shown you can see it for free here. Baker D, Roberts CA, Pryce G, et al. COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases [published online ahead of print, 2020...

How to control temperature-sensitivity of nerve function

You may know that symptoms can get worse when you are too hot and this is because temperature can affect how nerves function. We have been looking into the reasons behind this and can see a way to potentientially reduce this Mark Baker Mechanism of sodium ion movement in optic nerve axons and implications for MS Energy deficit in neurons and axons is part of the zeitgeist of present-day MS...

Specificity of oligoclonal bands…Viruses?

Recombinant antibodies derived from laser captured single plasma cells of multiple sclerosis brain identified phage peptides which may be used as tools for characterizing intrathecal IgG response.Kennedy PGE, Graner MW, Walker D, Pointon T, Fringuello A, Yu X.J Neuroimmunol.2020 Jul 14;347:577319. doi: 10.1016/j.jneuroim.2020.577319. Online ahead of print. Oligoclonal bands and...

Dr Dooley will be happy that their uncited work from 2016 has been repeated….MS drugs affect memory B cells!

Part of the scientific process is repetition, but at some point in time you need to believe it and move one. This study is Open access and so you can read it, but it is further supportive evidence of the memory B cell hypothesis Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis.Baker D, Marta M, Pryce G, Giovannoni G, Schmierer K. EBioMedicine. 2017;...

Swallowing difficulties in MS

Swallowing difficulty or dysphagia occurs in a third of MS cases. Aside from the discomfort, it is dangerous for small bits of food to go down the wrong way into the lungs rather than in to the gullet. The latter can lead to chest infections (termed aspiration pneumonia), and is the leading cause of death in neurodegenerative conditions including MS. Early review of swallowing by Speech and...

Ker ching

ProfG has been asking questions about the prescribing habits of his colleagues and asks why alemtuzumab and HSCT are not being used by some. I wonder if the other end of the spectrum will be questioned and the use of lower efficacy agents. This is going strong Rome BN, Tessema FA, Kesselheim AS. US Spending Associated With Transition From Daily to 3-Times-Weekly Glatiramer Acetate [published...

Remyelination. Is this war amongst scientists?

Remyelination is a hot topic In the paper below they say “The view that differentiation of OPC into mature myelinating oligodendrocytes is required for successful remyelination in humans has been challenged recently. Measuring the integration of 14C derived from nuclear testing into DNA of oligodendroglial lineage cells Yeung et al. suggest that pre-existing oligodendrocytes and not...

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