TagT cells

Dimethyl fumarate for Primary Progressive MS? Is it all just MS

Figure of DMF action from Frontiers in Neurology A fair number of you probably take Dimethyl Fumarate (DMF) for your relapsing remitting MS, but did you realise that it may also work in Primary Progressive MS? This is what this latest piece of research suggests. There is one basic principle to MS treatments as a whole; which is that the treatment efficacy is very much in line with the extent of...

T cells bite the dust

An interesting presentation from this years MSVirtual2020 was presentation by Dr Beatrice Wasser on ‘GlcNac signalling to reduce T cell pathogenicity in MS’. Abstract Background: Both adaptive and innate immune cells infiltrate the CNS during multiple sclerosis (MS) and in its animal model experimental autoimmune encephalomyelitis (EAE). Pathogenic T cells are known as key drivers of...

Memory B cells are there to help CD4 T cells

Memory B Cells present antigen to CD4 T cells in multiple sclerosis, so T cells are on top of the pile and B cells are there to help the baddie T cells. Therefore, the status quo is maintained and everything is super. However, has the latest autoantigen in MS been found? Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis. Jelcic I , Al Nimer F , Wang J ...



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