Today is Saint David’s day and I should be showing a picture of a bunch of daffodils (National Flower of Wales, in addition to the Leek), but instead you get a bunch of tulips for MsMouse
If you want to ask a question this is the place for you.
Today is Saint David’s day and I should be showing a picture of a bunch of daffodils (National Flower of Wales, in addition to the Leek), but instead you get a bunch of tulips for MsMouse
If you want to ask a question this is the place for you.
COVID-19 in Multiple Sclerosis Patients and Risk Factors for Severe InfectionChaudhry, F., Bulka, H., Rathnam, A. S., Said, O. M., Lin, J., Lorigan, H., Bernitsas, E., Rube, J., Korzeniewski, S. J., Memon, A. B., Levy, P. D., Javed, A., Lisak, R., Cerghet, M.10.1101/2020.05.27.20114827 — Posted: 2020-05-29 Wow this figure is a bit vivid, but this follows the same pattern we are seeing over...
You can read….best wishes Efficacy and safety of interferon beta-1a in treatment of severe COVID-19: A randomized clinical trialDavoudi-Monfared, E., Rahmani, H., Khalili, H., Hajiabdolbaghi, M., Salehi, M., Abbasian, L., Kazemzadeh, H., Yekaninejad, M. S.10.1101/2020.05.28.20116467 — Posted: 2020-05-30 Objectives: To the best of our knowledge, there is no published study regarding use of...
Today is World MS Day 2020 and its theme is ‘connections’. MS Connections are about building community connection, self-connection and connections to quality care. The event is coordinated by the MSIF, who want to challenge social barriers that leave pwMS feeling lonely and socially isolated. Together, they are advocating for better services and are celebrating support networks. Another action...
I am trying something new instead of blogging, i.e. a podcast and a vlog. This week I cover some initial thoughts on how COVID-19 has affected MS Services and potentially MS research.
Gavin Giovannoni · #COVIDMS Friday #11 lockdown
CoI: multiple
To get a vaccine response for COVID-19 we need antibodies but we also need T cells. CD4 T cells help macrophages and B cells and others to do their stuff. CD8 T cells are the main anti-viral cells. So studies in people infected with COVID show a clear anti-COVID response and people treated with novel COVID-19 vaccines show antibody and T cell responses (Zhu et al. Lancet. 2020 May 22:S0140...
Since the COVID-19 story broke we have been focusing on the immune system, because after all the immune system will ultimately get rid of the virus. We have made the point that many MS-DMT may not grossly inhibit the cells responsible for the anti-viral response and so MS-DMT may not stop you responding sufficiently to the SARS-CoV-2 virus. More recently we have been suggesting that a central...
The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.David Baker, Sandra Amor, Angray S. Kang, Klaus Schmierer, Gavin GiovannoniMult Scler Relat Disord. 2020 May 12 : 102174. doi: 10.1016/j.msard.2020.102174 [Epub ahead of print]. This review has been type set and still not on pubmed. Here is the...
So yesterday we went through the process of how you can kickstart the immune response to target a viral response and looked at efforts to treat COVID-19. I asked if this could be applied to PML and in conclusion said NDG had done just that already. This was not in MS but in people who had low lymphocyte levels who had got PML. If you can remember from yesterday immune check point inhibitors. One...
Because cladribine and alemtuzumab are classified as immune reconstitution therapies (IRTs), and probably work in a similar way, they are tarnished with the same brush. However, cladribine’s immune depletion and reconstitution, and adverse event profile are very different to alemtuzumab’s and therefore cladribine should be considered on its own when weighing up the risks and benefits of...
The Space programme gave us a man on the moon , but in the process of that a lot of innovation was developed…like the Space Pen that I carry that writes upside down and underwater. Others include Artificial limbs. …Insulin pump. …DustBusters. …Shock absorbers for buildings. …Solar cells……Cold-Weather Wearables. …Foil Blankets. …Scratch...