Tagmicroglia

My predictions for 2022 foresee choppy waters for Clemastine

Figure: Myelin formation (source: Jackman et al. Physiology (Bethesda). 2009 October ; 24: 290–297. doi:10.1152/physiol.00016.2009) Clemastine is a first generation anti-histamine used to relieve the signs and symptoms of hay fever. However, it is its purported remyelination properties have garnered great interest in the MS community. No fairy tale run smoothly as you can see from this recent...

The take on BTK inhibitors: AAN 2021 has the answers

The scientific sessions at AAN 2021 were pretty devoid of exciting new developments (not surprising given COVID19), but did present updates on the use of BTK (Bruton’s Tyrosine Kinase) inhibitors in multiple sclerosis (MS). For those of you who hearing this term for the first time today, BTK inhibitors target both B cells in the periphery and resident microglia in the brain (see slide...

Chronic lesion activity in MS as seen on MRI

If you’d asked an year ago on whether I though MRI had a role beyond diagnosis in MS? My answer would have been an emphatic ‘NO’. The Achilles heel of MRI has always been the difficulty of standardizing scanning techniques to a large scale population level and adapting these accurately to work seamlessly during the day-to-day shortcomings of clinical imaging facilities within...

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