Tagvaccines

#MSCOVID19: antibody testing post-vaccine

Barts-MS rose-tinted-odometer: ★★★ Should I get an antibody test to prove that I have responded to the COVID-19 vaccine? No, you shouldn’t. Most diagnostic COVID-19/SARS-CoV-2 antibody tests are based on detecting antibodies to the so-called nucleocapsid protein and not the spike protein, which is the protein or immunogen used in the current vaccines. There are, however, a few private...

#MSCOVID19: triMSx-online

You may remember that about 6 years ago the idea was germinated on this blog to launch an online version of ECTRIMS to reach people in low- and middle-income countries and to allow more women with family commitments to attend meetings. The other aim was to usher in the next generation of young MSologists; more women, younger people, more ethnic diversity and from all regions of over the world, i...

Why does fingolimod affect antibody responses?

Barts-MS rose-tinted-odometer:  ★ The Twittersphere is abuzz with the preliminary seroconversion rates in Israelis patients with MS on various DMTs in response to the Pfizer-BionTech COVID-19 vaccine (see below). As expected the antibody seroconversion rates in response to anti-CD20 therapies and S1P modulators are blunted and in most cases inhibited. The backstory or biology around anti...

#MSCOVID19: cladribine is being unfairly tarnished with alemtuzumab’s brush

Barts-MS rose-tinted-odometer: ★★★★★ I think the North American MS community have made some mistakes with their COVID-19 vaccine recommendations, in particular, the NMSS COVID-19 vaccine guidelines for cladribine. In view of the immunology of cladribine’s mode of action and new data that is emerging, I would suggest the NMSS considers updating its guidelines.  Lemtrada and MavencladIf...

#MSCOVID19: Vaccine Q&A page is now live

Barts-MS rose-tinted-odometer: ★★★★★ Just to let you know that the I have answered all the reasonable questions that have come in via the COVID-19 decision aid. To keep it simple and to allow me to be more responsive I will simply update the online document every day or so. This is similar to what I did with the MS-Selfie Microsite I ran for at the beginning of the pandemic. Loading… Loading…...

#MSCOVID19: Vaccine Decision Aid ver. 2.0

Barts-MS rose-tinted-odometer: ★★★★★ Thank you for the feedback on my rough-and-ready decision aid. It is clear there is a need for it. I have spent a bit of time adding DMT-specific pages to the aid and added sections on ‘Which vaccine?’ and ‘Pregnancy’. I have also added a page with useful links. I have also set the sound to be on-demand rather than being automatic; so...

#MSCOVID19: What is vaccination?

Barts-MS rose-tinted-odometer: ★★★★★ What is vaccination? A not so simple medical procedure. Vaccination is probably one of, if not, the most important scientific/medical inventions in modern history. We need to celebrate it for just that and appreciate the number of saved lives and improved quality of life it has brought to us as a species.  Now that we broadly know how the immune system...

#MSCOVID19: from the horse’s mouth

Barts-MS rose-tinted-odometer: ★★★★★ The horse’s mouth = the MHRA (Medicines and Healthcare products Regulatory Agency) I have received several vexatious emails accusing me of subjecting my patients, and people with MS (pwMS) in general, to an experiment by recommending and promoting the COVID-19 vaccines. I want to remind the readers that we need to listen to experts. I was challenged that...

To be vaccinated or not?

The following is a preliminary summary of the UK MS Register’s survey to establish how people with MS (pwMS) viewed the arrival of the COVID-19 vaccinations. Importantly, the data shows that despite being quite vocal the anti-vaccine message doesn’t seem to be having the same effect in the UK as it is in other countries. Fewer than 6% of respondents said they would probably or...

#MSCOVID19: yes, have the vaccine

Barts-MS rose-tinted-odometer: ★★★★★ Despite the long blog post that I called CATCH-22 I am still getting numerous emails and questions from patients with MS about whether or not they should have a COVID-19 vaccine. YES, you should have the vaccine when it is offered to you. Clearly, timely access to the vaccine will depend on where you live, how vulnerable you are and the local, regional and...

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