Tagpaediatric MS

Teriflunomide fails in Paediatric MS for primary outcome

Teriflunomide (Aubagio) holds a license for adult RRMS with an efficacy of roughly 30% relapse rate reduction versus placebo (dummy tablet). The long awaited study in paediatric MS (TERIKIDS study) recently published, however has failed to meet its primary endpoint – time to first confirmed clinical relapse in the teriflunomide group vs. placebo. The probability of first confirmed relapse...

The age of innocence

Once upon a time there was a boy. He lived in a well-to-do neighborhood, had everything that he needed, his parents loved him and everything was possible. One day whilst playing football his leg gave way and he could no longer walk like his mates. This was the start of his journey into MS and adulthood. Age matters in MS. Pediatric MS typically refers to the development of MS before 18 years of...

Ageing brain – lessons from childhood MS

Childhood onset MS has some unique features compared to adult onset MS. Firstly, it tends to be more active than adult onset MS with a greater number of relapses and more MRI activity, but equally has better reparative capacity and a later onset of progressive disease. But this is as far as the dis-similarities go. If it walks like a duck and quacks like a duck, I call that bird a duck! In a two...

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