TagB cells

Are your B cells rogue in multiple sclerosis?

The hallmark of MS is the presence of oligoclonal bands/antibodies in the spinal fluid (if you’re interested in knowing if you’re positive speak to your neurologist). Understanding, what types of antibodies these are and what they’re target is a growing field in MS. In this latest piece, a group in Norway have found that some individuals have antigen presenting cells (APCs)...

The take on BTK inhibitors: AAN 2021 has the answers

The scientific sessions at AAN 2021 were pretty devoid of exciting new developments (not surprising given COVID19), but did present updates on the use of BTK (Bruton’s Tyrosine Kinase) inhibitors in multiple sclerosis (MS). For those of you who hearing this term for the first time today, BTK inhibitors target both B cells in the periphery and resident microglia in the brain (see slide...

Is it B and/or T cells and which ones?

Can studying the pathology of MS and animal models of MS teach us about the cell types driving MS? Professor Lassmann is the doyen of multiple sclerosis pathology. He makes two very important points in this review. EAE the experimental model of MS is not MS. Interestingly, most EAE models are driven by CD4+ T-cells, which is very relevant to the second point he makes. Does this mean we should not...

DMF inhibiting B cells numbers

  Times are a changing folks.  Not a year ago the same type of phenotpying data was reported in the blood of people treated with DMF.  The focus has now changed, guess where. B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate. Høglund RA, Polak J, Vartdal F, Holmøy T, Lossius A. Mult Scler Relat Disord. 2018 Sep 6;26:90-95...

Memory B cells are there to help CD4 T cells

Memory B Cells present antigen to CD4 T cells in multiple sclerosis, so T cells are on top of the pile and B cells are there to help the baddie T cells. Therefore, the status quo is maintained and everything is super. However, has the latest autoantigen in MS been found? Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis. Jelcic I , Al Nimer F , Wang J ...

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