TagEBV

Curing MS

Barts-MS rose-tinted-odometer: ★★★★★ I have been asked many times if we can cure someone who has MS. I have tried to explain what an MS cure may look like many times on this blog and have actually published articles defending the definition.  I explained in a previous post that you may be cured of your MS, but still, have worsening or progressive disease. The difference between progressive...

On being EBV-negative and having MS

Barts-MS rose-tinted-odometer: ★★★★★ I have been diagnosed with MS and I am Epstein Barr Virus (EBV) negative. Therefore, EBV is not the cause of MS. Correct? I wish it was that simple.  Firstly, no laboratory test is 100% sensitive and specific. In other words, some people who have negative standard EBV serology may still have the virus, i.e. a false negative result, and some people who have a...

Eight Swallows

Barts-MS rose-tinted-odometer: ★★★★★ How many swallows make a summer? Is eight enough?  If MS is caused by EBV you would expect there to be clusters of MS potentially linked to a specific subtype of the virus. The best-studied MS cluster is the one from Fjelsø, a small village of 74 families in rural Denmark, where eight people closely linked to each other all developed MS within 13 years of each...

What is the most exciting MS research on the horizon?

I was asked about which paper I have written or co-written that has or will have the most impact in the field of MS. There is little doubt that it is our report of our 2017 workshop on “EBV Infection and MS Prevention”. This report (see below) was the catalyst for creating the Preventive Neurology Unit (PNU), which is embedded in the Wolfson Institute of Preventive Medicine. The...

Virus, virus where art thou hiding?

Barts-MS rose-tinted-odometer: ★★★★★★★★★★ Would you volunteer to participate in a clinical trial of an antiviral drug cocktail to suppress MS disease activity, in particular smouldering MS? There is reasonable evidence in the literature that HERVs (human endogenous retroviruses) may play a role in autoimmunity, in particular MS. HERVs are viruses (genetic code) that have been incorporated into...

#BlackSwan: anecdotal evidence we can’t ignore

Barts-MS rose-tinted-odometer: ★★★★★ What is a black swan event?  “The black swan theory or theory of black swan events is a metaphor that describes an event that comes as a surprise, has a major effect, and is often inappropriately rationalised after the fact with the benefit of hindsight”. (Source Wikipedia) The case study below is another example of a mounting number of case studies of...

#MSCOVID19 info wars

It is one thing calling for scientists to turbocharge the development of a coronavirus vaccine but quite another to get the population to have the vaccine. The anti-vaxxers are organising rapidly and have started circulating content with false information to achieve their aims. The movie plandemic is one example and is covered in a very good article in the New York Times today.   The primary...

EBV or not

The umpteenth study on causality means very little if it is not scientifically plausible. This is core science, and it’s what real scientists work on. EBV infection has long been strong contender for the development of MS. But, how strong is this link? What does having had EBV as a teenager do to your biological makeup (i.e. endophenotype)? In a first study of its kind the Swedish group...

EBV and MS

This is not about coronavirus. Epstein-Barr Virus is an(other) extremely common virus which has infected the vast majority of people (~95%) by their late 20s. Unlike coronavirus, EBV has co-evolved with humans and the observation that it is so ubiquitous suggests that it actually may confer some kind of evolutionary benefit, e.g. by enhancing the host’s ability to respond to novel...

HSCT is shifting the Bell curve

Barts-MS rose-tinted-odometer  ★ ★ ★ The good news is that the use of autologous HSCT to treat autoimmune diseases rose (by 19%) in the European Bone Marrow Transplant registry in 2018. Importantly, this rise was predominantly due to HSCT treatment for multiple sclerosis. This would indicate that at least at the very right of the bell curve there is increasing use of a more aggressive...

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