Tagnatalizumab

#AttackMS

AttackMS was conceived on the 29th of Nov 2017 over a beer or two (or was it Elderflower?) at the Lago Maggiore. Prof Jeremy Hobart (Plymouth), ProfG and I sat down on the eve of the annual meeting of the European Charcot Foundation in Baveno, and I said something along the lines of: “Why don’t we treat MS with highly effective disease modifying treatment (HE-DMT) at first...

Top Trumps, are you getting your money’s worth in treatment?

The latest real-world data analysis from the MS-Base consortium demonstrates that natalizumab as opposed to fingolimod or the platform therapies (injectables and starter oral treatments) is most cost-effective for MS. Although, natalizumab is more expensive than fingolimod ( £3765/individual higher) and has increased occurrence of PML in natalizumab vs. fingolimod that would have reduced the...

The age of innocence

Once upon a time there was a boy. He lived in a well-to-do neighborhood, had everything that he needed, his parents loved him and everything was possible. One day whilst playing football his leg gave way and he could no longer walk like his mates. This was the start of his journey into MS and adulthood. Age matters in MS. Pediatric MS typically refers to the development of MS before 18 years of...

Let’s get ready to rumble!

If the heavy weights of MS drugs go head to head in the boxing ring, it is anyone’s guess who will come out on top. The MS Base publication in 2019 states that starting on fingolimod, alemtuzumab or natalizumab is superior to glatiramer acetate or interferon beta. This March, the Italians have sneakily put together their own contest between fingolimod and natalizumab. You may say this one...

MS DMTs that hit the regenerative note

Santiago Ramon y Cajal Who said that the brain doesn’t regenerate? Well, it was the neuroscience Dogma as far back as philosophy. But, not in certain quarters; Santiago Ramon y Cajal (1852-1934), widely believed to be the father of modern neuroscience in his treatise ‘Degeneration and Regeneration of the Nervous System’, alludes to the potential of the brain to regenerate in the...

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